Search Results - "Mannstadt, Michael"

Physiology of the Calcium-Parathyroid Hormone-Vitamin D Axis by Goltzman, David, Mannstadt, Michael, Marcocci, Claudio

“…Classic endocrine feedback loops ensure the regulation of blood calcium. Calcium in the extracellular fluid (ECF) binds and activates the calcium sensing…”
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Epidemiology and Diagnosis of Hypoparathyroidism by Clarke, Bart L, Brown, Edward M, Collins, Michael T, Jüppner, Harald, Lakatos, Peter, Levine, Michael A, Mannstadt, Michael M, Bilezikian, John P, Romanischen, Anatoly F, Thakker, Rajesh V

“…Context: Hypoparathyroidism is a disorder characterized by hypocalcemia due to insufficient secretion of PTH. Pseudohypoparathyroidism is a less common…”
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Parathyroid Hormone Directs Bone Marrow Mesenchymal Cell Fate by Fan, Yi, Hanai, Jun-ichi, Le, Phuong T., Bi, Ruiye, Maridas, David, DeMambro, Victoria, Figueroa, Carolina A., Kir, Serkan, Zhou, Xuedong, Mannstadt, Michael, Baron, Roland, Bronson, Roderick T., Horowitz, Mark C., Wu, Joy Y., Bilezikian, John P., Dempster, David W., Rosen, Clifford J., Lanske, Beate

“…Intermittent PTH administration builds bone mass and prevents fractures, but its mechanism of action is unclear. We genetically deleted the PTH/PTHrP…”
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Fibroblast Growth Factor 23 and Mortality among Patients Undergoing Hemodialysis by Gutiérrez, Orlando M, Mannstadt, Michael, Isakova, Tamara, Rauh-Hain, Jose Alejandro, Tamez, Hector, Shah, Anand, Smith, Kelsey, Lee, Hang, Thadhani, Ravi, Jüppner, Harald, Wolf, Myles

“…This study involving patients in whom hemodialysis was being initiated shows that increased levels of fibroblast growth factor 23 (FGF-23), a hormone that…”
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Effects of Phosphate Binders in Moderate CKD by BLOCK, Geoffrey A, WHEELER, David C, KOOIENGA, Laura, THADHANI, Ravi, MANNSTADT, Michael, WOLF, Myles, CHERTOW, Glenn M, PERSKY, Martha S, KESTENBAUM, Bryan, KETTELER, Markus, SPIEGEL, David M, ALLISON, Matthew A, ASPLIN, John, SMITS, Gerard, HOOFNAGLE, Andrew N

“…Some propose using phosphate binders in the CKD population given the association between higher levels of phosphorus and mortality, but their safety and…”
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Kidney glycolysis serves as a mammalian phosphate sensor that maintains phosphate homeostasis by Zhou, Wen, Simic, Petra, Zhou, Iris Y, Caravan, Peter, Vela Parada, Xavier, Wen, Donghai, Washington, Onica L, Shvedova, Maria, Pierce, Kerry A, Clish, Clary B, Mannstadt, Michael, Kobayashi, Tatsuya, Wein, Marc N, Jüppner, Harald, Rhee, Eugene P

“…How phosphate levels are detected in mammals is unknown. The bone-derived hormone fibroblast growth factor 23 (FGF23) lowers blood phosphate levels by reducing…”
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Rapid genomic changes by mineralotropic hormones and kinase SIK inhibition drive coordinated renal Cyp27b1 and Cyp24a1 expression via CREB modules by Meyer, Mark B., Benkusky, Nancy A., Lee, Seong Min, Yoon, Sung-Hee, Mannstadt, Michael, Wein, Marc N., Pike, J. Wesley

“…Vitamin D metabolism centers on kidney regulation of Cyp27b1 by mineralotropic hormones, including induction by parathyroid hormone (PTH), suppression by…”
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Pharmacological Interventions Targeting Pain in Fibrous Dysplasia/McCune-Albright Syndrome by Tucker-Bartley, Anthony, Selen, Daryl J, Golden, Emma, van Gool, Raquel, Ebb, David, Mannstadt, Michael, Upadhyay, Jaymin

“…Fibrous dysplasia (FD) is a rare, non-inherited bone disease occurring following a somatic gain-of-function R201 missense mutation of the ( gene. The spectrum…”
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Autosomal Dominant Hypocalcemia (Hypoparathyroidism) Types 1 and 2 by Roszko, Kelly L, Bi, Ruiye D, Mannstadt, Michael

“…Extracellular calcium is essential for life and its concentration in the blood is maintained within a narrow range. This is achieved by a feedback loop that…”
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Efficacy and safety of recombinant human parathyroid hormone (1–84) in hypoparathyroidism (REPLACE): a double-blind, placebo-controlled, randomised, phase 3 study by Mannstadt, Michael, Dr, Clarke, Bart L, MD, Vokes, Tamara, MD, Brandi, Maria Luisa, Prof, Ranganath, Lakshminarayan, MD, Fraser, William D, Prof, Lakatos, Peter, MD, Bajnok, Laszlo, MD, Garceau, Roger, MD, Mosekilde, Leif, Prof, Lagast, Hjalmar, MD, Shoback, Dolores, Prof, Bilezikian, John P, Prof

“…Summary Background Hypoparathyroidism results in impaired mineral homoeostasis, including hypocalcaemia and hyperphosphataemia. Treatment with high-dose oral…”
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Epigenetic profiling reveals key genes and cis-regulatory networks specific to human parathyroids by Jung, Youngsook Lucy, Zhao, Wenping, Li, Ian, Jain, Dhawal, Epstein, Charles B., Bernstein, Bradley E., Parangi, Sareh, Sherwood, Richard, Robinson-Cohen, Cassianne, Hsu, Yi-Hsiang, Park, Peter J., Mannstadt, Michael

“…In all terrestrial vertebrates, the parathyroid glands are critical regulators of calcium homeostasis and the sole source of parathyroid hormone (PTH)…”
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A parathyroid hormone/salt-inducible kinase signaling axis controls renal vitamin D activation and organismal calcium homeostasis by Yoon, Sung-Hee, Meyer, Mark B, Arevalo, Carlos, Tekguc, Murat, Zhang, Chengcheng, Wang, Jialiang S, Castro Andrade, Christian D, Strauss, Katelyn, Sato, Tadatoshi, Benkusky, Nancy A, Lee, Seong Min, Berdeaux, Rebecca, Foretz, Marc, Sundberg, Thomas B, Xavier, Ramnik J, Adelmann, Charles H, Brooks, Daniel J, Anselmo, Anthony, Sadreyev, Ruslan I, Rosales, Ivy A, Fisher, David E, Gupta, Navin, Morizane, Ryuji, Greka, Anna, Pike, J Wesley, Mannstadt, Michael, Wein, Marc N

“…The renal actions of parathyroid hormone (PTH) promote 1,25-vitamin D generation; however, the signaling mechanisms that control PTH-dependent vitamin D…”
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Total synthesis and structure–activity relationship studies of a series of selective G protein inhibitors by Xiong, Xiao-Feng, Zhang, Hang, Underwood, Christina R., Harpsøe, Kasper, Gardella, Thomas J., Wöldike, Mie F., Mannstadt, Michael, Gloriam, David E., Bräuner-Osborne, Hans, Strømgaard, Kristian

“…G proteins are key mediators of G protein-coupled receptor signalling, which facilitates a plethora of important physiological processes. The cyclic…”
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Interrelated role of Klotho and calcium-sensing receptor in parathyroid hormone synthesis and parathyroid hyperplasia by Fan, Yi, Liu, Weiqing, Bi, Ruiye, Densmore, Michael J., Sato, Tadatoshi, Mannstadt, Michael, Yuan, Quan, Zhou, Xuedong, Olauson, Hannes, Larsson, Tobias E., Toka, Hakan R., Pollak, Martin R., Brown, Edward M., Lanske, Beate

“…The pathogenesis of parathyroid gland hyperplasia is poorly understood, and a better understanding is essential if there is to be improvement over the current…”
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Effects of parathyroid hormone rhPTH(1–84) on phosphate homeostasis and vitamin D metabolism in hypoparathyroidism: REPLACE phase 3 study by Clarke, Bart L., Vokes, Tamara J., Bilezikian, John P., Shoback, Dolores M., Lagast, Hjalmar, Mannstadt, Michael

“…In hypoparathyroidism, inappropriately low levels of parathyroid hormone lead to unbalanced mineral homeostasis. The objective of this study was to determine…”
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Germline Mutations Affecting Gα11 in Hypoparathyroidism by Mannstadt, Michael, Harris, Mark, Bravenboer, Bert, Chitturi, Sridhar, Dreijerink, Koen M.A, Lambright, David G, Lim, Elaine T, Daly, Mark J, Gabriel, Stacey, Jüppner, Harald

“…In a study reported here, genomewide linkage analysis and whole-exome sequencing were used to identify two different heterozygous Gα11 mutations in…”
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P255: Gain-of-function CASR variants, a common genetic cause of non-surgical hypoparathyroidism: Findings from a sponsored genetic testing program by Mathew, Arun, Sridhar, Ananth, Roberts, Mary Scott, Smith, Lyndsay, Adler, Scott, Mannstadt, Michael

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Shadow on the mind: hypoparathyroidism's impact on brain and well-being by Mannstadt, Michael

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A Phase I Randomized Trial of Once‐Daily Versus Twice‐Daily Recombinant Human Parathyroid Hormone (1‐84) for Hypoparathyroidism by Ing, Steven W., Finkelman, Richard D., He, Ping, Khan, Aliya A., Mannstadt, Michael, Rejnmark, Lars, Song, Ivy, Takács, István, Wu, Yuna

“…ABSTRACT Recombinant human parathyroid hormone (1‐84), rhPTH(1‐84), is an approved adjunctive treatment to oral calcium and active vitamin D for adult patients…”
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Mutational analysis of GCMB, a parathyroid-specific transcription factor, in parathyroid adenoma of primary hyperparathyroidism by Mannstadt, Michael, Holick, Emily, Zhao, Wenping, Jüppner, Harald

“…Sporadic primary hyperparathyroidism (PHPT), one of the most common endocrine disorders, is characterized by hypercalcemia and elevated PTH levels. The…”
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