Search Results - "Manoel O. MORAES"

Overview of the therapeutic potential of piplartine (piperlongumine) by Bezerra, Daniel P., Pessoa, Claudia, de Moraes, Manoel O., Saker-Neto, Nicolau, Silveira, Edilberto R., Costa-Lotufo, Leticia V.

“…Piplartine (piperlongumine, 5,6-dihydro-1-[(2E)-1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl]-2(1H)-pyridinone) is a biologically active alkaloid/amide from…”
Get full text

Preoperative Pulmonary Rehabilitation Versus Chest Physical Therapy in Patients Undergoing Lung Cancer Resection: A Pilot Randomized Controlled Trial by Morano, Maria T., PhD, Araújo, Amanda S., PT, Nascimento, Francisco B., PT, da Silva, Guilherme F., PT, Mesquita, Rafael, PT, Pinto, Juliana S., MSc, de Moraes Filho, Manoel O., PhD, Pereira, Eanes D., PhD

“…Abstract Objective To evaluate the effect of 4 weeks of pulmonary rehabilitation (PR) versus chest physical therapy (CPT) on the preoperative functional…”
Get full text

Antitumour properties of the leaf essential oil of Xylopia frutescens Aubl. (Annonaceae) by Ferraz, Rosana P.C., Cardoso, Gabriella M.B., da Silva, Thanany B., Fontes, José Eraldo do N., Prata, Ana Paula do N., Carvalho, Adriana A., Moraes, Manoel O., Pessoa, Claudia, Costa, Emmanoel V., Bezerra, Daniel P.

“…•The essential oil contains (E)-caryophyllene as its major component.•The essential oil displays cytotoxicity to tumour cell lines.•The essential oil possesses…”
Get full text

Antiproliferative effects of lectins from Canavalia ensiformis and Canavalia brasiliensis in human leukemia cell lines by Faheina-Martins, Glaucia V., da Silveira, Alethéia Lacerda, Cavalcanti, Bruno C., Ramos, Márcio V., Moraes, Manoel O., Pessoa, Cláudia, Araújo, Demetrius A.M.

“…► We showed in vitro cytotoxicity of lectins on leukemic and mononuclear cells. ► The index of DNA damage was measured using comet assay. ► Changes in cell…”
Get full text

Synthesis, structural characterization, and cytotoxic evaluation of chalcone derivatives by N. Bandeira, Paulo, L. G. Lemos, Telma, S. Santos, Hélcio, C. S. de Carvalho, Mylena, P. Pinheiro, Daniel, O. de Moraes Filho, Manoel, Pessoa, Cláudia, W. A. Barros-Nepomuceno, Francisco, H. S. Rodrigues, Tigressa, R. V. Ribeiro, Paulo, S. Magalhães, Herbert, M. R. Teixeira, Alexandre

“…Chalcones containing amino or acetamide groups on ring A and electron donating/withdrawing groups on ring B have been shown to have great cytotoxic potential…”
Get full text

Antitumor Potential of the Isoflavonoids (+)- and (−)-2,3,9-Trimethoxypterocarpan: Mechanism-of-Action Studies by Farias, Kaio, da Costa, Roner F., Meira, Assuero S., Diniz-Filho, Jairo, Bezerra, Eveline M., Freire, Valder N., Guest, Prue, Nikahd, Maryam, Ma, Xinghua, Gardiner, Michael G., Banwell, Martin G., de Oliveira, Maria da C. F., de Moraes, Manoel O., do Ó Pessoa, Claudia

“…Synthetically derived samples of (+)-(6a S ,11a S )-2,3,9-trimethoxypterocarpan [(+)- 1 ] and its enantiomer [(−)- 1 ], both of which are examples of naturally…”
Get full text

Cytotoxic profile of natural and some modified bufadienolides from toad Rhinella schneideri parotoid gland secretion by Cunha-Filho, Geraldino A., Resck, Inês S., Cavalcanti, Bruno C., Pessoa, Cláudia Ó., Moraes, Manoel O., Ferreira, José R.O., Rodrigues, Felipe A.R., dos Santos, Maria L.

“…Cutaneous secretions of toad species are an important source of bufadienolides, compounds that exhibit interesting structural features and biopharmacological…”
Get full text

Folk uses and pharmacological properties of Casearia sylvestris: a medicinal review by Ferreira, Paulo Michel P, Costa-Lotufo, Leticia V, Moraes, Manoel O, Barros, Francisco W A, Martins, Aline M A, Cavalheiro, Alberto J, Bolzani, Vanderlan S, Santos, Andre G, Pessoa, Claudia

“…Folk uses and scientific investigations have highlighted the importance of Casearia sylvestris extracts and their relevant bioactive potential. The aim of this…”
Get full text

Tryptophan catabolites along the indoleamine 2,3-dioxygenase pathway as a biological link between depression and cancer by Barreto, Francisco S, Chaves Filho, Adriano J.M, de Araújo, Márcia C.C.R, de Moraes, Manoel O, de Moraes, Maria E.A, Maes, Michael, de Lucena, David F, Macedo, Danielle S

“…Both depression and cancer are related to a dysregulation of inflammatory and immune pathways. Indeed, depression is associated with increased expression of…”
Get full text

Casearin X exhibits cytotoxic effects in leukemia cells triggered by apoptosis by Ferreira, Paulo M. Pinheiro, Santos, André G., Tininis, Aristeu G., Costa, Patricia M., Cavalheiro, Alberto J., Bolzani, Vanderlan S., Moraes, Manoel O., Costa-Lotufo, Letícia V., Montenegro, Raquel C., Pessoa, Cláudia

“…Clerodane diterpenes have demonstrated cytotoxic, antiplasmodial and anti-ulcer properties. In the present work, we determined the cytotoxic effect of casearin…”
Get full text

Effect of essential oil of Alpinia zerumbet on cardiovascular and autonomic function in rats with isoproterenol induced acute myocardial infarction by HOLANDA, THAIS M., ROCHA, DANILO G., SILVEIRA, JOÃO ALISON M., COSTA, PAULA PRISCILA C., MAIA, PEDRO HENRIQUE F., INGRAM, CATHERINE, MORAES, MARIA ELISABETE A. DE, FECHINE, FRANCISCO V., MORAES FILHO, MANOEL O. DE

“…Abstract Alpinia zerumbet is a plant popularly used to treat hypertension and anxiety. Studies with Alpinia zerumbet demonstrate antihypertensive and…”
Get full text

Evaluation of the antifungal activity in vitro of midazolam against fluconazole-resistant Candida spp. isolates by Holanda, Maria Av, da Silva, Cecília R, de A Neto, João B, do Av Sá, Lívia G, do Nascimento, Francisca Bsa, Barroso, Daiana D, da Silva, Lisandra J, Cândido, Thiago M, Leitão, Amanda C, Barbosa, Amanda D, de Moraes, Manoel O, Cc, Bruno, Júnior, Hélio V Nobre

“…The purpose of this study was to evaluate the antifungal activity of midazolam, alone and in association with azoles, against isolates of clinical spp. in…”
Get full text

(+)- and (−)-Mutisianthol: First Total Synthesis, Absolute Configuration, and Antitumor Activity by Bianco, Graziela G., Ferraz, Helena M. C., Costa, Arinice M., Costa-Lotufo, Letícia V., Pessoa, Cláudia, de Moraes, Manoel O., Schrems, Marcus G., Pfaltz, Andreas, Silva, Luiz F.

“…The first synthesis of the natural product (+)-mutisianthol was accomplished in 11 steps and in 21% overall yield from 2-methylanisole. The synthesis of its…”
Get full text

Antiparasitic, Antineuroinflammatory, and Cytotoxic Polyketides from the Marine Sponge Plakortis angulospiculatus Collected in Brazil by Kossuga, Miriam H, Nascimento, Andréa M, Reimão, Juliana Q, Tempone, André G, Taniwaki, Noemi Nosomi, Veloso, Katyuscya, Ferreira, Antonio G, Cavalcanti, Bruno C, Pessoa, Claudia, Moraes, Manoel O, Mayer, Alejandro M. S, Hajdu, Eduardo, Berlinck, Roberto G. S

“…Investigation of the bioactive crude extract from the sponge Plakortis angulospiculatus from Brazil led to the isolation of plakortenone (1) as a new…”
Get full text

Antitumor properties of a sulfated polysaccharide from the red seaweed Champia feldmannii (Diaz-Pifferer) by Lins, Kézia O. A. L., Bezerra, Daniel P., Alves, Ana Paula N. N., Alencar, Nylane M. N., Lima, Michael W., Torres, Valeska M., Farias, Wladimir R. L., Pessoa, Cláudia, de Moraes, Manoel O., Costa-Lotufo, Letícia V.

“…In recent years, much attention has been focused on polysaccharides isolated from natural sources. The aim of this study was to investigate the in vitro and in…”
Get full text

Study of the antiproliferative potential of seed extracts from Northeastern Brazilian plants by Ferreira, Paulo Michel P, Farias, Davi F, Viana, Martônio P, Souza, Terezinha M, Vasconcelos, Ilka M, Soares, Bruno M, Pessoa, Cláudia, Costa-Lotufo, Letícia V, Moraes, Manoel O, Carvalho, Ana F U

“…This study assessed the antiproliferative and cytotoxic potential against tumor lines of ethanolic seed extracts of 21 plant species belonging to different…”
Get full text

Discovery of Phthalimides as Immunomodulatory and Antitumor Drug Prototypes by Pessoa, Claudia, Ferreira, Paulo Michel P., Lotufo, Letícia Veras C., de Moraes, Manoel O., Cavalcanti, Suellen M. T., Coêlho, Lucas Cunha D., Hernandes, Marcelo Z., Leite, Ana Cristina L., De Simone, Carlos A., Costa, Vlaudia M. A., Souza, Valdênia M. O.

“…Optimized anticancer agents: A set of functionalized phthalimides was synthesized and evaluated for antitumor activities and as modulators of the secretion of…”
Get full text

Antitumor Activity of the Essential Oil from the Leaves of Croton regelianus and Its Component Ascaridole by Bezerra, Daniel P., Filho, José D. B. Marinho, Alves, Ana Paula N. N., Pessoa, Cláudia, de Moraes, Manoel O., Pessoa, Otília Deusdênia L., Torres, Maria Conceição M., Silveira, Edilberto R., Viana, Francisco A., Costa-Lotufo, Letícia V.

“…Croton regelianus Muell. Arg., popularly known as ‘velame‐de‐cheiro’, is a native plant from the Northeast of Brazil used in folk medicine to treat diseases of…”
Get full text

Sensitive method for determination of piplartine, an alkaloid amide from Piper species, in rat plasma samples by liquid chromatography-tandem mass spectrometry by Bezerra, Daniel P., Pessoa, Cláudia, Moraes, Manoel O, Costa-Lotufo, Letícia V., Rubio Gouvea, Dayana, Jabor, Valquíria A. Polisel, Lopes, Norberto Peporine, Borges, Keyller Bastos, Lima, Mary Anne S., Silveira, Edilberto R.

“…Piplartine (PPTN) is an alkaloid amide found in Piper species that presents different activities. PPTN determination in rat plasma is necessary to better…”
Get full text

TP53 mutations in astrocytic gliomas: an association with histological grade, TP53 codon 72 polymorphism and p53 expression by Faria, Mario H. G., Neves Filho, Eduardo H. C., Alves, Markenia K. S., Burbano, Rommel M. R., de Moraes Filho, Manoel O., Rabenhorst, Silvia H. B.

“…TP53 mutations and polymorphisms have been widely related to many cancers as long as these alterations may impair its capacity to induce cell cycle arrest, DNA…”
Get full text