Search Results - "Manoury, Boris"

TMEM16A/Anoctamin 1 protein mediates calcium‐activated chloride currents in pulmonary arterial smooth muscle cells by Manoury, Boris, Tamuleviciute, Aiste, Tammaro, Paolo

“…Calcium‐activated chloride channels (CaCCs) play important roles in several physiological processes. In vascular smooth muscle, activation of these ion…”
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Nicotinamide Riboside Preserves Cardiac Function in a Mouse Model of Dilated Cardiomyopathy by Diguet, Nicolas, Trammell, Samuel A.J, Tannous, Cynthia, Deloux, Robin, Piquereau, Jérôme, Mougenot, Nathalie, Gouge, Anne, Gressette, Mélanie, Manoury, Boris, Blanc, Jocelyne, Breton, Marie, Decaux, Jean-François, Lavery, Gareth G, Baczkó, István, Zoll, Joffrey, Garnier, Anne, Li, Zhenlin, Brenner, Charles, Mericskay, Mathias

“…BACKGROUND:Myocardial metabolic impairment is a major feature in chronic heart failure. As the major coenzyme in fuel oxidation and oxidative phosphorylation…”
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Potassium Channel Subfamily K Member 3 (KCNK3) Contributes to the Development of Pulmonary Arterial Hypertension by Antigny, Fabrice, Hautefort, Aurélie, Meloche, Jolyane, Belacel-Ouari, Milia, Manoury, Boris, Rucker-Martin, Catherine, Péchoux, Christine, Potus, François, Nadeau, Valérie, Tremblay, Eve, Ruffenach, Grégoire, Bourgeois, Alice, Dorfmüller, Peter, Breuils-Bonnet, Sandra, Fadel, Elie, Ranchoux, Benoît, Jourdon, Philippe, Girerd, Barbara, Montani, David, Provencher, Steeve, Bonnet, Sébastien, Simonneau, Gérald, Humbert, Marc, Perros, Frédéric

“…BACKGROUND—Mutations in the KCNK3 gene have been identified in some patients suffering from heritable pulmonary arterial hypertension (PAH). KCNK3 encodes an…”
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Two-pore potassium channels in the cardiovascular system by Gurney, Alison, Manoury, Boris

“…Two-pore domain (K 2P ) channels emerged about a decade ago and since then have been an expanding area of interest. This is because their biophysical and…”
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Enhanced Expression of β3-Adrenoceptors in Cardiac Myocytes Attenuates Neurohormone-Induced Hypertrophic Remodeling Through Nitric Oxide Synthase by Belge, Catharina, Hammond, Joanna, Dubois-Deruy, Emilie, Manoury, Boris, Hamelet, Julien, Beauloye, Christophe, Markl, Andreas, Pouleur, Anne-Catherine, Bertrand, Luc, Esfahani, Hrag, Jnaoui, Karima, Götz, Konrad R, Nikolaev, Viacheslav O, Vanderper, Annelies, Herijgers, Paul, Lobysheva, Irina, Iaccarino, Guido, Hilfiker-Kleiner, Denise, Tavernier, Geneviève, Langin, Dominique, Dessy, Chantal, Balligand, Jean-Luc

“…BACKGROUND—β1-2-adrenergic receptors (AR) are key regulators of cardiac contractility and remodeling in response to catecholamines. β3-AR expression is…”
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The absence of reactive oxygen species production protects mice against bleomycin-induced pulmonary fibrosis by Manoury, Boris, Nenan, Soazig, Leclerc, Olivier, Guenon, Isabelle, Boichot, Elisabeth, Planquois, Jean-Michel, Bertrand, Claude P, Lagente, Vincent

“…Reactive oxygen species and tissue remodeling regulators, such as metalloproteinases (MMPs) and their inhibitors (TIMPs), are thought to be involved in the…”
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Beta-3 Adrenoceptors as New Therapeutic Targets for Cardiovascular Pathologies by Gauthier, Chantal, Rozec, Bertrand, Manoury, Boris, Balligand, Jean-Luc

“…Catecholamines play a key role in the regulation of cardiovascular function, classically through ß 1/2 -adrenoreceptors (AR) activation. After ß 3 -AR cloning…”
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Influence of early neutrophil depletion on MMPs/TIMP-1 balance in bleomycin-induced lung fibrosis by Manoury, Boris, Nénan, Soizig, Guénon, Isabelle, Lagente, Vincent, Boichot, Elisabeth

“…Pulmonary fibrosis is characterized by excessive deposition of extracellular matrix in interstitium resulting in respiratory failure associated with…”
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Ion channels as effectors of cyclic nucleotide pathways: Functional relevance for arterial tone regulation by Manoury, Boris, Idres, Sarah, Leblais, Véronique, Fischmeister, Rodolphe

“…Numerous mediators and drugs regulate blood flow or arterial pressure by acting on vascular tone, involving cyclic nucleotide intracellular pathways. These…”
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Macrophage metalloelastase (MMP-12) deficiency does not alter bleomycin-induced pulmonary fibrosis in mice by Manoury, Boris, Nenan, Soazig, Guenon, Isabelle, Boichot, Elisabeth, Planquois, Jean-Michel, Bertrand, Claude P, Lagente, Vincent

“…Pulmonary fibrosis is characterized by excessive deposition of extracellular matrix in the interstitium resulting in respiratory failure. The role of…”
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Cyclic nucleotide signalling compartmentation by PDEs in cultured vascular smooth muscle cells by Zhang, Liang, Bouadjel, Kaouter, Manoury, Boris, Vandecasteele, Grégoire, Fischmeister, Rodolphe, Leblais, Véronique

“…Background and Purpose Up‐regulation of phosphodiesterases (PDEs) is associated with several vascular diseases, and better understanding of the roles of each…”
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Role of the PKA Type I in aorta by Wang, Liting, Dessillons, Matthieu, Pidoux, Guillaume, Fischmeister, Rodolphe, Vandecasteele, Grégoire, Leblais, Véronique, Manoury, Boris

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Characterization of Kcnk3-Mutated Rat, a Novel Model of Pulmonary Hypertension by Lambert, Mélanie, Capuano, Véronique, Boet, Angèle, Tesson, Laurent, Bertero, Thomas, Nakhleh, Morad K, Remy, Séverine, Anegon, Ignacio, Pechoux, Christine, Hautefort, Aurélie, Rucker-Martin, Catherine, Manoury, Boris, Domergue, Valérie, Mercier, Olaf, Girerd, Barbara, Montani, David, Perros, Frédéric, Humbert, Marc, Antigny, Fabrice

“…RATIONALE:Pulmonary arterial hypertension is a severe lethal cardiopulmonary disease. Loss of function mutations in KCNK3 (potassium channel subfamily K member…”
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Bmpr2 Mutant Rats Develop Pulmonary and Cardiac Characteristics of Pulmonary Arterial Hypertension by Hautefort, Aurélie, Mendes-Ferreira, Pedro, Sabourin, Jessica, Manaud, Grégoire, Bertero, Thomas, Rucker-Martin, Catherine, Riou, Marianne, Adão, Rui, Manoury, Boris, Lambert, Mélanie, Boet, Angèle, Lecerf, Florence, Domergue, Valérie, Brás-Silva, Carmen, Gomez, Ana Maria, Montani, David, Girerd, Barbara, Humbert, Marc, Antigny, Fabrice, Perros, Frédéric

“…BACKGROUND:Monoallelic mutations in the gene encoding bone morphogenetic protein receptor 2 (Bmpr2) are the main genetic risk factor for heritable pulmonary…”
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Role of SERCA3 protein in alpha1-adrenoceptor-mediated calcium signaling in mouse aortic function by Toth, Maeliss, Manoury, Boris, Varin, Audrey, Vandecasteele, Grégoire, Bobe, Régis, Leblais, Véronique

“…Calcium homeostasis plays a major role in vascular tone. Sarco/endoplasmic reticulum Ca2+-ATPases (SERCAs) contribute to generate intracellular calcium stores…”
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Phosphodiesterases type 2, 3 and 4 promote vascular tone in mesenteric arteries from rats with heart failure by Wang, Liting, Hubert, Fabien, Idres, Sarah, Belacel-Ouari, Milia, Domergue, Valérie, Domenichini, Séverine, Lefebvre, Florence, Mika, Delphine, Fischmeister, Rodolphe, Leblais, Véronique, Manoury, Boris

“…Phosphodiesterases (PDE) type 3 and 4 promote vasoconstriction by hydrolysing cAMP. In experimental heart failure (HF), PDE3 makes PDE4 redundant in aorta, but…”
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Role of SERCA3-dependent calcium signaling in mouse aortic function by Toth, Maeliss, Manoury, Boris, Bobe, Régis, Leblais, Véronique

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Preliminary characterization of phosphodiesterase-9 in rodent and human pulmonary artery by Wang, Liting, Zhang, Liang, Bouadjel, Kaouter, Varin, Audrey, Perros, Frédéric, Antigny, Fabrice, Mercier, Olaf, Fischmeister, Rodolphe, Leblais, Véronique, Manoury, Boris

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Contribution of BKCa channels to vascular tone regulation by PDE3 and PDE4 is lost in heart failure by Idres, Sarah, Perrin, Germain, Domergue, Valérie, Lefebvre, Florence, Gomez, Susana, Varin, Audrey, Fischmeister, Rodolphe, Leblais, Véronique, Manoury, Boris

“…Abstract Aims Regulation of vascular tone by 3′,5′-cyclic adenosine monophosphate (cAMP) involves many effectors including the large conductance,…”
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TMEM16A is a Calcium-Activated Chloride Channel in Pulmonary Artery Smooth Muscle Cells by Paolo, Tammaro, Manoury, Boris

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