Search Results - "Manning, Joachim C."

Lectins: a primer for histochemists and cell biologists by Manning, Joachim C., Romero, Antonio, Habermann, Felix A., García Caballero, Gabriel, Kaltner, Herbert, Gabius, Hans-Joachim

“…An experimental observation on se lectin g binding partners underlies the introduction of the term ‘lectin’. Agglutination of erythrocytes depending on their…”
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Lectins: getting familiar with translators of the sugar code by André, Sabine, Kaltner, Herbert, Manning, Joachim C, Murphy, Paul V, Gabius, Hans-Joachim

“…The view on the significance of the presence of glycans in glycoconjugates is undergoing a paradigmatic change. Initially mostly considered to be rather inert…”
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What Cyto- and Histochemistry Can Do to Crack the Sugar Code by Habermann, Felix A., Kaltner, Herbert, Higuero, Alonso M., Caballero, Gabriel García, Ludwig, Anna-Kristin, Manning, Joachim C., Abad-Rodríguez, José, Gabius, Hans-Joachim

“…As letters form the vocabulary of a language, biochemical ‘symbols’ (the building blocks of oligo- and polymers) make writing molecular messages possible…”
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Tumor suppressor p16INK⁴a: Downregulation of galectin-3, an endogenous competitor of the pro-anoikis effector galectin-1, in a pancreatic carcinoma model by Sanchez-Ruderisch, Hugo, Fischer, Christian, Detjen, Katharina M, Welzel, Martina, Wimmel, Anja, Manning, Joachim C, André, Sabine, Gabius, Hans-Joachim

“…The tumor suppressor p16INK⁴a has functions beyond cell-cycle control via cyclin-dependent kinases. A coordinated remodeling of N- and O-glycosylation, and an…”
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Influence of protein (human galectin-3) design on aspects of lectin activity by García Caballero, Gabriel, Beckwith, Donella, Shilova, Nadezhda V., Gabba, Adele, Kutzner, Tanja J., Ludwig, Anna-Kristin, Manning, Joachim C., Kaltner, Herbert, Sinowatz, Fred, Cudic, Mare, Bovin, Nicolai V., Murphy, Paul V., Gabius, Hans-Joachim

“…The concept of biomedical significance of the functional pairing between tissue lectins and their glycoconjugate counterreceptors has reached the mainstream of…”
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How altering the modular architecture affects aspects of lectin activity: case study on human galectin-1 by Kutzner, Tanja J, Gabba, Adele, FitzGerald, Forrest G, Shilova, Nadezhda V, García Caballero, Gabriel, Ludwig, Anna-Kristin, Manning, Joachim C, Knospe, Clemens, Kaltner, Herbert, Sinowatz, Fred, Murphy, Paul V, Cudic, Mare, Bovin, Nicolai V, Gabius, Hans-Joachim

“…Discoveries on involvement of glycan-protein recognition in many (patho)physiological processes are directing attention to exploring the significance of a…”
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Galectin-related protein: An integral member of the network of chicken galectins 1. From strong sequence conservation of the gene confined to vertebrates to biochemical characteristics of the chicken protein and its crystal structure by García Caballero, Gabriel, Flores-Ibarra, Andrea, Michalak, Malwina, Khasbiullina, Nailya, Bovin, Nicolai V., André, Sabine, Manning, Joachim C., Vértesy, Sabine, Ruiz, Federico M., Kaltner, Herbert, Kopitz, Jürgen, Romero, Antonio, Gabius, Hans-Joachim

“…Endogenous lectins are multifunctional effectors in cell physiology. Adding the sixth member of the galectin family in chicken, a model organism for systematic…”
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Revealing biomedically relevant cell and lectin type-dependent structure-activity profiles for glycoclusters by using tissue sections as an assay platform by Kaltner, Herbert, Manning, Joachim C, García Caballero, Gabriel, Di Salvo, Claudia, Gabba, Adele, Romero-Hernández, Laura L, Knospe, Clemens, Wu, Dan, Daly, Harrison C, O'Shea, Donal F, Gabius, Hans-Joachim, Murphy, Paul V

“…The increasing realization of the involvement of lectin-glycan recognition in (patho)physiological processes inspires envisioning therapeutic intervention by…”
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Playing Modular Puzzle with Adhesion/Growth-Regulatory Galectins: Design and Testing of a Hybrid to Unravel Structure-Activity Relationships by Ludwig, Anna-Kristin, Vértesy, Sabine, Michalak, Malwina, Manning, Joachim C, Andre, Sabine, Kubler, Dieter, Kopitz, Jurgen, Kaltner, Herbert, Gabius, Hans-Joachim

“…The potent multifunctionality of human galectins is based on their modular structure in a not yet fully understood manner. A strategy to dissect the…”
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Prototype chicken galectins revisited: characterization of a third protein with distinctive hydrodynamic behaviour and expression pattern in organs of adult animals by Kaltner, Herbert, Solís, Dolores, Kopitz, Jürgen, Lensch, Martin, Lohr, Michaela, Manning, Joachim C, Mürnseer, Michael, Schnölzer, Martina, André, Sabine, Sáiz, José Luis, Gabius, Hans-Joachim

“…Prototype galectins are versatile modulators of cell adhesion and growth via their reactivity to certain carbohydrate and protein ligands. These functions and…”
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Galectins: their network and roles in immunity/tumor growth control by Kaltner, Herbert, Toegel, Stefan, Caballero, Gabriel García, Manning, Joachim C., Ledeen, Robert W., Gabius, Hans-Joachim

“…One route of realizing the information of glycans involves endogenous receptors (lectins). Occurrence at branch ends renders galactosides particularly…”
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The sweet side of wound healing: galectins as promising therapeutic targets in hemostasis, inflammation, proliferation, and maturation/remodeling by Čoma, Matúš, Manning, Joachim C, Kaltner, Herbert, Gál, Peter

“…Understanding the molecular and cellular processes involved in skin wound healing may pave the way for the development of innovative approaches to transforming…”
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How galectins have become multifunctional proteins by García Caballero, Gabriel, Kaltner, Herbert, Kutzner, Tanja J, Ludwig, Anna-Kristin, Manning, Joachim C, Schmidt, Sebastian, Sinowatz, Fred, Gabius, Hans-Joachim

“…Having identified glycans of cellular glycoconjugates as versatile molecular messages, their recognition by sugar receptors (lectins) is a fundamental…”
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Network analysis of adhesion/growth‐regulatory galectins and their binding sites in adult chicken retina and choroid by Manning, Joachim C., García Caballero, Gabriel, Knospe, Clemens, Kaltner, Herbert, Gabius, Hans‐Joachim

“…The highly ordered multilayered organization of the adult chicken retina is a suitable test model for examining zonal distribution of the members of a…”
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From glycophenotyping by (plant) lectin histochemistry to defining functionality of glycans by pairing with endogenous lectins by Kaltner, Herbert, García Caballero, Gabriel, Ludwig, Anna-Kristin, Manning, Joachim C., Gabius, Hans-Joachim

“…About 60 years ago, the efforts to identify blood group-specific haemagglutinins in plant extracts by broad-scale testing were beginning to make a large panel…”
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Tumour suppressor p16INK4a – anoikis‐favouring decrease in N/O‐glycan/cell surface sialylation by down‐regulation of enzymes in sialic acid biosynthesis in tandem in a pancreatic carcinoma model by Amano, Maho, Eriksson, Hanna, Manning, Joachim C., Detjen, Katharina M., André, Sabine, Nishimura, Shin‐Ichiro, Lehtiö, Janne, Gabius, Hans‐Joachim

“…Tumour suppressor p16INK4a is known to exert cell‐cycle control via cyclin‐dependent kinases. An emerging aspect of its functionality is the orchestrated…”
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Tumour suppressor p16(INK4a) - anoikis-favouring decrease in N/O-glycan/cell surface sialylation by down-regulation of enzymes in sialic acid biosynthesis in tandem in a pancreatic carcinoma model by Amano, Maho, Eriksson, Hanna, Manning, Joachim C, Detjen, Katharina M, André, Sabine, Nishimura, Shin-Ichiro, Lehtiö, Janne, Gabius, Hans-Joachim

“…Tumour suppressor p16(INK4a) is known to exert cell-cycle control via cyclin-dependent kinases. An emerging aspect of its functionality is the orchestrated…”
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Galectin-related protein: An integral member of the network of chicken galectins: 2. From expression profiling to its immunocyto- and histochemical localization and application as tool for ligand detection by Kaltner, Herbert, García Caballero, Gabriel, Sinowatz, Fred, Schmidt, Sebastian, Manning, Joachim C, André, Sabine, Gabius, Hans-Joachim

“…Galectin-related protein (GRP), present in vertebrates, is special within this family of adhesion/growth-regulatory proteins due to its strong positive…”
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Teaming up synthetic chemistry and histochemistry for activity screening in galectin-directed inhibitor design by Roy, René, Cao, Yihong, Kaltner, Herbert, Kottari, Naresh, Shiao, Tze Chieh, Belkhadem, Karima, André, Sabine, Manning, Joachim C., Murphy, Paul V., Gabius, Hans-Joachim

“…A hallmark of endogenous lectins is their ability to select a few distinct glycoconjugates as counterreceptors for functional pairing from the natural…”
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Targeting osteoarthritis-associated galectins and an induced effector class by a ditopic bifunctional reagent: Impact of its glycan part on binding measured in the tissue context by Manning, Joachim C., Baldoneschi, Veronica, Romero-Hernández, Laura L., Pichler, Katharina M., GarcÍa Caballero, Gabriel, André, Sabine, Kutzner, Tanja J., Ludwig, Anna-Kristin, Zullo, Valerio, Richichi, Barbara, Windhager, Reinhard, Kaltner, Herbert, Toegel, Stefan, Gabius, Hans-Joachim, Murphy, Paul V., Nativi, Cristina

“…[Display omitted] •Bivalency is integrated into a heterobifunctional galectin inhibitor.•Testing this lectin inhibitor on a tissue-based platform is…”
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