Search Results - "Mannheimer, Joshua D."

Predicting chemosensitivity using drug perturbed gene dynamics by Mannheimer, Joshua D, Prasad, Ashok, Gustafson, Daniel L

“…One of the current directions of precision medicine is the use of computational methods to aid in the diagnosis, prognosis, and treatment of disease based on…”
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A systematic analysis of genomics-based modeling approaches for prediction of drug response to cytotoxic chemotherapies by Mannheimer, Joshua D, Duval, Dawn L, Prasad, Ashok, Gustafson, Daniel L

“…The availability and generation of large amounts of genomic data has led to the development of a new paradigm in cancer treatment emphasizing a precision…”
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Transcriptional profiling of canine osteosarcoma identifies prognostic gene expression signatures with translational value for humans by Mannheimer, Joshua D., Tawa, Gregory, Gerhold, David, Braisted, John, Sayers, Carly M., McEachron, Troy A., Meltzer, Paul, Mazcko, Christina, Beck, Jessica A., LeBlanc, Amy K.

“…Canine osteosarcoma is increasingly recognized as an informative model for human osteosarcoma. Here we show in one of the largest clinically annotated canine…”
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Vinblastine pharmacokinetics in mouse, dog, and human in the context of a physiologically based model incorporating tissue‐specific drug binding, transport, and metabolism by Witta, Sandra, Collins, Keagan P., Ramirez, Dominique A., Mannheimer, Joshua D., Wittenburg, Luke A., Gustafson, Daniel L.

“…Vinblastine (VBL) is a vinca alkaloid‐class cytotoxic chemotherapeutic that causes microtubule disruption and is typically used to treat hematologic…”
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Vinca Alkaloid Pharmacokinetics in the Context of a Physiologically‐Based Murine Model by Collins, Keagan P., Mannheimer, Joshua D., Gustafson, Daniel L.

“…Vinca alkaloids are a class of molecule clinically used as cytotoxic chemotherapeutics, and exert their activity through mitotic disruption by preventing the…”
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Assessment of Modeling Techniques and Feature Selection for Predicting Drug Response from Gene Expression Data for Cytotoxic Anticancer Agents by Mannheimer, Joshua D., Prasad, Ashok, Duval, Dawn L., Gustafson, Daniel L.

“…Large amounts of genomics data being generated in vitro, in vivo, and clinically has led to statistical and mathematical modeling efforts to better understand…”
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Computational Approaches to Predict Drug Response to Cytotoxic Chemotherapy by Mannheimer, Joshua D

“…Cancer is the second leading cause of death in the united states. Statistically, within a lifetime there is slightly above a one-third chance of developing…”
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