Search Results - "Manoj K. Patel"

Genetically targeted magnetic control of the nervous system by Wheeler, Michael A, Smith, Cody J, Ottolini, Matteo, Barker, Bryan S, Purohit, Aarti M, Grippo, Ryan M, Gaykema, Ronald P, Spano, Anthony J, Beenhakker, Mark P, Kucenas, Sarah, Patel, Manoj K, Deppmann, Christopher D, Güler, Ali D

“…Elucidation of structure–function relationships in the nervous system necessitates biological circuit control with genetic and temporal precision. Here the…”
Get full text

Evidence for a role of Nav1.6 in facilitating increases in neuronal hyperexcitability during epileptogenesis by Hargus, Nicholas J, Nigam, Aradhya, Bertram, 3rd, Edward H, Patel, Manoj K

“…During epileptogenesis a series of molecular and cellular events occur, culminating in an increase in neuronal excitability, leading to seizure initiation. The…”
Get full text

Activation of murine pre-proglucagon-producing neurons reduces food intake and body weight by Gaykema, Ronald P, Newmyer, Brandon A, Ottolini, Matteo, Raje, Vidisha, Warthen, Daniel M, Lambeth, Philip S, Niccum, Maria, Yao, Ting, Huang, Yiru, Schulman, Ira G, Harris, Thurl E, Patel, Manoj K, Williams, Kevin W, Scott, Michael M

“…Peptides derived from pre-proglucagon (GCG peptides) act in both the periphery and the CNS to change food intake, glucose homeostasis, and metabolic rate while…”
Get full text

Carbon Dots Conjugated Antibody as an Effective FRET-Based Biosensor for Progesterone Hormone Screening by Disha, Kumari, Poonam, Patel, Manoj K, Kumar, Parveen, Nayak, Manoj K

“…In this work, carbon dots (CDs) were synthesized by a one-step hydrothermal method using citric acid and ethylene diamine, and covalently functionalized with…”
Get full text

EpiPro, a Novel, Synthetic, Activity-Regulated Promoter That Targets Hyperactive Neurons in Epilepsy for Gene Therapy Applications by Burke, Cassidy T, Vitko, Iuliia, Straub, Justyna, Nylund, Elsa O, Gawda, Agnieszka, Blair, Kathryn, Sullivan, Kyle A, Ergun, Lara, Ottolini, Matteo, Patel, Manoj K, Perez-Reyes, Edward

“…Epileptogenesis is characterized by intrinsic changes in neuronal firing, resulting in hyperactive neurons and the subsequent generation of seizure activity…”
Get full text

Peri-Ictal Autonomic Control of Cardiac Function and Seizure-Induced Death by Wenker, Ian C, Blizzard, Elizabeth A, Wagley, Pravin K, Patel, Manoj K

“…Sudden unexpected death in epilepsy (SUDEP) accounts for the deaths of 8-17% of patients with epilepsy. Although the mechanisms of SUDEP are unknown, one…”
Get full text

Adrenergic Mechanisms of Audiogenic Seizure-Induced Death in a Mouse Model of SCN8A Encephalopathy by Wengert, Eric R, Wenker, Ian C, Wagner, Elizabeth L, Wagley, Pravin K, Gaykema, Ronald P, Shin, Jung-Bum, Patel, Manoj K

“…Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death amongst patients whose seizures are not adequately controlled by current therapies…”
Get full text

Pro-excitatory alterations in sodium channel activity facilitate subiculum neuron hyperexcitability in temporal lobe epilepsy by Barker, Bryan S., Nigam, Aradhya, Ottolini, Matteo, Gaykema, Ronald P., Hargus, Nicholas J., Patel, Manoj K.

“…Temporal lobe epilepsy (TLE) is a common form of adult epilepsy involving the limbic structures of the temporal lobe. Subiculum neurons act to provide a major…”
Get full text

Forebrain epileptiform activity is not required for seizure-induced apnea in a mouse model of Scn8a epilepsy by Wenker, Ian C, Boscia, Alexis R, Lewis, Christine, Tariq, Anas, Miralles, Raquel, Hanflink, Jessica C, Saraf, Priyanka, Patel, Manoj K

“…Sudden unexpected death in epilepsy (SUDEP) accounts for the deaths of 8-17% of patients with epilepsy. Although the mechanisms of SUDEP are essentially…”
Get full text

Pathogenic mechanism of recurrent mutations of SCN8A in epileptic encephalopathy by Wagnon, Jacy L., Barker, Bryan S., Hounshell, James A., Haaxma, Charlotte A., Shealy, Amy, Moss, Timothy, Parikh, Sumit, Messer, Ricka D., Patel, Manoj K., Meisler, Miriam H.

“…Objective The early infantile epileptic encephalopathy type 13 (EIEE13, OMIM #614558) results from de novo missense mutations of SCN8A encoding the…”
Get full text

Activation of Pyramidal Neurons in Mouse Medial Prefrontal Cortex Enhances Food-Seeking Behavior While Reducing Impulsivity in the Absence of an Effect on Food Intake by Warthen, Daniel M, Lambeth, Philip S, Ottolini, Matteo, Shi, Yingtang, Barker, Bryan Scot, Gaykema, Ronald P, Newmyer, Brandon A, Joy-Gaba, Jonathan, Ohmura, Yu, Perez-Reyes, Edward, Güler, Ali D, Patel, Manoj K, Scott, Michael M

“…The medial prefrontal cortex (mPFC) is involved in a wide range of executive cognitive functions, including reward evaluation, decision-making, memory…”
Get full text

Temporal lobe epilepsy induces intrinsic alterations in Na channel gating in layer II medial entorhinal cortex neurons by Hargus, Nicholas J, Merrick, Ellen C, Nigam, Aradhya, Kalmar, Christopher L, Baheti, Aparna R, Bertram, Edward H, Patel, Manoj K

“…Abstract Temporal lobe epilepsy (TLE) is the most common form of adult epilepsy involving the limbic structures of the temporal lobe. Layer II neurons of the…”
Get full text

Astrocyte reactivity in a mouse model of SCN8A epileptic encephalopathy by Thompson, Jeremy A., Miralles, Raquel M., Wengert, Eric R., Wagley, Pravin K., Yu, Wenxi, Wenker, Ian C., Patel, Manoj K.

“…Objective SCN8A epileptic encephalopathy is caused predominantly by de novo gain‐of‐function mutations in the voltage‐gated sodium channel Nav1.6. The disorder…”
Get full text

Study of photospheric, chromospheric and coronal activities of V1147 Tau by Patel, Manoj K., Pandey, J. C., Savanov, Igor S., Prasad, Vinod, Srivastava, D. C.

“…We present analyses of optical photometric, spectroscopic, polarimetric and X-ray observations of the K5V binary star, V1147 Tau. Nearly 20 yr of optical…”
Get full text

Endothelial cell Pannexin1 modulates severity of ischemic stroke by regulating cerebral inflammation and myogenic tone by Good, Miranda E, Eucker, Stephanie A, Li, Jun, Bacon, Hannah M, Lang, Susan M, Butcher, Joshua T, Johnson, Tyler J, Gaykema, Ronald P, Patel, Manoj K, Zuo, Zhiyi, Isakson, Brant E

“…Ischemic stroke is a leading cause of morbidity and mortality in the US; however, there currently exists only one effective acute pharmacological therapeutic…”
Get full text

Current findings and future prospective of high-value trans Himalayan medicinal plant Lycium ruthenicum Murr: a systematic review by Sharma, Rajni, Raghuvanshi, Rinky, Kumar, Raj, Thakur, Mohan Singh, Kumar, Santosh, Patel, Manoj K., Chaurasia, O. P., Saxena, Shweta

“…Background The genus Lycium is commercially known for its nutrient dense goji-berries, among these berries, black goji-berries obtained from Lycium ruthenicum…”
Get full text

Emergence of selectivity and specificity in a coarse-grained model of the nuclear pore complex with sequence-agnostic FG-Nups by Patel, Manoj K, Chakrabarti, Buddhapriya, Panwar, Ajay S

“…The role of hydrophobicity of phenylalanine-glycine nucleoporins (FG-Nups) in determining the transport of receptor-bound cargo across the nuclear pore complex…”
Get more information

Validation of traditional claims of anti-arthritic efficacy of trans-Himalayan snow mountain garlic (Allium ampeloprasum L.) extract using adjuvant-induced arthritis rat model: A comparative evaluation with normal garlic (Allium sativum L.) and dexamethasone by Kaur, Bhupinder, Kumar, Nitish, Patel, Manoj K., Chopra, Kanwaljit, Saxena, Shweta

“…Snow Mountain Garlic (SMG) (Allium ampeloprasum L.) is a wild trans-Himalayan member of the genus Allium, valued for its anti-inflammatory and anti-arthritic…”
Get full text

Sol-Gel Derived Nanostructured Metal Oxide Platform for Bacterial Detection by Solanki, Pratima R., Patel, Manoj K., Kaushik, Ajeet, Pandey, M. K., Kotnala, R. K., Malhotra, B. D.

“…O1 gene based 24‐mer single stranded deoxyribonucleic acid probe (ssDNA) has been immobilized onto sol‐gel derived nanostructured zirconium oxide (NanoZrO2)…”
Get full text

Synthesis and evaluation of hermitamides A and B as human voltage-gated sodium channel blockers by De Oliveira, Eliseu O., Graf, Kristin M., Patel, Manoj K., Baheti, Aparna, Kong, Hye-Sik, MacArthur, Linda H., Dakshanamurthy, Sivanesan, Wang, Kan, Brown, Milton L., Paige, Mikell

“…Hermitamides A and B are lipopeptides isolated from a Papau New Guinea collection of the marine cyanobacterium Lyngbya majuscula. We hypothesized that the…”
Get full text