Search Results - "Mann, K P"

Insights into Nano- and Micron-Scale Phase Separation in Amorphous Solid Dispersions Using Fluorescence-Based Techniques in Combination with Solid State Nuclear Magnetic Resonance Spectroscopy by Purohit, Hitesh S., Ormes, James D., Saboo, Sugandha, Su, Yongchao, Lamm, Matthew S., Mann, Amanda K. P., Taylor, Lynne S.

“…Purpose Miscibility between the drug and the polymer in an amorphous solid dispersion (ASD) is considered to be one of the most important factors impacting the…”
Get full text

Spectroscopic Investigation of Surface-Dependent Acid–Base Property of Ceria Nanoshapes by Wu, Zili, Mann, Amanda K. P, Li, Meijun, Overbury, Steven H

“…In addition to their well-known redox character, the acid–base property is another interesting aspect of ceria-based catalysts. Herein, the effect of surface…”
Get full text

Adsorption and Reaction of Acetaldehyde on Shape-Controlled CeO2 Nanocrystals: Elucidation of Structure–Function Relationships by Mann, Amanda K. P, Wu, Zili, Calaza, Florencia C, Overbury, Steven H

“…CeO2 cubes with {100} facets, octahedra with {111} facets, and wires with highly defective structures were utilized to probe the structure-dependent reactivity…”
Get full text

Processing Impact on In Vitro and In Vivo Performance of Solid Dispersions—A Comparison between Hot-Melt Extrusion and Spray Drying by Li, Yongjun, Mann, Amanda K. P., Zhang, Dan, Yang, Zhen

“…Presently, a large number of drug molecules in development are BCS class II or IV compounds with poor aqueous solubility. Various novel solubilization…”
Get full text

Synthesis of Single-Crystalline Nanoplates by Spray Pyrolysis: A Metathesis Route to Bi2WO6 by Mann, Amanda K. P, Skrabalak, Sara E

“…Here, a solid-state metathesis reaction has been coupled with ultrasonic spray pyrolysis (USP) for the first time, yielding single-crystalline Bi2WO6…”
Get full text

Drug Release and Nanodroplet Formation from Amorphous Solid Dispersions: Insight into the Roles of Drug Physicochemical Properties and Polymer Selection by Yang, Ruochen, Mann, Amanda K. P, Van Duong, Tu, Ormes, James D, Okoh, Grace A, Hermans, Andre, Taylor, Lynne S

“…Dissolution of amorphous solid dispersions (ASD) can lead to the formation of amorphous drug-rich nano species (nanodroplets) via liquid–liquid phase…”
Get full text

Impact of Endogenous Bile Salts on the Thermodynamics of Supersaturated Active Pharmaceutical Ingredient Solutions by Lu, Jennifer, Ormes, James D, Lowinger, Michael, Xu, Wei, Mitra, Amitava, Mann, Amanda K. P, Litster, James D, Taylor, Lynne S

“…A variety of formulation strategies have been developed to mitigate the inadequate aqueous solubility of certain therapeutic agents. Among these, achieving…”
Get full text

What is clinically relevant prolapse? An attempt at defining cutoffs for the clinical assessment of pelvic organ descent by Dietz, H. P., Mann, K. P.

“…Introduction and hypothesis This study was undertaken to investigate the relationship between symptoms of prolapse and International Continence Society Pelvic…”
Get full text

Sub 2‑μm Macroporous Silica Particles Derivatized for Enhanced Lectin Affinity Enrichment of Glycoproteins by Mann, Benjamin F, Mann, Amanda K. P, Skrabalak, Sara E, Novotny, Milos V

“…A new, mechanically stable silica microparticle with macrosized internal pores (1.6 μm particles with 100 nm pores) has been developed for chromatography. The…”
Get full text

Fast MAS 1H NMR Study of Water Adsorption and Dissociation on the (100) Surface of Ceria Nanocubes: A Fully Hydroxylated, Hydrophobic Ceria Surface by Gill, Lance, Beste, Ariana, Chen, Banghao, Li, Meijun, Mann, Amanda K. P, Overbury, Steven H, Hagaman, Edward W

“…1H nuclear magnetic resonance (NMR) spectroscopy was used to study hydroxylic surface species on ceria nanocubes, a crystalline, high-surface-area CeO2 that…”
Get full text

Long-term progression-free survival after early autologous transplantation for mantle-cell lymphoma by Murali, S, Winton, E, Waller, E K, Heffner, L T, Lonial, S, Flowers, C, Kaufman, J, Arellano, M, Lechowicz, M J, Mann, K P, Khoury, H J, Langston, A A

“…Autologous hematopoietic progenitor SCT (HPCT) has been studied both as a consolidative and salvage maneuver in mantle-cell lymphoma (MCL), and may improve…”
Get full text

Thiolate Ligands as a Double-Edged Sword for CO Oxidation on CeO2 Supported Au25(SCH2CH2Ph)18 Nanoclusters by Wu, Zili, Jiang, De-en, Mann, Amanda K. P, Mullins, David R, Qiao, Zhen-An, Allard, Lawrence F, Zeng, Chenjie, Jin, Rongchao, Overbury, Steven H

“…The effect of thiolate ligands was explored on the catalysis of CeO2 rod supported Au25(SR)18 (SR = −SCH2CH2Ph) by using CO oxidation as a probe reaction…”
Get full text

Correlation of extended RAS and PIK3CA gene mutation status with outcomes from the phase III AGITG MAX STUDY involving capecitabine alone or in combination with bevacizumab plus or minus mitomycin C in advanced colorectal cancer by Price, T J, Bruhn, M A, Lee, C K, Hardingham, J E, Townsend, A R, Mann, K P, Simes, J, Weickhardt, A, Wrin, J W, Wilson, K, Gebski, V, Van Hazel, G, Robinson, B, Cunningham, D, Tebbutt, N C

“…Background: Mutations affecting RAS genes are now established predictive markers of nonresponse to anti-EGFR antibodies in advanced CRC. This analysis assessed…”
Get full text

Molecular impact of selective NFKB1 and NFKB2 signaling on DLBCL phenotype by Guo, X, Koff, J L, Moffitt, A B, Cinar, M, Ramachandiran, S, Chen, Z, Switchenko, J M, Mosunjac, M, Neill, S G, Mann, K P, Bagirov, M, Du, Y, Natkunam, Y, Khoury, H J, Rossi, M R, Harris, W, Flowers, C R, Lossos, I S, Boise, L H, Dave, S S, Kowalski, J, Bernal-Mizrachi, L

“…Diffuse large B-cell lymphoma (DLBCL) has been categorized into two molecular subtypes that have prognostic significance, namely germinal center B-cell like…”
Get full text

Neutrophil-rich, Ki-1-positive anaplastic large-cell malignant lymphoma by Mann, K P, Hall, B, Kamino, H, Borowitz, M J, Ratech, H

“…The presence of neutrophils, in the absence of necrosis, is uncommon in malignant lymphoma (ML). We identified a subgroup of Ki-1-positive anaplastic large…”
Get more information

CD56 Expression in Acute Promyelocytic Leukemia: A Possible Indicator of Poor Treatment Outcome? by MURRAY, C. K, ESTEY, E, PAIETTA, E, HOWARD, R. S, EDENFIELD, W. J, PIERCE, S, MANN, K. P, BOLAN, C, BYRD, J. C

“…Blast expression of CD56 is frequent in patients with t(8;21)(q22;q22) acute myeloid leukemia and is associated with an inferior outcome. The expression of…”
Get full text

Rising cost of anticancer drugs in Australia by Karikios, D. J., Schofield, D., Salkeld, G., Mann, K. P., Trotman, J., Stockler, M. R.

“…Background Anticancer drugs are often expensive and are contributing to the growing cost of cancer care. Concerns have been raised about the effect rising…”
Get full text

Building a better particle: Leveraging physicochemical understanding of amorphous solid dispersions and a hierarchical particle approach for improved delivery at high drug loadings by Schenck, Luke, Mann, Amanda K.P., Liu, Zhen, Milewski, Mikolaj, Zhang, Siwei, Ren, Jie, Dewitt, Kristel, Hermans, Andre, Cote, Aaron

“…[Display omitted] Amorphous solid dispersions are a promising option for managing compounds with poor aqueous solubility. However, for compounds with high…”
Get full text

Epstein-Barr virus-encoded protein found in plasma membranes of transformed cells by Mann, K P, Staunton, D, Thorley-Lawson, D A

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Producing Amorphous Solid Dispersions via Co-Precipitation and Spray Drying: Impact to Physicochemical and Biopharmaceutical Properties by Mann, Amanda K P, Schenck, Luke, Koynov, Athanas, Rumondor, Alfred C F, Jin, Xiaoling, Marota, Melanie, Dalton, Chad

“…Many small-molecule active pharmaceutical ingredients (APIs) exhibit low aqueous solubility and benefit from generation of amorphous dispersions of the API and…”
Get more information