Search Results - "Manohar, Sanjay"

Motivation in Parkinson's disease: apathetic before you know it by Manohar, Sanjay G

“…This scientific commentary refers to ‘Putaminal dopamine modulates movement motivation in Parkinson’s disease’ by Banwinkler et al…”
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Tremor in Parkinson's disease inverts the effect of dopamine on reinforcement by Manohar, Sanjay G

“…This scientific commentary refers to ‘Effects of dopamine on reinforcement learning in Parkinson’s disease depend on motor phenotype’ by van Nuland et al…”
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Dopamine encoding of novelty facilitates efficient uncertainty-driven exploration by Wang, Yuhao, Lak, Armin, Manohar, Sanjay G, Bogacz, Rafal

“…When facing an unfamiliar environment, animals need to explore to gain new knowledge about which actions provide reward, but also put the newly acquired…”
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Reward Pays the Cost of Noise Reduction in Motor and Cognitive Control by Manohar, Sanjay G., Chong, Trevor T.-J., Apps, Matthew A.J., Batla, Amit, Stamelou, Maria, Jarman, Paul R., Bhatia, Kailash P., Husain, Masud

“…Speed-accuracy trade-off is an intensively studied law governing almost all behavioral tasks across species. Here we show that motivation by reward breaks this…”
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Neural mechanisms of attending to items in working memory by Manohar, Sanjay G., Zokaei, Nahid, Fallon, Sean J., Vogels, Tim P., Husain, Masud

“…•Evidence suggests both sustained activity and synaptic plasticity support working memory.•Rapid Hebbian plasticity can support flexible attractor states…”
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Cerebrovascular risk factors impact frontoparietal network integrity and executive function in healthy ageing by Veldsman, Michele, Tai, Xin-You, Nichols, Thomas, Smith, Steve, Peixoto, João, Manohar, Sanjay, Husain, Masud

“…Healthy cognitive ageing is a societal and public health priority. Cerebrovascular risk factors increase the likelihood of dementia in older people but their…”
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Rapid Forgetting Results From Competition Over Time Between Items in Visual Working Memory by Pertzov, Yoni, Manohar, Sanjay, Husain, Masud

“…Working memory is now established as a fundamental cognitive process across a range of species. Loss of information held in working memory has the potential to…”
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Uncertainty-guided learning with scaled prediction errors in the basal ganglia by Möller, Moritz, Manohar, Sanjay, Bogacz, Rafal

“…To accurately predict rewards associated with states or actions, the variability of observations has to be taken into account. In particular, when the…”
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Modulation of the pupillary response by the content of visual working memory by Zokaei, Nahid, Board, Alexander G., Manohar, Sanjay G., Nobre, Anna C.

“…Studies of selective attention during perception have revealed modulation of the pupillary response according to the brightness of task-relevant (attended) vs…”
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Reward-Based Improvements in Motor Control Are Driven by Multiple Error-Reducing Mechanisms by Codol, Olivier, Holland, Peter J, Manohar, Sanjay G, Galea, Joseph M

“…Reward has a remarkable ability to invigorate motor behavior, enabling individuals to select and execute actions with greater precision and speed. However, if…”
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Distinct Motivational Effects of Contingent and Noncontingent Rewards by Manohar, Sanjay G., Finzi, Rebecca Dawn, Drew, Daniel, Husain, Masud

“…When rewards are available, people expend more energy, increasing their motivational vigor. In theory, incentives might drive behavior for two distinct…”
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The psychopathology of NMDAR-antibody encephalitis in adults: a systematic review and phenotypic analysis of individual patient data by Al-Diwani, Adam, Handel, Adam, Townsend, Leigh, Pollak, Thomas, Leite, M Isabel, Harrison, Paul J, Lennox, Belinda R, Okai, David, Manohar, Sanjay G, Irani, Sarosh R

“…Early immunotherapy administration improves outcomes in patients with N-methyl-D-aspartate receptor (NMDAR)-antibody encephalitis. As most patients with…”
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Neural signature of flexible coding in prefrontal cortex by Bocincova, Andrea, Buschman, Timothy J, Stokes, Mark G, Manohar, Sanjay G

“…The ability of prefrontal cortex to quickly encode novel associations is crucial for adaptive behavior and central to working memory. Fast Hebbian changes in…”
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Motivation improves working memory by two processes: Prioritisation and retrieval thresholds by Grogan, John P., Randhawa, Govind, Kim, Minho, Manohar, Sanjay G.

“…•People can improve working memory accuracy for multiple stimuli when motivated by equal rewards.•Does not affect encoding or maintenance, but slows reaction…”
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The relationship between apathy and impulsivity in large population samples by Petitet, Pierre, Scholl, Jacqueline, Attaallah, Bahaaeddin, Drew, Daniel, Manohar, Sanjay, Husain, Masud

“…Apathy and impulsivity are debilitating conditions associated with many neuropsychiatric conditions, and expressed to variable degrees in healthy people. While…”
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Neural and computational mechanisms of momentary fatigue and persistence in effort-based choice by Müller, Tanja, Klein-Flügge, Miriam C., Manohar, Sanjay G., Husain, Masud, Apps, Matthew A. J.

“…From a gym workout, to deciding whether to persevere at work, many activities require us to persist in deciding that rewards are ‘worth the effort’ even as we…”
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Hippocampal volume across age: Nomograms derived from over 19,700 people in UK Biobank by Nobis, Lisa, Manohar, Sanjay G, Smith, Stephen M, Alfaro-Almagro, Fidel, Jenkinson, Mark, Mackay, Clare E, Husain, Masud

“…Measurement of hippocampal volume has proven useful to diagnose and track progression in several brain disorders, most notably in Alzheimer's disease (AD). For…”
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Motivation dynamically increases noise resistance by internal feedback during movement by Manohar, Sanjay G., Muhammed, Kinan, Fallon, Sean J., Husain, Masud

“…Motivation improves performance, pushing us beyond our normal limits. One general explanation for this is that the effects of neural noise can be reduced, at a…”
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Dissociable behavioural signatures of co-existing impulsivity and apathy in decision-making by Petitet, Pierre, Zhao, Sijia, Drew, Daniel, Manohar, Sanjay G., Husain, Masud

“…Apathy and impulsivity are expressed in a wide range of neuropsychiatric disorders, and, to a less severe extent, in healthy people too. Although traditionally…”
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Working memory as a representational template for reinforcement learning by Shibata, Kengo, Klar, Verena, Fallon, Sean J., Husain, Masud, Manohar, Sanjay G.

“…Working memory (WM) and reinforcement learning (RL) both influence decision-making, but how they interact to affect behaviour remains unclear. We assessed…”
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