Search Results - "Manos, Michael"

Molecular Pathways of Colon Inflammation Induced by Cancer Immunotherapy by Luoma, Adrienne M., Suo, Shengbao, Williams, Hannah L., Sharova, Tatyana, Sullivan, Keri, Manos, Michael, Bowling, Peter, Hodi, F. Stephen, Rahma, Osama, Sullivan, Ryan J., Boland, Genevieve M., Nowak, Jonathan A., Dougan, Stephanie K., Dougan, Michael, Yuan, Guo-Cheng, Wucherpfennig, Kai W.

“…Checkpoint blockade with antibodies specific for the PD-1 and CTLA-4 inhibitory receptors can induce durable responses in a wide range of human cancers…”
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Therapeutically Increasing MHC-I Expression Potentiates Immune Checkpoint Blockade by Gu, Shengqing Stan, Zhang, Wubing, Wang, Xiaoqing, Jiang, Peng, Traugh, Nicole, Li, Ziyi, Meyer, Clifford, Stewig, Blair, Xie, Yingtian, Bu, Xia, Manos, Michael P, Font-Tello, Alba, Gjini, Evisa, Lako, Ana, Lim, Klothilda, Conway, Jake, Tewari, Alok K, Zeng, Zexian, Sahu, Avinash Das, Tokheim, Collin, Weirather, Jason L, Fu, Jingxin, Zhang, Yi, Kroger, Benjamin, Liang, Jin Hua, Cejas, Paloma, Freeman, Gordon J, Rodig, Scott, Long, Henry W, Gewurz, Benjamin E, Hodi, F Stephen, Brown, Myles, Liu, X Shirley

“…Immune checkpoint blockade (ICB) therapy revolutionized cancer treatment, but many patients with impaired MHC-I expression remain refractory. Here, we combined…”
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Soluble PD-L1 as a Biomarker in Malignant Melanoma Treated with Checkpoint Blockade by Zhou, Jun, Mahoney, Kathleen M, Giobbie-Hurder, Anita, Zhao, Fengmin, Lee, Sandra, Liao, Xiaoyun, Rodig, Scott, Li, Jingjing, Wu, Xinqi, Butterfield, Lisa H, Piesche, Matthias, Manos, Michael P, Eastman, Lauren M, Dranoff, Glenn, Freeman, Gordon J, Hodi, F Stephen

“…Blockade of the pathway including programmed death-ligand 1 (PD-L1) and its receptor programmed cell death protein 1 (PD-1) has produced clinical benefits in…”
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Antigen dominance hierarchies shape TCF1+ progenitor CD8 T cell phenotypes in tumors by Burger, Megan L., Cruz, Amanda M., Crossland, Grace E., Gaglia, Giorgio, Ritch, Cecily C., Blatt, Sarah E., Bhutkar, Arjun, Canner, David, Kienka, Tamina, Tavana, Sara Z., Barandiaran, Alexia L., Garmilla, Andrea, Schenkel, Jason M., Hillman, Michelle, de los Rios Kobara, Izumi, Li, Amy, Jaeger, Alex M., Hwang, William L., Westcott, Peter M.K., Manos, Michael P., Holovatska, Marta M., Hodi, F. Stephen, Regev, Aviv, Santagata, Sandro, Jacks, Tyler

“…CD8 T cell responses against different tumor neoantigens occur simultaneously, yet little is known about the interplay between responses and its impact on…”
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A new paradigm for adult ADHD: A focused strategy to monitor treatment by Manos, Michael J, Short, Elizabeth J

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Early Use of High-Dose Glucocorticoid for the Management of irAE Is Associated with Poorer Survival in Patients with Advanced Melanoma Treated with Anti-PD-1 Monotherapy by Bai, Xue, Hu, Jiani, Betof Warner, Allison, Quach, Henry T, Cann, Christopher G, Zhang, Michael Z, Si, Lu, Tang, Bixia, Cui, Chuanliang, Yang, Xiaoling, Wei, Xiaoting, Pallan, Lalit, Harvey, Catriona, Manos, Michael P, Ouyang, Olivia, Kim, Michelle S, Kasumova, Gyulnara, Cohen, Justine V, Lawrence, Donald P, Freedman, Christine, Fadden, Riley M, Rubin, Krista M, Sharova, Tatyana, Frederick, Dennie T, Flaherty, Keith T, Rahma, Osama E, Long, Georgina V, Menzies, Alexander M, Guo, Jun, Shoushtari, Alexander N, Johnson, Douglas B, Sullivan, Ryan J, Boland, Genevieve M

“…Programmed cell death receptor-1 (PD-1) inhibitors are frontline therapy in advanced melanoma. Severe immune-related adverse effects (irAEs) often require…”
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Immune-Related Tumor Response Dynamics in Melanoma Patients Treated with Pembrolizumab: Identifying Markers for Clinical Outcome and Treatment Decisions by Nishino, Mizuki, Giobbie-Hurder, Anita, Manos, Michael P, Bailey, Nancy, Buchbinder, Elizabeth I, Ott, Patrick A, Ramaiya, Nikhil H, Hodi, F Stephen

“…Characterize tumor burden dynamics during PD-1 inhibitor therapy and investigate the association with overall survival (OS) in advanced melanoma. The study…”
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In Reply: A new paradigm for adult ADHD by Manos, Michael J., Short, Elizabeth J.

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ADHD: Overdiagnosed and overtreated, or misdiagnosed and mistreated? by Manos, Michael J, Giuliano, Kimberly, Geyer, Eric

“…In today's changing medical climate, physicians need to treat attention-deficit/hyperactivity disorder (ADHD) better and more cost-effectively. The authors…”
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Inactivation of Fbxw7 Impairs dsRNA Sensing and Confers Resistance to PD-1 Blockade by Gstalder, Cécile, Liu, David, Miao, Diana, Lutterbach, Bart, DeVine, Alexander L, Lin, Chenyu, Shettigar, Megha, Pancholi, Priya, Buchbinder, Elizabeth I, Carter, Scott L, Manos, Michael P, Rojas-Rudilla, Vanesa, Brennick, Ryan, Gjini, Evisa, Chen, Pei-Hsuan, Lako, Ana, Rodig, Scott, Yoon, Charles H, Freeman, Gordon J, Barbie, David A, Hodi, F Stephen, Miles, Wayne, Van Allen, Eliezer M, Haq, Rizwan

“…The molecular mechanisms leading to resistance to PD-1 blockade are largely unknown. Here, we characterize tumor biopsies from a patient with melanoma who…”
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Angiopoietin-2 as a Biomarker and Target for Immune Checkpoint Therapy by Wu, Xinqi, Giobbie-Hurder, Anita, Liao, Xiaoyun, Connelly, Courtney, Connolly, Erin M, Li, Jingjing, Manos, Michael P, Lawrence, Donald, McDermott, David, Severgnini, Mariano, Zhou, Jun, Gjini, Evisa, Lako, Ana, Lipschitz, Mikel, Pak, Christine J, Abdelrahman, Sara, Rodig, Scott, Hodi, F Stephen

“…Immune checkpoint therapies targeting CTLA-4 and PD-1 have proven effective in cancer treatment. However, the identification of biomarkers for predicting…”
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Development of an Objective Autism Risk Index Using Remote Eye Tracking by Frazier, Thomas W., PhD, Klingemier, Eric W., BA, Beukemann, Mary, Speer, Leslie, PhD, NCSP, Markowitz, Leslie, PsyD, Parikh, Sumit, MD, Wexberg, Steven, MD, Giuliano, Kimberly, MD, Schulte, Elaine, MD, MPH, Delahunty, Carol, MD, Ahuja, Veena, MD, Eng, Charis, MD, PhD, Manos, Michael J., PhD, Hardan, Antonio Y., MD, Youngstrom, Eric A., PhD, Strauss, Mark S., PhD

“…Objective Abnormal eye gaze is a hallmark characteristic of autism spectrum disorder (ASD), and numerous studies have identified abnormal attention patterns in…”
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Distinct predictive biomarker candidates for response to anti-CTLA-4 and anti-PD-1 immunotherapy in melanoma patients by Subrahmanyam, Priyanka B, Dong, Zhiwan, Gusenleitner, Daniel, Giobbie-Hurder, Anita, Severgnini, Mariano, Zhou, Jun, Manos, Michael, Eastman, Lauren M, Maecker, Holden T, Hodi, F Stephen

“…While immune checkpoint blockade has greatly improved clinical outcomes in diseases such as melanoma, there remains a need for predictive biomarkers to…”
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Destabilization of NOXA mRNA as a common resistance mechanism to targeted therapies by Montero, Joan, Gstalder, Cécile, Kim, Daniel J., Sadowicz, Dorota, Miles, Wayne, Manos, Michael, Cidado, Justin R., Paul Secrist, J., Tron, Adriana E., Flaherty, Keith, Stephen Hodi, F., Yoon, Charles H., Letai, Anthony, Fisher, David E., Haq, Rizwan

“…Most targeted cancer therapies fail to achieve complete tumor regressions or attain durable remissions. To understand why these treatments fail to induce…”
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Pneumonitis resulting from radiation and immune checkpoint blockade illustrates characteristic clinical, radiologic and circulating biomarker features by Schoenfeld, Jonathan D, Nishino, Mizuki, Severgnini, Mariano, Manos, Michael, Mak, Raymond H, Hodi, F Stephen

“…Pneumonitis is a potential consequence of both lung-directed radiation and immune checkpoint blockade (ICB), particularly treatment with PD-1/PD-L1 inhibitors…”
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A deep molecular response of splenic marginal zone lymphoma to front-line checkpoint blockade by Miller, Peter G, Sperling, Adam S, Gibson, Christopher J, Pozdnyakova, Olga, Wong, Waihay J, Manos, Michael P, Buchbinder, Elizabeth I, Hodi, F Stephen, Ebert, Benjamin L, Davids, Matthew S

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EDIL3 as an Angiogenic Target of Immune Exclusion Following Checkpoint Blockade by Tabasum, Saba, Thapa, Dinesh, Giobbie-Hurder, Anita, Weirather, Jason L, Campisi, Marco, Schol, Pieter J, Li, Xiaoyu, Li, Jingjing, Yoon, Charles H, Manos, Michael P, Barbie, David A, Hodi, F Stephen

“…Immune checkpoint blockade (ICB) has become the standard of care for several solid tumors. Multiple combinatorial approaches have been studied to improve…”
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Elementary and Middle School Teachers’ Self-Reported Use of Positive Behavioral Supports for Children With ADHD: A National Survey by Hart, Katie C., Fabiano, Gregory A., Evans, Steven W., Manos, Michael J., Hannah, Jane N., Vujnovic, Rebecca K.

“…This study examined elementary and middle school teachers’ self-reported use of behavioral supports for students with attention-deficit/hyperactivity disorder…”
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Long-term Overall Survival and Predictors in Anti–PD-1-naive Melanoma Patients With Brain Metastases Treated With Immune Checkpoint Inhibitors in the Real-world Setting: A Multicohort Study by Naik, Girish S., Buchbinder, Elizabeth I., Cohen, Justine V., Manos, Michael P., Johnson, Alistair E.W., Bowling, Peter, Aizer, Ayal A., Schoenfeld, Jonathan D., Lawrence, Donald P., Haq, Rizwan, Hodi, Frank Stephen, Sullivan, Ryan J., Ott, Patrick A.

“…Long-term survival outcomes among melanoma patients with brain metastases treated with immune checkpoint inhibitors are limited. In this retrospective study at…”
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Immunity to X-linked inhibitor of apoptosis protein (XIAP) in malignant melanoma and check-point blockade by Zhou, Jun, Li, Jingjing, Guleria, Indira, Chen, Tianqi, Giobbie-Hurder, Anita, Stevens, Jonathan, Gupta, Meghna, Wu, Xinqi, Brennick, Ryan C., Manos, Michael P., Hodi, F. Stephen

“…Expression of inhibitors of apoptosis protein (IAP) family members is associated with poor prognosis in cancer patients. Immunity to ML-IAP (livin) and…”
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