Search Results - "Manoutcharian, Karen"

Recombinant Antibody Fragments for Neurodegenerative Diseases by Manoutcharian, Karen, Perez-Garmendia, Roxanna, Gevorkian, Goar

“…Background: Recombinant antibody fragments are promising alternatives to full-length immunoglobulins and offer important advantages compared with conventional…”
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Amyloid-β peptide binds to cytochrome C oxidase subunit 1 by Hernandez-Zimbron, Luis Fernando, Luna-Muñoz, Jose, Mena, Raul, Vazquez-Ramirez, Ricardo, Kubli-Garfias, Carlos, Cribbs, David H, Manoutcharian, Karen, Gevorkian, Goar

“…Extracellular and intraneuronal accumulation of amyloid-beta aggregates has been demonstrated to be involved in the pathogenesis of Alzheimer's disease (AD)…”
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Are we getting closer to a successful neoantigen cancer vaccine? by Manoutcharian, Karen, Gevorkian, Goar

“…Although significant advances in immunotherapy have revolutionized the treatment of many cancer types over the past decade, the field of vaccine therapy, an…”
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Shark VNAR phage display libraries: An alternative source for therapeutic and diagnostic recombinant antibody fragments by Manoutcharian, Karen, Gevorkian, Goar

“…The development of recombinant antibody fragments as promising alternatives to full-length immunoglobulins offers vast opportunities for biomedicine. Antibody…”
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Data concerning secondary structure and alpha-glucans-binding capacity of the LaCBM26 by Armenta, Silvia, Sánchez-Cuapio, Zaira, Farrés, Amelia, Manoutcharian, Karen, Hernandez-Santoyo, Alejandra, Sánchez, Sergio, Rodríguez-Sanoja, Romina

“…Carbohydrate-binding modules (CBMs) are auxiliary domains into glycoside-hydrolases that allow the interaction between the insoluble substrate and the…”
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Recombinant Antibody Fragments for Immunotherapy of Parkinson’s Disease by Manoutcharian, Karen, Gevorkian, Goar

“…Parkinson’s disease (PD) is the second most common age-related neurodegenerative disorder. Multiple genetic and environmental factors leading to progressive…”
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Towards a Taenia solium Cysticercosis Vaccine: an Epitope Shared by Taenia crassiceps and Taenia solium Protects Mice against Experimental Cysticercosis by TOLEDO, A, LARRALDE, C, VAZQUEZ, R, TERRAZAS, I, SCIUTTO, E, FRAGOSO, G, GEVORKIAN, G, MANOUTCHARIAN, K, HERNANDEZ, M, ACERO, G, ROSAS, G, LOPEZ-CASILLAS, F, KUBLI GARFIAS, C

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Neoantigen Cancer Vaccines: Real Opportunity or Another Illusion? by Manoutcharian, Karen, Guzman Valle, Jesus, Gevorkian, Goar

“…In this communication, we will analyze some important factors and immunological phenomena related to neoantigen cancer vaccines, with particular emphasis on…”
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Phage-Displayed T-Cell Epitope Grafted into Immunoglobulin Heavy-Chain Complementarity-Determining Regions: an Effective Vaccine Design Tested in Murine Cysticercosis by MANOUTCHARIAN, K, TERRAZAS, L. I, GEVORKIAN, G, ACERO, G, PETROSSIAN, P, RODRIGUEZ, M, GOVEZENSKY, T

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Immunogenic properties of immunoglobulin superfamily members within complex biological networks by Odales, Josué, Guzman Valle, Jesus, Martínez-Cortés, Fernando, Manoutcharian, Karen

“…•Antibody-based therapies induce CDR-specific T and B cell responses.•Idiotype-anti-idiotype network alters immune system memory compartment.•Antigenized…”
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Antitumor efficacy of MUC1-derived variable epitope library treatments in a mouse model of breast cancer by Odales, Josué, Servín-Blanco, Rodolfo, Martínez-Cortés, Fernando, Guzman Valle, Jesus, Domínguez-Romero, Allan Noé, Gevorkian, Goar, Manoutcharian, Karen

“…•MUC1 signal peptide-derived Variable Epitope Libraries show antitumor effects.•Vaccination induces a pool of CD8+ T cells which recognize most variant…”
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Genomic instability, origin and evolution of cancer, and personalized immunotherapy by Maruri, Jorge, Martínez-Cortés, Fernando, Odales, Josué, Manoutcharian, Karen

“…Cancer is a set of related diseases of genetic origin characterised by a high genetic and/or antigenic variability. Identification of tumour-specific antigens…”
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Generation of cancer vaccine immunogens derived from Oncofetal antigen (OFA/iLRP) using variable epitope libraries tested in an aggressive breast cancer model by Martínez-Cortés, Fernando, Servín-Blanco, Rodolfo, Domínguez-Romero, Allan Noé, Munguía, María Elena, Guzman Valle, Jesus, Odales, Josué, Gevorkian, Goar, Manoutcharian, Karen

“…•Variable Epitope Library (VEL) carries a large number of epitope variants.•The VELs derived from oncofetal OFA/iLRP inhibited tumor growth and metastasis.•The…”
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Tumor antigen-unbiased variable epitope library contains mimotopes with antitumor effect in a mouse model of breast cancer by Martínez-Cortés, Fernando, Domínguez-Romero, Allan Noé, Pérez-Hernández, Eréndira G., Orozco-Delgado, Diana L., Avila, Sandra, Odales, Josué, Guzman Valle, Jesus, Gevorkian, Goar, Manoutcharian, Karen

“…Breast cancer is one of the leading causes of death that affects the female population worldwide. Despite advances in treatments and a greater understanding of…”
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Protection against murine cysticercosis using cDNA expression library immunization by Manoutcharian, Karen, Terrazas, Luis Ignacio, Gevorkian, Goar, Govezensky, Tzipe

“…Genetic or DNA-based immunization, including genomic immunization, has shown to be a viable alternative approach to induce protective immunity against a number…”
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Generation of multiepitope cancer vaccines based on large combinatorial libraries of survivin‐derived mutant epitopes by Domínguez‐Romero, Allan Noé, Martínez‐Cortés, Fernando, Munguía, María Elena, Odales, Josué, Gevorkian, Goar, Manoutcharian, Karen

“…We developed a novel vaccine approach based on a new class of vaccine immunogens, called variable epitope libraries (VELs). We showed significant tumor growth…”
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Generation of cancer vaccine immunogens derived from major histocompatibility complex (MHC) class I molecules using variable epitope libraries by Servín-Blanco, Rodolfo, Chávaro-Ortiz, Rosa Mariana, Zamora-Alvarado, Rubén, Martínez-Cortes, Fernando, Gevorkian, Goar, Manoutcharian, Karen

“…•Broad T-cell spectrum is necessary to overcome antigenic heterogeneity in tumors.•MHC class I molecule-derived T-cell epitope libraries inhibit 4T1 tumor…”
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The role of conserved non-aromatic residues in the Lactobacillus amylovorus α-amylase CBM26-starch interaction by Armenta, Silvia, Sánchez-Cuapio, Zaira, Munguia, Maria Elena, Pulido, Nancy O., Farrés, Amelia, Manoutcharian, Karen, Hernandez-Santoyo, Alejandra, Moreno-Mendieta, Silvia, Sánchez, Sergio, Rodríguez-Sanoja, Romina

“…It is generally accepted that carbohydrate binding modules (CBMs) recognize their carbohydrate ligands by hydrophobic and CH-π interactions. Point mutations of…”
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Variable epitope libraries: New vaccine immunogens capable of inducing broad human immunodeficiency virus type 1-neutralizing antibody response by Charles-Niño, Claudia, Pedroza-Roldan, Cesar, Viveros, Monica, Gevorkian, Goar, Manoutcharian, Karen

“…Abstract The extreme antigenic variability of human immunodeficiency virus (HIV) leads to immune escape of the virus, representing a major challenge in the…”
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Inestabilidad genética, origen y evolución del cáncer y la inmunoterapia personalizada by Maruri, Jorge, Martínez-Cortés, Fernando, Odales, Josué, Manoutcharian, Karen

“…El cáncer es un conjunto de enfermedades relacionadas de origen genético que se caracterizan por una alta variabilidad genética y/o antigénica. La…”
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