Search Results - "Mann, MA"

Serotonin 1A Receptor Binding of [[.sup.11]C]CUMI-101 in Bipolar Depression Quantified Using Positron Emission Tomography: Relationship to Psychopathology and Antidepressant Response by Mann, Ma

“…Background: The pathophysiology of bipolar disorder (BD) remains largely unknown despite it causing significant disability and suicide risk. Serotonin…”
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antaRNA--Multi-objective inverse folding of pseudoknot RNA using ant-colony optimization by Kleinkauf, Robert, Houwaart, Torsten, Backofen, Rolf, Mann, Martin

“…Many functional RNA molecules fold into pseudoknot structures, which are often essential for the formation of an RNA's 3D structure. Currently the design of…”
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CPSP-tools--exact and complete algorithms for high-throughput 3D lattice protein studies by Mann, Martin, Will, Sebastian, Backofen, Rolf

“…The principles of protein folding and evolution pose problems of very high inherent complexity. Often these problems are tackled using simplified protein…”
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Neuregulins Increase alpha 7 Nicotinic Acetylcholine Receptors and Enhance Excitatory Synaptic Transmission in GABAergic Interneurons of the Hippocampus by Liu, Y, d, B, Mann, MA, Fischbach, G D

“…Neuregulins are highly expressed in the CNS, especially in cholinergic neurons. We have examined the effect of neuregulin on nicotinic acetylcholine receptors…”
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Atom mapping with constraint programming by Mann, Martin, Nahar, Feras, Schnorr, Norah, Backofen, Rolf, Stadler, Peter F, Flamm, Christoph

“…Chemical reactions are rearrangements of chemical bonds. Each atom in an educt molecule thus appears again in a specific position of one of the reaction…”
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Pathological assessments for the presence of hexanucleotide repeat expansions in C9ORF72 in Alzheimer's disease by Davidson, Yvonne S, Robinson, Andrew C, Snowden, Julie S, Mann, David M A

“…We have sought histological evidence, using TDP-43 and p62 immunohistochemistry, for the presence of expansions in C9ORF72 among 200 patients with…”
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Frontotemporal lobar degeneration: Pathogenesis, pathology and pathways to phenotype by Mann, David M.A., Snowden, Julie S.

“…Frontotemporal Lobar Degeneration (FTLD) is a clinically, pathologically and genetically heterogeneous group of disorders that affect principally the frontal…”
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Magnetite pollution nanoparticles in the human brain by Maher, Barbara A., Ahmed, Imad A. M., Karloukovski, Vassil, MacLaren, Donald A., Foulds, Penelope G., Allsop, David, Mann, David M. A., Torres-Jardón, Ricardo, Calderon-Garciduenas, Lilian

“…Biologically formed nanoparticles of the strongly magnetic mineral, magnetite, were first detected in the human brain over 20 y ago [Kirschvink JL,…”
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Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau by Taniguchi-Watanabe, Sayuri, Arai, Tetsuaki, Kametani, Fuyuki, Nonaka, Takashi, Masuda-Suzukake, Masami, Tarutani, Airi, Murayama, Shigeo, Saito, Yuko, Arima, Kunimasa, Yoshida, Mari, Akiyama, Haruhiko, Robinson, Andrew, Mann, David M. A., Iwatsubo, Takeshi, Hasegawa, Masato

“…Intracellular filamentous tau pathology is the defining feature of tauopathies, which form a subset of neurodegenerative diseases. We have analyzed…”
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Neuregulin-1 increases the proliferation of neuronal progenitors from embryonic neural stem cells by Liu, Yun, Ford, Byron D., Mann, Mary Anne, Fischbach, Gerald D.

“…Neuregulins are a family of proteins expressed in the developing brain and in brain regions that continue to undergo neurogenesis in adult animals. We…”
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Classification and pathology of primary progressive aphasia by Harris, Jennifer M, Gall, Claire, Thompson, Jennifer C, Richardson, Anna M.T, Neary, David, du Plessis, Daniel, Pal, Piyali, Mann, David M.A, Snowden, Julie S, Jones, Matthew

“…OBJECTIVE:We aimed to determine the extent to which patients with progressive language impairment conform to 2011 primary progressive aphasia (PPA)…”
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Examining the language and behavioural profile in FTD and ALS-FTD by Saxon, Jennifer A, Thompson, Jennifer C, Jones, Matthew, Harris, Jennifer M, Richardson, Anna MT, Langheinrich, Tobias, Neary, David, Mann, David MA, Snowden, Julie S

“…BackgroundA proportion of patients with behavioural variant frontotemporal dementia (bvFTD) develop amyotrophic lateral sclerosis (ALS). It is currently…”
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The clinical diagnosis of early-onset dementias: diagnostic accuracy and clinicopathological relationships by Snowden, Julie S., Thompson, Jennifer C., Stopford, Cheryl L., Richardson, Anna M. T., Gerhard, Alex, Neary, David, Mann, David M. A.

“…Accuracy of clinical diagnosis of dementia is increasingly important for therapeutic and scientific investigations. In this study, we examine diagnostic…”
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Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update by Mackenzie, Ian R. A., Neumann, Manuela, Bigio, Eileen H., Cairns, Nigel J., Alafuzoff, Irina, Kril, Jillian, Kovacs, Gabor G., Ghetti, Bernardino, Halliday, Glenda, Holm, Ida E., Ince, Paul G., Kamphorst, Wouter, Revesz, Tamas, Rozemuller, Annemieke J. M., Kumar-Singh, Samir, Akiyama, Haruhiko, Baborie, Atik, Spina, Salvatore, Dickson, Dennis W., Trojanowski, John Q., Mann, David M. A.

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Increased TDP-43 protein in cerebrospinal fluid of patients with amyotrophic lateral sclerosis by Kasai, Takashi, Tokuda, Takahiko, Ishigami, Noriko, Sasayama, Hiroshi, Foulds, Penelope, Mitchell, Douglas J., Mann, David M. A., Allsop, David, Nakagawa, Masanori

“…There is mounting pathological, biochemical and genetic evidence that the metabolism and aggregation of the 43-kDa transactive response (TAR)-DNA-binding…”
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Detection of elevated levels of soluble α-synuclein oligomers in post-mortem brain extracts from patients with dementia with Lewy bodies by Paleologou, Katerina E., Kragh, Christine L., Mann, David M. A., Salem, Sultan A., Al-Shami, Rania, Allsop, David, Hassan, Ahmed H., Jensen, Poul H., El-Agnaf, Omar M. A.

“…A number of neurodegenerative diseases including Parkinson's disease, dementia with Lewy bodies (DLB) and multiple system atrophy are characterized by the…”
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Nomenclature for neuropathologic subtypes of frontotemporal lobar degeneration: consensus recommendations by Mackenzie, Ian R. A., Neumann, Manuela, Bigio, Eileen H., Cairns, Nigel J., Alafuzoff, Irina, Kril, Jillian, Kovacs, Gabor G., Ghetti, Bernardino, Halliday, Glenda, Holm, Ida E., Ince, Paul G., Kamphorst, Wouter, Revesz, Tamas, Rozemuller, Annemieke J. M., Kumar-Singh, Samir, Akiyama, Haruhiko, Baborie, Atik, Spina, Salvatore, Dickson, Dennis W., Trojanowski, John Q., Mann, David M. A.

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Dipeptide repeat proteins are present in the p62 positive inclusions in patients with frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9ORF72 by Mann, David M A, Rollinson, Sara, Robinson, Andrew, Bennion Callister, Janis, Thompson, Jennifer C, Snowden, Julie S, Gendron, Tania, Petrucelli, Leonard, Masuda-Suzukake, Masami, Hasegawa, Masato, Davidson, Yvonne, Pickering-Brown, Stuart

“…Cases of Frontotemporal Lobar Degeneration (FTLD) and Motor Neurone Disease (MND) associated with expansions in C9ORF72 gene are characterised pathologically…”
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TDP-43 pathological changes in early onset familial and sporadic Alzheimer’s disease, late onset Alzheimer’s disease and Down’s Syndrome: association with age, hippocampal sclerosis and clinical phenotype by Davidson, Yvonne S., Raby, Samantha, Foulds, Penelope G., Robinson, Andrew, Thompson, Jennifer C., Sikkink, Stephen, Yusuf, Imran, Amin, Hanan, DuPlessis, Daniel, Troakes, Claire, Al-Sarraj, Safa, Sloan, Carolyn, Esiri, Margaret M., Prasher, Vee P., Allsop, David, Neary, David, Pickering-Brown, Stuart M., Snowden, Julie S., Mann, David M. A.

“…TDP-43 immunoreactive (TDP-43-ir) pathological changes were investigated in the temporal cortex and hippocampus of 11 patients with autosomal dominant familial…”
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Molecular analysis and biochemical classification of TDP-43 proteinopathy by TSUJI, Hiroshi, ARAI, Tetsuaki, SAITO, Yuko, MURAYAMA, Shigeo, AKIYAMA, Haruhiko, HASEGAWA, Masato, MANN, David M. A, TAMAOKA, Akira, KAMETANI, Fuyuki, NONAKA, Takashi, YAMASHITA, Makiko, SUZUKAKE, Masami, HOSOKAWA, Masato, YOSHIDA, Mari, HATSUTA, Hiroyuki, TAKAO, Masaki

“…Amyotrophic lateral sclerosis and frontotemporal lobar degeneration with TAR DNA-binding protein of 43 kDa pathology are progressive neurodegenerative diseases…”
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