Search Results - "Mano, R"
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Topological and functional comparison of community detection algorithms in biological networks
Published in BMC bioinformatics (27-04-2019)“…Community detection algorithms are fundamental tools to uncover important features in networks. There are several studies focused on social networks but only a…”
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Serum microRNAs explain discordance of non-alcoholic fatty liver disease in monozygotic and dizygotic twins: a prospective study
Published in Gut (01-09-2016)“…In the setting where two individuals are genetically similar, epigenetic mechanisms could account for discordance in the presence or absence of non-alcoholic…”
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Enhancer-associated long non-coding RNA LEENE regulates endothelial nitric oxide synthase and endothelial function
Published in Nature communications (18-01-2018)“…The optimal expression of endothelial nitric oxide synthase (eNOS), the hallmark of endothelial homeostasis, is vital to vascular function. Dynamically…”
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Study protocol: ‘a large cohort study of postnatal events in a not-for-profit referral centre in Vellore, South India’
Published in BMJ open (19-12-2022)“…IntroductionIn a large developing country, with diverse population characteristics and differential access to healthcare, it is important to identify factors…”
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Modeling enzyme competition in eicosanoid metabolism in macrophage cells using a cybernetic framework
Published in Journal of lipid research (10-10-2024)“…Cellular metabolism is a complex process involving the consumption and production of metabolites, as well as the regulation of enzyme synthesis and activity…”
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Modular and mechanistic changes across stages of colorectal cancer
Published in BMC cancer (21-04-2022)“…While mechanisms contributing to the progression and metastasis of colorectal cancer (CRC) are well studied, cancer stage-specific mechanisms have been less…”
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Krüppel-Like Factor 4 Regulation of Cholesterol-25-Hydroxylase and Liver X Receptor Mitigates Atherosclerosis Susceptibility
Published in Circulation (New York, N.Y.) (03-10-2017)“…BACKGROUND:Atherosclerosis is a multifaceted inflammatory disease involving cells in the vascular wall (eg, endothelial cells [ECs]), as well as circulating…”
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The maternal blood lipidome is indicative of the pathogenesis of severe preeclampsia
Published in Journal of lipid research (01-01-2021)“…Preeclampsia is a pregnancy-specific syndrome characterized by hypertension and proteinuria after 20 weeks of gestation. However, it is not well understood…”
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Systems biology analysis of longitudinal functional response of endothelial cells to shear stress
Published in Proceedings of the National Academy of Sciences - PNAS (10-10-2017)“…Blood flow and vascular shear stress patterns play a significant role in inducing and modulating physiological responses of endothelial cells (ECs). Pulsatile…”
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miRNAs that Induce Human Cardiomyocyte Proliferation Converge on the Hippo Pathway
Published in Cell reports (Cambridge) (15-05-2018)“…Understanding the mechanisms that control human cardiomyocyte proliferation might be applicable to regenerative medicine. We screened a whole genome collection…”
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Longitudinal shear stress response in human endothelial cells to atheroprone and atheroprotective conditions
Published in Proceedings of the National Academy of Sciences - PNAS (26-01-2021)“…The two main blood flow patterns, namely, pulsatile shear (PS) prevalent in straight segments of arteries and oscillatory shear (OS) observed at branch points,…”
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The neural career of sensory-motor metaphors
Published in Journal of cognitive neuroscience (01-09-2011)“…The role of sensory-motor systems in conceptual understanding has been controversial. It has been proposed that many abstract concepts are understood…”
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Sensitivity of a tonne-scale NEXT detector for neutrinoless double-beta decay searches
Published in The journal of high energy physics (01-08-2021)“…A bstract The Neutrino Experiment with a Xenon TPC (NEXT) searches for the neutrinoless double-beta (0 νββ ) decay of 136 Xe using high-pressure xenon gas TPCs…”
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Biomarkers of NAFLD progression: a lipidomics approach to an epidemic
Published in Journal of lipid research (01-03-2015)“…The spectrum of nonalcoholic fatty liver disease (NAFLD) includes steatosis, nonalcoholic steatohepatitis (NASH), and cirrhosis. Recognition and timely…”
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Time varying causal network reconstruction of a mouse cell cycle
Published in BMC bioinformatics (29-05-2019)“…Biochemical networks are often described through static or time-averaged measurements of the component macromolecules. Temporal variation in these components…”
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Neutral Bremsstrahlung Emission in Xenon Unveiled
Published in Physical review. X (07-04-2022)“…We present evidence of non-excimer-based secondary scintillation in gaseous xenon, obtained using both the NEXT-White time projection chamber (TPC) and a…”
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MetGENE: gene-centric metabolomics information retrieval tool
Published in Gigascience (28-12-2022)“…Abstract Background Biomedical research often involves contextual integration of multimodal and multiomic data in search of mechanisms for improved diagnosis,…”
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Systematic Review of Dispositional Mindfulness and Posttraumatic Stress Disorder Symptomology: A Targeted Examination of Avoidance
Published in Trauma, Violence, & Abuse (01-10-2024)“…High rates of nonresponse to evidence-based treatment for posttraumatic stress disorder (PTSD) have fueled the search for improved intervention. Evidence…”
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Secondary scintillation yield in pure krypton
Published in Physics letters. B (10-01-2022)“…The absolute secondary scintillation yield is of paramount importance for modelling dual-phase or high-pressure gas detectors, to be used in contemporary and…”
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