Search Results - "Manning, Samuel A"

Dynamic Fluctuations in Subcellular Localization of the Hippo Pathway Effector Yorkie In Vivo by Manning, Samuel A., Dent, Lucas G., Kondo, Shu, Zhao, Ziqing W., Plachta, Nicolas, Harvey, Kieran F.

“…The Hippo pathway is an evolutionarily conserved signaling network that integrates diverse cues to control organ size and cell fate. The central downstream…”
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A Drosophila RNAi library modulates Hippo pathway-dependent tissue growth by Vissers, Joseph H.A., Manning, Samuel A., Kulkarni, Aishwarya, Harvey, Kieran F.

“…Libraries of transgenic Drosophila melanogaster carrying RNA interference (RNAi) constructs have been used extensively to perform large-scale functional…”
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Homeodomain-Interacting Protein Kinase Regulates Hippo Pathway-Dependent Tissue Growth by Poon, Carole L.C., Zhang, Xiaomeng, Lin, Jane I., Manning, Samuel A., Harvey, Kieran F.

“…The Salvador-Warts-Hippo (SWH) pathway is an evolutionarily conserved regulator of tissue growth that is deregulated in human cancer [1–3]. Upstream SWH…”
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An in vivo large-scale chemical screening platform using Drosophila for anti-cancer drug discovery by Willoughby, Lee F, Schlosser, Tanja, Manning, Samuel A, Parisot, John P, Street, Ian P, Richardson, Helena E, Humbert, Patrick O, Brumby, Anthony M

“…Anti-cancer drug development involves enormous expenditure and risk. For rapid and economical identification of novel, bioavailable anti-tumour chemicals, the…”
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Warts Opens Up for Activation by Manning, Samuel A., Harvey, Kieran F.

“…Warts is the central effector kinase of the Hippo growth-control pathway. In this issue of Developmental Cell, by assessing Warts conformation in vivo,…”
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The dPix-Git complex is essential to coordinate epithelial morphogenesis and regulate myosin during Drosophila egg chamber development by Dent, Lucas G, Manning, Samuel A, Kroeger, Benjamin, Williams, Audrey M, Saiful Hilmi, Abdul Jabbar, Crea, Luke, Kondo, Shu, Horne-Badovinac, Sally, Harvey, Kieran F

“…How biochemical and mechanical information are integrated during tissue development is a central question in morphogenesis. In many biological systems, the…”
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The Hippo pathway uses different machinery to control cell fate and organ size by Pojer, Jonathan M., Manning, Samuel A., Kroeger, Benjamin, Kondo, Shu, Harvey, Kieran F.

“…The Hippo pathway is a conserved signaling network that regulates organ growth and cell fate. One such cell fate decision is that of R8 photoreceptor cells in…”
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The regulation of Yorkie, YAP and TAZ: new insights into the Hippo pathway by Manning, Samuel A, Kroeger, Benjamin, Harvey, Kieran F

“…The Hippo pathway is a highly conserved signalling pathway that regulates multiple biological processes, including organ size control and cell fate. Since its…”
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The Drosophila Hippo pathway transcription factor Scalloped and its co-factors alter each other's chromatin binding dynamics and transcription in vivo by Manning, Samuel A, Kroeger, Benjamin, Deng, Qiji, Brooks, Elliot, Fonseka, Yoshana, Hinde, Elizabeth, Harvey, Kieran F

“…The Hippo pathway is an important regulator of organ growth and cell fate. The major mechanism by which Hippo is known to control transcription is by dictating…”
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Basal spot junctions of Drosophila epithelial tissues respond to morphogenetic forces and regulate Hippo signaling by Kroeger, Benjamin, Manning, Samuel A, Fonseka, Yoshana, Oorschot, Viola, Crawford, Simon A, Ramm, Georg, Harvey, Kieran F

“…Organ size is controlled by numerous factors including mechanical forces, which are mediated in part by the Hippo pathway. In growing Drosophila epithelial…”
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