Search Results - "Mannick, Joan B."

Tackling immunosenescence to improve COVID-19 outcomes and vaccine response in older adults by Cox, Lynne S, Bellantuono, Ilaria, Lord, Janet M, Sapey, Elizabeth, Mannick, Joan B, Partridge, Linda, Gordon, Adam L, Steves, Claire J, Witham, Miles D

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Targeting the biology of ageing with mTOR inhibitors to improve immune function in older adults: phase 2b and phase 3 randomised trials by Mannick, Joan B, Teo, Grace, Bernardo, Patti, Quinn, Dean, Russell, Kerry, Klickstein, Lloyd, Marshall, William, Shergill, Sarb

“…The COVID-19 pandemic highlights the need for therapies that improve immune function in older adults, including interferon (IFN)-induced antiviral immunity…”
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Disruption of the M80-Fe ligation stimulates the translocation of cytochrome c to the cytoplasm and nucleus in nonapoptotic cells by Godoy, Luiz C, Muñoz-Pinedo, Cristina, Castro, Laura, Cardaci, Simone, Schonhoff, Christopher M, King, Michael, Tórtora, Verónica, Marín, Mónica, Miao, Qian, Jiang, Jian Fei, Kapralov, Alexandr, Jemmerson, Ronald, Silkstone, Gary G, Patel, Jinal N, Evans, James E, Wilson, Michael T, Green, Douglas R, Kagan, Valerian E, Radi, Rafael, Mannick, Joan B

“…Native cytochrome c (cyt c) has a compact tertiary structure with a hexacoordinated heme iron and functions in electron transport in mitochondria and apoptosis…”
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Targeting the biology of aging with mTOR inhibitors by Mannick, Joan B, Lamming, Dudley W

“…Inhibition of the protein kinase mechanistic target of rapamycin (mTOR) with the Food and Drug Administration (FDA)-approved therapeutic rapamycin promotes…”
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Fas-Induced Caspase Denitrosylation by Mannick, Joan B., Hausladen, Alfred, Liu, Limin, Hess, Douglas T., Zeng, Ming, Miao, Qian X., Kane, Laurie S., Gow, Andrew J., Stamler, Jonathan S.

“…Only a few intracellular S-nitrosylated proteins have been identified, and it is unknown if protein S-nitrosylation/denitrosylation is a component of signal…”
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Nitrosylation of Cytochrome c during Apoptosis by Schonhoff, Christopher M, Gaston, Benjamin, Mannick, Joan B

“…Cytochrome c released from mitochondria into the cytoplasm plays a critical role in many forms of apoptosis by stimulating apoptosome formation and subsequent…”
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S-Nitrosothiol Depletion in Amyotrophic Lateral Sclerosis by Schonhoff, Christopher M., Matsuoka, Masaaki, Tummala, Hemachand, Johnson, Michael A., Estevéz, Alvaro G., Wu, Rui, Kamaid, Andrés, Ricart, Karina C., Hashimoto, Yuichi, Gaston, Benjamin, Macdonald, Timothy L., Xu, Zuoshang, Mannick, Joan B.

“…Recent data suggest that either excessive or deficient levels of protein S-nitrosylation may contribute to disease. Disruption of S-nitrosothiol (SNO)…”
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mTOR inhibition improves immune function in the elderly by Mannick, Joan B, Del Giudice, Giuseppe, Lattanzi, Maria, Valiante, Nicholas M, Praestgaard, Jens, Huang, Baisong, Lonetto, Michael A, Maecker, Holden T, Kovarik, John, Carson, Simon, Glass, David J, Klickstein, Lloyd B

“…Inhibition of the mammalian target of rapamycin (mTOR) pathway extends life span in all species studied to date, and in mice delays the onset of age-related…”
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Short-term Low-Dose mTORC1 Inhibition in Aged Rats Counter-Regulates Age-Related Gene Changes and Blocks Age-Related Kidney Pathology by Shavlakadze, Tea, Zhu, Jiang, Wang, Sharon, Zhou, Weihua, Morin, Bret, Egerman, Marc A, Fan, Lin, Wang, Yanqun, Iartchouk, Oleg, Meyer, Angelika, Valdez, Reginald A, Mannick, Joan B, Klickstein, Lloyd B, Glass, David J

“…Rapalogs, inhibitors of mTORC1 (mammalian target of rapamycin complex 1), increase life span and delay age-related phenotypes in many species. However, the…”
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Fisetin for COVID‐19 in skilled nursing facilities: Senolytic trials in the COVID era by Verdoorn, Brandon P., Evans, Tamara K., Hanson, Gregory J., Zhu, Yi, Langhi Prata, Larissa G. P., Pignolo, Robert J., Atkinson, Elizabeth J., Wissler‐Gerdes, Erin O., Kuchel, George A., Mannick, Joan B., Kritchevsky, Stephen B., Khosla, Sundeep, Rizza, Stacey A., Walston, Jeremy D., Musi, Nicolas, Lipsitz, Lewis A., Kiel, Douglas P., Yung, Raymond, LeBrasseur, Nathan K., Singh, Ravinder J., McCarthy, Teresa, Puskarich, Michael A., Niedernhofer, Laura J., Robbins, Paul D., Sorenson, Matthew, Tchkonia, Tamara, Kirkland, James L.

“…The burden of senescent cells (SnCs), which do not divide but are metabolically active and resistant to death by apoptosis, is increased in older adults and…”
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S-Nitrosylation of Mitochondrial Caspases by Mannick, Joan B., Schonhoff, Christopher, Papeta, Natalia, Ghafourifar, Pedram, Szibor, Marten, Fang, Kezhong, Gaston, Benjamin

“…Caspase-3 is a cysteine protease located in both the cytoplasm and mitochondrial intermembrane space that is a central effector of many apoptotic pathways. In…”
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Nitrosylation: the next phosphorylation? by Mannick, Joan B, Schonhoff, Christopher M

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Nitric Oxide Inhibits Fas-induced Apoptosis by Mannick, Joan B., Miao, X. Qian, Stamler, Jonathan S.

“…The Fas antigen (CD95, APO-1) is a transmembrane cell surface receptor that mediates apoptosis of many cell types when bound by Fas ligand or cross-linked by…”
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Nitric oxide produced by human B lymphocytes inhibits apoptosis and Epstein-Barr virus reactivation by Mannick, J B, Asano, K, Izumi, K, Kieff, E, Stamler, J S

“…Nitric oxide (NO) produced by murine macrophages is important in murine resistance to ectromelia virus, herpes simplex virus, and vaccinia virus infection. In…”
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NO means no and yes: regulation of cell signaling by protein nitrosylation by Mannick, Joan B, Schonhoff, Christopher M

“…Protein nitrosylation is emerging as a key mechanism by which nitric oxide regulates cell signaling. Nitrosylation is the binding of a NO group to a metal or…”
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Measurement of protein S-nitrosylation during cell signaling by Mannick, Joan B, Schonhoff, Christopher M

“…S-Nitrosylation, the modification of a cysteine thiol by a nitric oxide (NO) group, has emerged as an important posttranslational modification of signaling…”
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Assessment of S-nitrosothiols on diaminofluorescein gels by King, Michael, Gildemeister, Otto, Gaston, Benjamin, Mannick, Joan B.

“…S-Nitrosylation is the modification of a cysteine thiol on a protein or peptide by a nitric oxide (NO) group. Increasing evidence suggests that S-nitrosylation…”
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Accelerated S-Nitrosothiol Breakdown by Amyotrophic Lateral Sclerosis Mutant Copper,Zinc-Superoxide Dismutase by Johnson, Michael A., Macdonald, Timothy L., Mannick, Joan B., Conaway, Mark R., Gaston, Benjamin

“…Mutations in copper,zinc-superoxide dismutase (SOD) have been implicated in familial amyotrophic lateral sclerosis (FALS). We have investigated the breakdown…”
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Analysis of protein S-nitrosylation by Mannick, Joan B, Schonhoff, Christopher M

“…S-nitrosylation is the binding of an NO group to a cysteine or other thiol. Like phosphorylation, S-nitrosylation is a precisely targeted and rapidly…”
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Nitric oxide modulates HIV-1 replication by Mannick, J B, Stamler, J S, Teng, E, Simpson, N, Lawrence, J, Jordan, J, Finberg, R W

“…Although nitric oxide (NO) production is increased in HIV-1-infected patients, and NO is known to inhibit the replication of several viruses, very little is…”
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