Search Results - "Manning, Sara L."

Tracheostomy Emergencies by Bontempo, Laura J., MD, MEd, Manning, Sara L., MD

“…Tracheostomy is a common procedure for long-term airway management. Although the overall complication rate is greater than 50%, the incidence of serious…”
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Effects of exercise on circulating tumor cells among patients with resected stage I-III colon cancer by Brown, Justin C, Rhim, Andrew D, Manning, Sara L, Brennan, Luke, Mansour, Alexandra I, Rustgi, Anil K, Damjanov, Nevena, Troxel, Andrea B, Rickels, Michael R, Ky, Bonnie, Zemel, Babette S, Courneya, Kerry S, Schmitz, Kathryn H

“…Physical activity is associated with a lower risk of disease recurrence among colon cancer patients. Circulating tumor cells (CTC) are prognostic of disease…”
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Does Albumin Infusion Reduce Renal Impairment and Mortality in Patients With Spontaneous Bacterial Peritonitis? by Jamtgaard, Louis, MD, Manning, Sara L., MD, Cohn, Brian, MD

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Spontaneous Irs1 passenger mutation linked to a gene-targeted SerpinB2 allele by Westrick, Randal J., Mohlke, Karen L., Korepta, Lindsey M., Yang, Angela Y., Zhu, Goujing, Manning, Sara L., Winn, Mary E., Dougherty, Kristiann M., Ginsburg, David

“…In characterizing mice with targeted disruption of the SerpinB2 gene, we observed animals that were small at birth with delayed growth and decreased life…”
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Homozygosity for factor V leiden leads to enhanced thrombosis and atherosclerosis in mice by EITZMAN, Daniel T, WESTRICK, Randal J, SHEN, Yuechun, BODARY, Peter F, SHUFANG GU, MANNING, Sara L, DOBIES, Sarah L, GINSBURG, David

“…Activated protein C resistance due to factor V Leiden (FVL) is a common genetic risk factor for venous thrombosis in humans. Although the impact of FVL on the…”
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A Programmable In Vivo CRISPR Activation Model Elucidates the Oncogenic and Immunosuppressive Functions of MYC in Lung Adenocarcinoma by Thege, Fredrik I, Rupani, Dhwani N, Barathi, Bhargavi Brahmendra, Manning, Sara L, Maitra, Anirban, Rhim, Andrew D, Wörmann, Sonja M

“…Conventional genetically engineered mouse models (GEMM) are time-consuming, laborious, and offer limited spatiotemporal control. Here, we describe the…”
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Multiplex Enrichment and Detection of Rare KRAS Mutations in Liquid Biopsy Samples using Digital Droplet Pre-Amplification by Pratt, Erica D, Cowan, Robert W, Manning, Sara L, Qiao, Edmund, Cameron, Heather, Schradle, Kara, Simeone, Diane M, Zhen, David B

“…Oncology research is increasingly incorporating molecular detection of circulating tumor DNA (ctDNA) as a tool for cancer surveillance and early detection…”
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Adar1 deletion causes degeneration of the exocrine pancreas via Mavs-dependent interferon signaling by Rupani, Dhwani N, Thege, Fredrik I, Chandra, Vidhi, Rajaei, Hajar, Cowan, Robert W, Wörmann, Sonja M, Le Roux, Olivereen, Malaney, Prerna, Manning, Sara L, Hashem, Jack, Bailey-Lundberg, Jennifer, Rhim, Andrew D, McAllister, Florencia

“…Adenosine deaminase acting on RNA 1 (ADAR1) is an RNA-binding protein that deaminates adenosine (A) to inosine (I). A-to-I editing alters post-transcriptional…”
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MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance by Farrell, Amy S., Joly, Meghan Morrison, Allen-Petersen, Brittany L., Worth, Patrick J., Lanciault, Christian, Sauer, David, Link, Jason, Pelz, Carl, Heiser, Laura M., Morton, Jennifer P., Muthalagu, Nathiya, Hoffman, Megan T., Manning, Sara L., Pratt, Erica D., Kendsersky, Nicholas D., Egbukichi, Nkolika, Amery, Taylor S., Thoma, Mary C., Jenny, Zina P., Rhim, Andrew D., Murphy, Daniel J., Sansom, Owen J., Crawford, Howard C., Sheppard, Brett C., Sears, Rosalie C.

“…Intratumoral phenotypic heterogeneity has been described in many tumor types, where it can contribute to drug resistance and disease recurrence. We analyzed…”
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Lethal perinatal thrombosis in mice resulting from the interaction of tissue factor pathway inhibitor deficiency and factor V Leiden by EITZMAN, Daniel T, WESTRICK, Randal J, XIAOMING BI, MANNING, Sara L, WILKINSON, John E, BROZE, George J, GINSBURG, David

“…Factor V Leiden (FVL) is a common genetic risk factor for thrombosis in humans. The incomplete penetrance of FVL suggests important contributions from other…”
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APOBEC3A drives deaminase domain-independent chromosomal instability to promote pancreatic cancer metastasis by Wörmann, Sonja M, Zhang, Amy, Thege, Fredrik I, Cowan, Robert W, Rupani, Dhwani N, Wang, Runsheng, Manning, Sara L, Gates, Chris, Wu, Weisheng, Levin-Klein, Rena, Rajapakshe, Kimal I, Yu, Meifang, Multani, Asha S, Kang, Ya'an, Taniguchi, Cullen M, Schlacher, Katharina, Bellin, Melena D, Katz, Matthew H G, Kim, Michael P, Fleming, Jason B, Gallinger, Steven, Maddipati, Ravikanth, Harris, Reuben S, Notta, Faiyaz, Ross, Susan R, Maitra, Anirban, Rhim, Andrew D

“…Despite efforts in understanding its underlying mechanisms, the etiology of chromosomal instability (CIN) remains unclear for many tumor types. Here, we…”
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Sensitized mutagenesis screen in Factor V Leiden mice identifies thrombosis suppressor loci by Westrick, Randal J., Tomberg, Kärt, Siebert, Amy E., Zhu, Guojing, Winn, Mary E., Dobies, Sarah L., Manning, Sara L., Brake, Marisa A., Cleuren, Audrey C., Hobbs, Linzi M., Mishack, Lena M., Johnston, Alexander J., Kotnik, Emilee, Siemieniak, David R., Xu, Jishu, Li, Jun Z., Saunders, Thomas L., Ginsburg, David

“…Factor V Leiden (F5L ) is a common genetic risk factor for venous thromboembolism in humans. We conducted a sensitized N-ethyl-N-nitrosourea (ENU) mutagenesis…”
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A Sensitized Genome-Wide ENU Mutagenesis Screen in the Mouse to Identify Genetic Modifiers of Thrombosis by Westrick, Randal J., Manning, Sara L., Dobies, Sarah L., Peterson, Abigail L., Siemieniak, David R., Korepta, Lindsey M., Ginsburg, David

“…Factor V Leiden, (FVL) is the most common known inherited thrombotic risk factor and is present in approximately 5% of most Western populations and 25–50% of…”
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