Search Results - "Mankovich, John A."

Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design by Dietrich, Justin D, Longenecker, Kenton L, Wilson, Noel S, Goess, Christian, Panchal, Sanjay C, Swann, Steven L, Petros, Andrew M, Hobson, Adrian D, Ihle, David, Song, Danying, Richardson, Paul, Comess, Kenneth M, Cox, Philip B, Dombrowski, Amanda, Sarris, Kathy, Donnelly-Roberts, Diana L, Duignan, David B, Gomtsyan, Arthur, Jung, Paul, Krueger, A Chris, Mathieu, Suzanne, McClure, Andrea, Stoll, Vincent S, Wetter, Jill, Mankovich, John A, Hajduk, Philip J, Vasudevan, Anil, Stoffel, Robert H, Sun, Chaohong

“…Tumor necrosis factor α (TNFα) is a soluble cytokine that is directly involved in systemic inflammation through the regulation of the intracellular NF-κB and…”
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Substrate Specificities of Caspase Family Proteases by Talanian, R V, Quinlan, C, Trautz, S, Hackett, M C, Mankovich, J A, Banach, D, Ghayur, T, Brady, K D, Wong, W W

“…The caspase family represents a new class of intracellular cysteine proteases with known or suspected roles in cytokine maturation and apoptosis. These enzymes…”
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2,4-Diaminopyrimidine MK2 inhibitors. Part I: Observation of an unexpected inhibitor binding mode by Argiriadi, Maria A., Ericsson, Anna M., Harris, Christopher M., Banach, David L., Borhani, David W., Calderwood, David J., Demers, Megan D., DiMauro, Jennifer, Dixon, Richard W., Hardman, Jennifer, Kwak, Silvia, Li, Biqin, Mankovich, John A., Marcotte, Douglas, Mullen, Kelly D., Ni, Baofu, Pietras, M., Sadhukhan, Ramkrishna, Sousa, Silvino, Tomlinson, Medha J., Wang, Lu, Xiang, Tao, Talanian, Robert V.

“…MK2 is a Ser/Thr kinase of significant interest as an anti-inflammatory drug discovery target. Here we describe the development of in vitro tools for the…”
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Functional comparison of recombinant acidic mammalian chitinase with enzyme from murine bronchoalveolar lavage by Goedken, Eric R., O’Brien, Robert F., Xiang, Tao, Banach, David L., Marchie, Susan C., Barlow, Eve H., Hubbard, Stacy, Mankovich, John A., Jiang, Jianjun, Richardson, Paul L., Cuff, Carolyn A., Cherniack, Andrew D.

“…Acidic mammalian chitinase (AMCase) is an enzyme that selectively degrades the biopolymer chitin. Several chitinase enzymes are utilized by mammals to…”
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Regulation of Protein Phosphatase 2A Activity by Caspase-3 during Apoptosis by Santoro, Maxine F., Annand, Robert R., Robertson, Molly M., Peng, Yun-Wen, Brady, Matthew J., Mankovich, John A., Hackett, Maria C., Ghayur, Tariq, Walter, Gernot, Wong, Winnie W., Giegel, David A.

“…Although the available evidence suggests that whereas the caspase family plays a major role in apoptosis, they are not the sole stimulators of death. A random…”
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Protease Activity of in Vitro Transcribed and Translated Caenorhabditis elegans Cell Death Gene (ced-3) Product (∗) by Hugunin, Margaret, Quintal, Lucia J., Mankovich, John A., Ghayur, Tariq

“…The Caenorhabditis elegans cell death gene, ced-3, encodes one of the two proteins required for apoptosis in this organism. The primary sequence similarities…”
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Preparation of an Autolysis-Resistant Interleukin-1β Converting Enzyme Mutant by Dang, Luan C, Talanian, Robert V, Banach, David, Hackett, Maria C, Gilmore, John L, Hays, Sheryl J, Mankovich, John A, Brady, Kenneth D

“…We describe the expression, purification, and characterization of human interleukin-1β converting enzyme (ICE) containing an affinity tag and modified to…”
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Identification and Characterization of ICH-2, a Novel Member of the Interleukin-1β-converting Enzyme Family of Cysteine Proteases (∗) by Kamens, Joanne, Paskind, Michael, Hugunin, Margaret, Talanian, Robert V., Allen, Hamish, Banach, David, Bump, Nancy, Hackett, Maria, Johnston, Cynthia G., Li, Ping, Mankovich, John A., Terranova, Michele, Ghayur, Tariq

“…Interleukin-1β converting enzyme (ICE) is a cytoplasmic cysteine protease required for generating the bioactive form of the interleukin-1β cytokine from its…”
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Caspase-1 (interleukin-1beta-converting enzyme) is inhibited by the human serpin analogue proteinase inhibitor 9 by Annand, R R, Dahlen, J R, Sprecher, C A, De Dreu, P, Foster, D C, Mankovich, J A, Talanian, R V, Kisiel, W, Giegel, D A

“…The regulation of caspases, cysteine proteinases that cleave their substrates after aspartic residues, is poorly understood, even though they are involved in…”
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Caspase-1 (interleukin-1β-converting enzyme) is inhibited by the human serpin analogue proteinase inhibitor 9 by ANNAND, Robert R., DAHLEN, Jeffrey R., SPRECHER, Cindy A., DREU, Piet DE, FOSTER, Donald C., MANKOVICH, John A., TALANIAN, Robert V., KISIEL, Walter, GIEGEL, David A.

“…The regulation of caspases, cysteine proteinases that cleave their substrates after aspartic residues, is poorly understood, even though they are involved in…”
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Stability and Oligomeric Equilibria of Refolded Interleukin-1β Converting Enzyme by Talanian, Robert V., Dang, Luan C., Ferenz, Catherine R., Hackett, Maria C., Mankovich, John A., Welch, Jeffrey P., Wong, Winnie W., Brady, Kenneth D.

“…We report the preparation and characterization of interleukin-1 beta converting enzyme (ICE) refolded from its p20 and p10 protein fragments. Refolded ICE…”
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Stability and Oligomeric Equilibria of Refolded Interleukin-1β Converting Enzyme by Robert V. Talanian, Luan C. Dang, Catherine R. Ferenz, Maria C. Hackett, John A. Mankovich, Jeffrey P. Welch, Winnie W. Wong, Kenneth D. Brady

“…We report the preparation and characterization of interleukin-1β converting enzyme (ICE) refolded from its p20 and p10 protein fragments. Refolded ICE…”
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Stability and oligomeric equilibria of refolded interleukin-1β converting enzyme by Talanian, Robert V., Dang, Luan C., Ferenz, Catherine R., Hackett, Maria C., Mankovich, John A., Welch, Jeffrey P., Wong, Winnie W., Brady, Kenneth D.

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Identification and Characterization of ICH-2, a Novel Member of the Interleukin-1-converting Enzyme Family of Cysteine Proteases by Joanne Kamens, Michael Paskind, Margaret Hugunin, Robert V. Talanian, Hamish Allen, David Banach, Nancy Bump, Maria Hackett, Cynthia G. Johnston, Ping Li, John A. Mankovich, Michele Terranova, Tariq Ghayur

“…Interleukin-1β converting enzyme (ICE) is a cytoplasmic cysteine protease required for generating the bioactive form of the interleukin-1β cytokine from its…”
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