Search Results - "Manlove, Luke S."

Quantifying Memory CD8 T Cells Reveals Regionalization of Immunosurveillance by Steinert, Elizabeth M., Schenkel, Jason M., Fraser, Kathryn A., Beura, Lalit K., Manlove, Luke S., Igyártó, Botond Z., Southern, Peter J., Masopust, David

“…Memory CD8 T cells protect against intracellular pathogens by scanning host cell surfaces; thus, infection detection rates depend on memory cell number and…”
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Virus-specific memory T cells populate tumors and can be repurposed for tumor immunotherapy by Rosato, Pamela C., Wijeyesinghe, Sathi, Stolley, J. Michael, Nelson, Christine E., Davis, Rachel L., Manlove, Luke S., Pennell, Christopher A., Blazar, Bruce R., Chen, Clark C., Geller, Melissa A., Vezys, Vaiva, Masopust, David

“…The immunosuppressive tumor microenvironment limits the success of current immunotherapies. The host retains memory T cells specific for previous infections…”
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TALEN-engineered AR gene rearrangements reveal endocrine uncoupling of androgen receptor in prostate cancer by Nyquist, Michael D., Li, Yingming, Hwang, Tae Hyun, Manlove, Luke S., Vessella, Robert L., Silverstein, Kevin A. T., Voytas, Daniel F., Dehm, Scott M.

“…Androgen receptor (AR) target genes direct development and survival of the prostate epithelial lineage, including prostate cancer (PCa). Thus, endocrine…”
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Modular assembly of transposon integratable multigene vectors using RecWay assembly by Moriarity, Branden S, Rahrmann, Eric P, Keng, Vincent W, Manlove, Luke S, Beckmann, Dominic A, Wolf, Natalie K, Khurshid, Touba, Bell, Jason B, Largaespada, David A

“…Studying complex biological processes such as cancer development, stem cell induction and transdifferentiation requires the modulation of multiple genes or…”
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Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells by Mahmud, Shawn A, Manlove, Luke S, Schmitz, Heather M, Xing, Yan, Wang, Yanyan, Owen, David L, Schenkel, Jason M, Boomer, Jonathan S, Green, Jonathan M, Yagita, Hideo, Chi, Hongbo, Hogquist, Kristin A, Farrar, Michael A

“…The precise mechanisms of the thymic development T reg cells are still being determined. Farrar and colleagues demonstrate that signals from a triumvirate of…”
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Adaptive Immunity to Leukemia Is Inhibited by Cross-Reactive Induced Regulatory T Cells by Manlove, Luke S, Berquam-Vrieze, Katherine E, Pauken, Kristen E, Williams, Richard T, Jenkins, Marc K, Farrar, Michael A

“…BCR-ABL(+) acute lymphoblastic leukemia patients have transient responses to current therapies. However, the fusion of BCR to ABL generates a potential…”
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Heterologous Vaccination and Checkpoint Blockade Synergize To Induce Antileukemia Immunity by Manlove, Luke S, Schenkel, Jason M, Manlove, Kezia R, Pauken, Kristen E, Williams, Richard T, Vezys, Vaiva, Farrar, Michael A

“…Checkpoint blockade-based immunotherapies are effective in cancers with high numbers of nonsynonymous mutations. In contrast, current paradigms suggest that…”
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Interleukin-2 and STAT5 in regulatory T cell development and function by Mahmud, Shawn A., Manlove, Luke S., Farrar, Michael A.

“…Interleukin-2 and its downstream target STAT5 have effects on many aspects of immune function. This has been perhaps best documented in regulatory T cells. In…”
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Abstract 1789: CD30+T regulatory cells, but not CD30+CD8 T cells, are impaired following brentuximab vedotin treatment in vitro and in vivo by Heiser, Ryan A., Grogan, Bryan M., Manlove, Luke S., Gardai, Shyra J.

“…Abstract Brentuximab vedotin (BV) is an antibody-drug conjugate (ADC) directed against CD30, a TNF receptor superfamily (TNFRSF) member highly expressed on…”
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Overcoming Leukemia-Induced Immune Suppression in BCR-ABL+ Acute Lymphoblastic Leukemia by Farrar, Michael, Hekim, Can, Luke, Manlove S., Vezys, Vaiva, Jenkins, Marc K

“…BCR-ABL+ acute lymphoblastic leukemia patients have transient responses to current therapies. However, the fusion of BCR to ABL generates a potential…”
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Virus-specific memory T cells populate tumors and can be repurposed as a tumor immunotherapy by Rosato, Pamela, Wijeyesinghe, Sathi, Stolley, Michael, Nelson, Christine, Davis, Rachel L, Manlove, Luke S, Pennell, Christopher A, Blazar, Bruce R., Chen, Clark C, Geller, Melissa A, Vezys, Vaiva, Masopust, David

“…Abstract The immunosuppressive tumor microenvironment limits the success of current immunotherapies. The host retains memory T cells specific for previous…”
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Heterologous vaccination and checkpoint blockade synergize to induce anti-leukemia immunity by Manlove, Luke S., Schenkel, Jason M., Manlove, Kezia R., Pauken, Kristen E., Williams, Richard T., Vezys, Vaiva, Farrar, Michael A.

“…Checkpoint blockade-based immunotherapies are effective in cancers with high numbers of non-synonymous mutations. In contrast, current paradigms suggest that…”
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Tumor necrosis factor receptor superfamily costimulation couples T cell receptor signal strength to thymic regulatory T cell differentiation by Mahmud, Shawn A., Manlove, Luke S., Schmitz, Heather M., Xing, Yan, Wang, Yanyan, Owen, David L., Schenkel, Jason M., Boomer, Jonathan S., Green, Jonathan M., Yagita, Hideo, Chi, Hongbo, Hogquist, Kristin A., Farrar, Michael A.

“…Regulatory T (T reg ) cells express tumor necrosis factor receptor superfamily (TNFRSF) members, but their role in thymic T reg development is undefined. We…”
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