Search Results - "Mannering, G J"

The pharmacology and toxicology of the interferons: an overview by Mannering, G J, Deloria, L B

“…Interferon was discovered three decades ago. The next 20 or more years of research were directed largely toward an understanding of its antiviral activity. The…”
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Induction of murine cytochrome P4503A by the lichen constituents usnic and vulpinic acids by Mannering, G J, Shoeman, J A

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Interferon induces sleep and other CNS responses in mice recovering from hexobarbital anesthesia by Deloria, L B, Mannering, G J

“…Immediately after recovery from hexobarbital anesthesia, mice were injected intraperitoneally with one of the following interferons: natural mouse alpha/beta,…”
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Identification of the antibiotic hops component, colupulone, as an inducer of hepatic cytochrome P-4503A in the mouse by Mannering, G J, Shoeman, J A, Deloria, L B

“…A higher level of cytochrome P-450 (P450)-dependent ethylmorphine (EM) N-demethylase activity was observed in hepatic microsomes from mice fed a…”
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Lipid peroxidation-cytochrome P450 interactions. Use of linoleic acid hydroperoxide in the characterization of the spin-state of membrane-bound P450 by Iba, M M, Gander, J E, Mannering, G J

“…1. A procedure (linolenic acid hydroperoxide (LAHP) deletion method) is described in which LAHP is added to the reference cuvette of a pair of spectrally…”
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Depression of the hepatic cytochrome P-450 monooxygenase system by treatment of mice with the antineoplastic agent 5-azacytidine by GOODERHAM, N. J, MANNERING, G. J

“…The effects of 5-azacytidine (5-AC) administration on the hepatic cytochrome P-450 systems of mice were studied. A single i.p. dose of 5-AC (25 mg/kg) to male…”
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Role of xanthine oxidase in the interferon-mediated depression of the hepatic cytochrome P-450 system in mice by MANNERING, G. J, DELORIA, L. B, ABBOTT, V

“…Interferon, interferon inducers, and a variety of other immunomodulators are known to depress the hepatic cytochrome P-450 drug-metabolizing system. Two…”
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Murine cytochrome P4503A is induced by 2-methyl-3-buten-2-ol, 3-methyl-1-pentyn-3-ol(meparfynol), and tert-amyl alcohol by Mannering, G J, Shoeman, J A

“…1. Colupulone, a constituent of hops, was shown to be a potent inducer of hepatic P4503A in mouse. The olefin, 2-methyl-3-buten-2-ol (RC = CH2), is formed from…”
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Effects of colupulone, a component of hops and brewers yeast, and chromium on glucose tolerance and hepatic cytochrome P450 in nondiabetic and spontaneously diabetic mice by Mannering, G J, Shoeman, J A, Shoeman, D W

“…Brewers yeast contains factors that increase and decrease glucose tolerance. Hop components (lupulones) that adhere to yeast during the brewing process elicit…”
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Interaction of constitutive and phenobarbital-induced cytochrome P-450 isozymes during the sequential oxidation of benzphetamine. Explanation for the difference in benzphetamine-induced hydrogen peroxide production and 455-nm complex formation in microsomes from untreated and phenobarbital-treated rats by Jeffery, E H, Mannering, G J

“…The following pathway for benzphetamine (Bz) metabolism in rat hepatic microsomes was established: Bz leads to norbenzphetamine (NorBz) leads to…”
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Induction of xanthine oxidase and depression of cytochrome P-450 by interferon inducers: genetic difference in the responses of mice by Deloria, L, Abbott, V, Gooderham, N, Mannering, G J

“…Interferon and interferon inducing agents depress hepatic cytochrome P-450 systems. They also induce hepatic xanthine oxidase activity. It has been suggested…”
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Role of phospholipids in the hepatic microsomal drug-metabolizing system by Chaplin, M D, Mannering, G J

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Depression of the hepatic cytochrome P-450 mono-oxygenase system by administered tilorone (2,7-bis(2-(diethylamino)ethoxy)fluoren-9-one dihydrochloride) by Renton, K W, Mannering, G J

“…The oral administration of the antiviral agent, tilorone-HCl (50 mg/day for 4 days) to rats caused losses of hepatic microsomal ethylmorphine N-demethylase,…”
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Species, sex, and developmental differences in the O- and N-dealkylation of ethylmorphine by hepatic microsomes by Nerland, D E, Mannering, G J

“…3-O-[1'-14C]Ethylmorphine and ethylmorphine, respectively, were used to measure O- and N-dealkylase activities of hepatic microsomes. The well-known sex…”
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Involvement of a hydrophobic site in the inhibition of the microsomal p-hydroxylation of aniline by alcohols by Cohen, G M, Mannering, G J

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Evidence for a predominantly NADH-dependent O-dealkylating system in rat hepatic microsomes by Kuwahara, S, Mannering, G J

“…This study compared the NADH- and NADPH-supported p-nitrophenetole (NP) O-deethylase, ethylmorphine (EM) O-deethylase and EM N-demethylase activities of rat…”
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Two-substrate kinetics of drug-metabolizing enzyme systems of hepatic microsomes by Alvares, A P, Mannering, G J

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Membrane bound cytochrome P-450 determines the optimal temperatures of NADPH-cytochrome P-450 reductase and cytochrome P-450-linked monooxygenase reactions in rat and trout hepatic microsomes by Gurumurthy, P, Mannering, G J

“…The hepatic monooxygenase systems largely responsible for the biotransformation of drugs and other xenobiotics are comprised of NADPH-cytochrome P-450…”
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DPNH synergism of TPNH-dependent mixed function oxidase reactions by Correia, M A, Mannering, G J

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Induction of drug metabolism. I. Differences in the mechanisms by which polycyclic hydrocarbons and phenobarbital produce their inductive effects on microsomal N-demethylating systems by Sladek, N E, Mannering, G J

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