Search Results - "Mannepalli, Seetha"

DIP/Dpr interactions and the evolutionary design of specificity in protein families by Sergeeva, Alina P., Katsamba, Phinikoula S., Cosmanescu, Filip, Brewer, Joshua J., Ahlsen, Goran, Mannepalli, Seetha, Shapiro, Lawrence, Honig, Barry

“…Differential binding affinities among closely related protein family members underlie many biological phenomena, including cell-cell recognition. Drosophila…”
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Modular basis for potent SARS-CoV-2 neutralization by a prevalent VH1-2-derived antibody class by Rapp, Micah, Guo, Yicheng, Reddem, Eswar R., Yu, Jian, Liu, Lihong, Wang, Pengfei, Cerutti, Gabriele, Katsamba, Phinikoula, Bimela, Jude S., Bahna, Fabiana A., Mannepalli, Seetha M., Zhang, Baoshan, Kwong, Peter D., Huang, Yaoxing, Ho, David D., Shapiro, Lawrence, Sheng, Zizhang

“…Antibodies with heavy chains that derive from the VH1-2 gene constitute some of the most potent severe acute respiratory syndrome coronavirus 2…”
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Visualization of clustered protocadherin neuronal self-recognition complexes by Brasch, Julia, Goodman, Kerry M., Noble, Alex J., Rapp, Micah, Mannepalli, Seetha, Bahna, Fabiana, Dandey, Venkata P., Bepler, Tristan, Berger, Bonnie, Maniatis, Tom, Potter, Clinton S., Carragher, Bridget, Honig, Barry, Shapiro, Lawrence

“…Neurite self-recognition and avoidance are fundamental properties of all nervous systems 1 . These processes facilitate dendritic arborization 2 , 3 , prevent…”
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Molecular Logic of Neuronal Self-Recognition through Protocadherin Domain Interactions by Rubinstein, Rotem, Thu, Chan Aye, Goodman, Kerry Marie, Wolcott, Holly Noelle, Bahna, Fabiana, Mannepalli, Seetha, Ahlsen, Goran, Chevee, Maxime, Halim, Adnan, Clausen, Henrik, Maniatis, Tom, Shapiro, Lawrence, Honig, Barry

“…Self-avoidance, a process preventing interactions of axons and dendrites from the same neuron during development, is mediated in vertebrates through the…”
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How clustered protocadherin binding specificity is tuned for neuronal self-/nonself-recognition by Goodman, Kerry Marie, Katsamba, Phinikoula S, Rubinstein, Rotem, Ahlsén, Göran, Bahna, Fabiana, Mannepalli, Seetha, Dan, Hanbin, Sampogna, Rosemary V, Shapiro, Lawrence, Honig, Barry

“…The stochastic expression of fewer than 60 clustered protocadherin (cPcdh) isoforms provides diverse identities to individual vertebrate neurons and a…”
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Robust Prediction of Relative Binding Energies for Protein–Protein Complex Mutations Using Free Energy Perturbation Calculations by Sampson, Jared M., Cannon, Daniel A., Duan, Jianxin, Epstein, Jordan C.K., Sergeeva, Alina P., Katsamba, Phinikoula S., Mannepalli, Seetha M., Bahna, Fabiana A., Adihou, Hélène, Guéret, Stéphanie M., Gopalakrishnan, Ranganath, Geschwindner, Stefan, Rees, D. Gareth, Sigurdardottir, Anna, Wilkinson, Trevor, Dodd, Roger B., De Maria, Leonardo, Mobarec, Juan Carlos, Shapiro, Lawrence, Honig, Barry, Buchanan, Andrew, Friesner, Richard A., Wang, Lingle

“…[Display omitted] •Reliable calculation of relative binding free energy changes for most protein mutations to within ∼1 kcal/mol.•Automated Protein FEP+ Groups…”
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γ-Protocadherin structural diversity and functional implications by Goodman, Kerry Marie, Rubinstein, Rotem, Thu, Chan Aye, Mannepalli, Seetha, Bahna, Fabiana, Ahlsén, Göran, Rittenhouse, Chelsea, Maniatis, Tom, Honig, Barry, Shapiro, Lawrence

“…Stochastic cell-surface expression of α-, β-, and γ-clustered protocadherins (Pcdhs) provides vertebrate neurons with single-cell identities that underlie…”
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Affinity requirements for control of synaptic targeting and neuronal cell survival by heterophilic IgSF cell adhesion molecules by Xu, Shuwa, Sergeeva, Alina P., Katsamba, Phinikoula S., Mannepalli, Seetha, Bahna, Fabiana, Bimela, Jude, Zipursky, S. Lawrence, Shapiro, Lawrence, Honig, Barry, Zinn, Kai

“…Neurons in the developing brain express many different cell adhesion molecules (CAMs) on their surfaces. CAM-binding affinities can vary by more than 200-fold,…”
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Synaptogenic activity of the axon guidance molecule Robo2 underlies hippocampal circuit function by Blockus, Heike, Rolotti, Sebi V., Szoboszlay, Miklos, Peze-Heidsieck, Eugénie, Ming, Tiffany, Schroeder, Anna, Apostolo, Nuno, Vennekens, Kristel M., Katsamba, Phinikoula S., Bahna, Fabiana, Mannepalli, Seetha, Ahlsen, Goran, Honig, Barry, Shapiro, Lawrence, de Wit, Joris, Losonczy, Attila, Polleux, Franck

“…Synaptic connectivity within adult circuits exhibits a remarkable degree of cellular and subcellular specificity. We report that the axon guidance receptor…”
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Molecular basis of sidekick-mediated cell-cell adhesion and specificity by Goodman, Kerry M, Yamagata, Masahito, Jin, Xiangshu, Mannepalli, Seetha, Katsamba, Phinikoula S, Ahlsén, Göran, Sergeeva, Alina P, Honig, Barry, Sanes, Joshua R, Shapiro, Lawrence

“…Sidekick (Sdk) 1 and 2 are related immunoglobulin superfamily cell adhesion proteins required for appropriate synaptic connections between specific subtypes of…”
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Crystal structures of Drosophila N-cadherin ectodomain regions reveal a widely used class of Ca2+-free interdomain linkers by Jin, Xiangshu, Walker, Melissa A, Felsövályi, Klára, Vendome, Jeremie, Bahna, Fabiana, Mannepalli, Seetha, Cosmanescu, Filip, Ahlsen, Goran, Honig, Barry, Shapiro, Lawrence

“…Vertebrate classical cadherins mediate selective calcium-dependent cell adhesion by mechanisms now understood at the atomic level. However, structures and…”
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Free Energy Perturbation Calculations of Mutation Effects on SARS-CoV-2 RBD::ACE2 Binding Affinity by Sergeeva, Alina P., Katsamba, Phinikoula S., Liao, Junzhuo, Sampson, Jared M., Bahna, Fabiana, Mannepalli, Seetha, Morano, Nicholas C., Shapiro, Lawrence, Friesner, Richard A., Honig, Barry

“…[Display omitted] •Effects of mutations on RBD::ACE2 binding are calculated and tested experimentally.•Free energy perturbation (FEP) produces the most…”
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Structural Basis of Diverse Homophilic Recognition by Clustered α- and β-Protocadherins by Goodman, Kerry Marie, Rubinstein, Rotem, Thu, Chan Aye, Bahna, Fabiana, Mannepalli, Seetha, Ahlsén, Göran, Rittenhouse, Chelsea, Maniatis, Tom, Honig, Barry, Shapiro, Lawrence

“…Clustered protocadherin proteins (α-, β-, and γ-Pcdhs) provide a high level of cell-surface diversity to individual vertebrate neurons, engaging in highly…”
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Protocadherin cis-dimer architecture and recognition unit diversity by Goodman, Kerry M., Rubinstein, Rotem, Dan, Hanbin, Bahna, Fabiana, Mannepalli, Seetha, Ahlsén, Göran, Thu, Chan Aye, Sampogna, Rosemary V., Maniatis, Tom, Honig, Barry, Shapiro, Lawrence

“…Clustered protocadherins (Pcdhs) mediate numerous neural patterning functions, including neuronal self-recognition and non–selfdiscrimination to direct…”
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Clustered protocadherin molecular assembly and implications for neuronal self-avoidance by Goodman, Kerry Marie, Rubinstein, Rotem, Brasch, Julia, Mannepalli, Seetha, Bahna, Fabiana, Dan, Hanbin, Maniatis, Tom, Honig, Barry, Shapiro, Lawrence

“…Abstract only…”
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Structural Basis of Diverse Homophilic Recognition by Clustered [alpha]- and [beta]-Protocadherins by Goodman, Kerry Marie, Rubinstein, Rotem, Thu, Chan Aye, Bahna, Fabiana, Mannepalli, Seetha, Ahlsén, Göran, Rittenhouse, Chelsea, Maniatis, Tom, Honig, Barry, Shapiro, Lawrence

“…Clustered protocadherin proteins (α-, β-, and γ-Pcdhs) provide a high level of cell-surface diversity to individual vertebrate neurons, engaging in highly…”
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Clustered protocadherin molecular assembly and implications for neuronal self-avoidance by Goodman, Kerry M., Rubinstein, Rotem, Brasch, Julia, Thu, Chan Aye, Bahna, Fabiana, Mannepalli, Seetha, Dan, Hanbin, Sampogna, Rosemary V., Maniatis, Tom, Honig, Barry, Shapiro, Lawrence

“…Abstract only…”
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Crystal structures of Drosophila N-cadherin ectodomain regions reveal a widely used class of Ca^sup 2+^-free interdomain linkers by Jin, Xiangshu, Walker, Melissa A, Felsövályi, Klára, Vendome, Jeremie, Bahna, Fabiana, Mannepalli, Seetha, Cosmanescu, Filip, Ahlsen, Goran, Honig, Barry, Shapiro, Lawrence

“…Vertebrate classical cadherins mediate selective calcium-dependent cell adhesion by mechanisms now understood at the atomic level. However, structures and…”
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Crystal structures of Drosophila N-cadherin ectodomain regions reveal a widely used class of Ca 2+ -free interdomain linkers by Jin, Xiangshu, Walker, Melissa A., Felsövályi, Klára, Vendome, Jeremie, Bahna, Fabiana, Mannepalli, Seetha, Cosmanescu, Filip, Ahlsen, Goran, Honig, Barry, Shapiro, Lawrence

“…Vertebrate classical cadherins mediate selective calcium-dependent cell adhesion by mechanisms now understood at the atomic level. However, structures and…”
Get full text

Crystal structures of Drosophila N-cadherin ectodomain regions reveal a widely used class of Ca2+-free interdomain linkers by Jin, Xiangshu, Walker, Melissa A., Felsövályi, Klára, Vendome, Jeremie, Bahna, Fabiana, Mannepalli, Seetha, Cosmanescu, Filip, Ahlsen, Goran, Honig, Barry, Shapiro, Lawrence

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