Search Results - "Manners, Carol N"

Discovery and synthesis of methyl 2,5-dimethyl-4-[2-(phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylate (FPL 64176) and analogs: the first examples of a new class of calcium channel activator by Baxter, Andrew J. G, Dixon, John, Ince, Francis, Manners, Carol N, Teague, Simon J

“…Methyl 2,5-dimethyl-4-[2-(phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylate, FPL 64176 (1), is the first example of a new class of calcium channel activator (CCA)…”
Get full text

Distribution coefficient, a convenient term for the relation of predictable physico-chemical properties to metabolic processes by Manners, C N, Payling, D W, Smith, D A

“…1. The consequences of metabolic transformation on lipophilicity have been considered using the terms log P (partition coefficient) and log D (distribution…”
Get more information

Design, synthesis, and physicochemical properties of a novel, conformationally restricted 2,3-dihydro-1,3,4-thiadiazole-containing angiotensin converting enzyme inhibitor which is preferentially eliminated by the biliary route in rats by Bennion, Colin, Brown, Roger C, Cook, Anthony R, Manners, Carol N, Payling, David W, Robinson, David H

“…Two novel series of dihydrothiadiazole ring containing inhibitors of angiotensin converting enzyme have been designed and synthesized. The compounds are highly…”
Get full text

Predictive structure-activity relationships in a series of pyranoquinoline derivatives. A new primate model for the identification of antiallergic activity by Gould, Ken J, Manners, Carol N, Payling, David W, Suschitzky, John L, Wells, Edward

“…A new primate model has been developed for the evaluation of antiallergic agents. Compounds are tested for their ability to inhibit anti-IgE induced histamine…”
Get full text

Partitioning of ionizing molecules between aqueous buffers and phospholipid vesicles by Austin, R P, Davis, A M, Manners, C N

“…The distribution of four ionizing molecules between small unilamellar vesicles of dimyristoylphosphatidylcholine (DMPC) and aqueous buffers has been studied as…”
Get more information

The effect of ionic strength on liposome-buffer and 1-octanol-buffer distribution coefficients by Austin, R P, Barton, P, Davis, A M, Manners, C N, Stansfield, M C

“…The distribution of salmeterol and proxicromil between unilamellar vesicles of dioleoylphosphatidylcholine (DOPC) and aqueous buffer at pH 7.4 has been…”
Get more information

Gastrointestinal absorption of the strongly acidic drug proxicromil by Davis, M G, Manners, C N, Payling, D W, Smith, D A, Wilson, C A

“…Gastrointestinal absorption of the strongly acidic drug proxicromil has been studied with respect to its physical organic chemistry. The lipophilicity of the…”
Get more information