Search Results - "Mannervik, Bengt"

Versatility of Glutathione Transferase Proteins by Mannervik, Bengt

“…For more than 60 years, glutathione transferases (GSTs) have attracted attention, but the research field of the GSTome [...]…”
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Role of human glutathione transferases in biotransformation of the nitric oxide prodrug JS-K by Sjödin, Birgitta, Mannervik, Bengt

“…Nitric oxide (NO) plays a prominent physiological role as a low-molecular-mass signal molecule involved in diverse biological functions. Great attention has…”
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A Preclinical Model for Parkinson's Disease Based on Transcriptional Gene Activation via KEAP1/NRF2 to Develop New Antioxidant Therapies by Segura-Aguilar, Juan, Mannervik, Bengt

“…Investigations of the effect of antioxidants on idiopathic Parkinson's disease have been unsuccessful because the preclinical models used to propose these…”
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Structure and steroid isomerase activity of Drosophila glutathione transferase E14 essential for ecdysteroid biosynthesis by Škerlová, Jana, Lindström, Helena, Gonis, Elodie, Sjödin, Birgitta, Neiers, Fabrice, Stenmark, Pål, Mannervik, Bengt

“…Ecdysteroids are critically important for the formation of the insect exoskeleton. Cholesterol is a precursor of ecdysone and its active form…”
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Characterization of Dog Glutathione Transferase P1-1, an Enzyme Relevant to Veterinary Medicine by Ismail, Aram, Lewis, Elizabeth, Sjödin, Birgitta, Mannervik, Bengt

“…Glutathione transferases (GSTs) form a family of detoxication enzymes instrumental in the inactivation and elimination of electrophilic mutagenic and…”
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Potent GST Ketosteroid Isomerase Activity Relevant to Ecdysteroidogenesis in the Malaria Vector Anopheles gambiae by Musdal, Yaman, Ismail, Aram, Sjödin, Birgitta, Mannervik, Bengt

“…Nobo is a glutathione transferase (GST) crucially contributing to ecdysteroid biosynthesis in insects of the orders and . Ecdysone is a vital steroid hormone…”
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Synthesis and Characterization of a Series of Highly Fluorogenic Substrates for Glutathione Transferases, a General Strategy by Zhang, Jie, Shibata, Aya, Ito, Mika, Shuto, Satoshi, Ito, Yoshihiro, Mannervik, Bengt, Abe, Hiroshi, Morgenstern, Ralf

“…Glutathione transferases (GSTs) are used in biotechnology applications as fusion partners for facile purification and are also overexpressed in certain tumors…”
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Potent inhibitors of equine steroid isomerase EcaGST A3-3 by Lindström, Helena, Mazari, Aslam M A, Musdal, Yaman, Mannervik, Bengt

“…Equine glutathione transferase A3-3 (EcaGST A3-3) belongs to the superfamily of detoxication enzymes found in all higher organisms. However, it is also the…”
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Marmoset glutathione transferases with ketosteroid isomerase activity by Ismail, Aram, Sawmi, Julia, Mannervik, Bengt

“…The common marmoset Callithrix jacchus encodes two glutathione transferase (GST) enzymes with ketosteroid double-bond isomerase activity. The most active…”
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Astrocytes protect dopaminergic neurons against aminochrome neurotoxicity by Segura-Aguilar, Juan, Mannervik, Bengt, Inzunza, José, Varshney, Mukesh, Nalvarte, Ivan, Muñoz, Patricia

“…Astrocytes protect neurons by modulating neuronal function and survival. Astrocytes support neurons in several ways. They provide energy through the…”
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FDA-approved drugs and other compounds tested as inhibitors of human glutathione transferase P1-1 by Musdal, Yaman, Hegazy, Usama M, Aksoy, Yasemin, Mannervik, Bengt

“…Glutathione transferase P1-1 (GST P1-1) is often overexpressed in tumor cells and is regarded as a contributor to their drug resistance. Inhibitors of GST P1-1…”
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Enzymatic Detoxication, Conformational Selection, and the Role of Molten Globule Active Sites by Honaker, Matthew T., Acchione, Mauro, Zhang, Wei, Mannervik, Bengt, Atkins, William M.

“…The role of conformational ensembles in enzymatic reactions remains unclear. Discussion concerning “induced fit” versus “conformational selection” has,…”
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Structural Basis for Featuring of Steroid Isomerase Activity in Alpha Class Glutathione Transferases by Tars, Kaspars, Olin, Birgit, Mannervik, Bengt

“…Glutathione transferases (GSTs) are abundant enzymes catalyzing the conjugation of hydrophobic toxic substrates with glutathione. In addition to detoxication,…”
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Conservation of Glutathione Transferase mRNA and Protein Sequences Similar to Human and Horse Alpha Class GST A3-3 across Dog, Goat, and Opossum Species by Hubert, Shawna M, Samollow, Paul B, Lindström, Helena, Mannervik, Bengt, Ing, Nancy H

“…The glutathione transferase A3-3 (GST A3-3) homodimeric enzyme is the most efficient enzyme that catalyzes isomerization of the precursors of testosterone,…”
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Expression of a Drosophila glutathione transferase in Arabidopsis confers the ability to detoxify the environmental pollutant, and explosive, 2,4,6-trinitrotoluene by Tzafestas, Kyriakos, Razalan, Maria M., Gyulev, Ivan, Mazari, Aslam M. A., Mannervik, Bengt, Rylott, Elizabeth L., Bruce, Neil C.

“…The explosive 2,4,6-trinitrotoluene (TNT) is a significant, global environmental pollutant that is both toxic and recalcitrant to degradation. Given the sheer…”
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Glutathione Transferase-M2-2 Secreted from Glioblastoma Cell Protects SH-SY5Y Cells from Aminochrome Neurotoxicity by Cuevas, Carlos, Huenchuguala, Sandro, Muñoz, Patricia, Villa, Monica, Paris, Irmgard, Mannervik, Bengt, Segura-Aguilar, Juan

“…U373MG cells are able to take up aminochrome that induces glutathione transferase M2-2 (GSTM2) expression in a concentration-dependent manner where 100 µM…”
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Glutathione Transferases as Efficient Ketosteroid Isomerases by Mannervik, Bengt, Ismail, Aram, Lindström, Helena, Sjödin, Birgitta, Ing, Nancy H

“…In addition to their well-established role in detoxication, glutathione transferases (GSTs) have other biological functions. We are focusing on the ketosteroid…”
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Divergent activities of human glutathione transferases in the bioactivation of azathioprine by Eklund, Birgitta I, Moberg, My, Bergquist, Jonas, Mannervik, Bengt

“…Azathioprine is a thiopurine prodrug clinically used for immunosuppression in the treatment of inflammatory diseases and in pharmacological regimens of organ…”
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Neuroprotection against Aminochrome Neurotoxicity: Glutathione Transferase M2-2 and DT-Diaphorase by Segura-Aguilar, Juan, Muñoz, Patricia, Inzunza, Jose, Varshney, Mukesh, Nalvarte, Ivan, Mannervik, Bengt

“…Glutathione is an important antioxidant that plays a crucial role in the cellular protection against oxidative stress and detoxification of electrophilic…”
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Minor Modifications of the C-terminal Helix Reschedule the Favored Chemical Reactions Catalyzed by Theta Class Glutathione Transferase T1-1 by Shokeer, Abeer, Mannervik, Bengt

“…Adaptive responses to novel toxic challenges provide selective advantages to organisms in evolution. Glutathione transferases (GSTs) play a pivotal role in the…”
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