Search Results - "Mankan, Arun K"

Cytosolic RNA:DNA hybrids activate the cGAS-STING axis by Mankan, Arun K, Schmidt, Tobias, Chauhan, Dhruv, Goldeck, Marion, Höning, Klara, Gaidt, Moritz, Kubarenko, Andrew V, Andreeva, Liudmila, Hopfner, Karl-Peter, Hornung, Veit

“…Intracellular recognition of non‐self and also self‐nucleic acids can result in the initiation of potent pro‐inflammatory and antiviral cytokine responses…”
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Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis by Ziegler, Paul K., Bollrath, Julia, Pallangyo, Charles K., Matsutani, Takaji, Canli, Özge, De Oliveira, Tiago, Diamanti, Michaela A., Müller, Nina, Gamrekelashvili, Jaba, Putoczki, Tracy, Horst, David, Mankan, Arun K., Öner, Meryem G., Müller, Susanna, Müller-Höcker, Josef, Kirchner, Thomas, Slotta-Huspenina, Julia, Taketo, M. Mark, Reinheckel, Thomas, Dröse, Stefan, Larner, Andrew C., Wels, Winfried S., Ernst, Matthias, Greten, Tim F., Arkan, Melek C., Korn, Thomas, Wirth, Dagmar, Greten, Florian R.

“…In colorectal cancer patients, a high density of cytotoxic CD8+ T cells in tumors is associated with better prognosis. Using a Stat3 loss-of-function approach…”
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Intracellular DNA sensing by neutrophils and amplification of the innate immune response by Mankan, Arun K, Czajka-Francuz, Paulina, Prendes, Maria, Ramanan, Sriram, Koziej, Marcin, Vidal, Laura, Saini, Kamal S

“…As the first responders, neutrophils lead the innate immune response to infectious pathogens and inflammation inducing agents. The well-established pathogen…”
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Inhibiting signal transducer and activator of transcription 3: rationality and rationale design of inhibitors by Mankan, Arun K, Greten, Florian R

“…Signal transducer and activator of transcription 3 (STAT3) controls a key signaling pathway in the development of many malignant diseases. Several genetic…”
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Retroviral Danger from Within: TLR7 Is in Control by Mankan, Arun K., Hornung, Veit

“…In this issue of Immunity, Yu et al. (2012) outline a fascinating model in which TLR7-mediated antibody production acts as a dominant immunosurveillance…”
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TNF-α-dependent loss of IKKβ-deficient myeloid progenitors triggers a cytokine loop culminating in granulocytosis by Mankan, Arun K., Canli, Ozge, Schwitalla, Sarah, Ziegler, Paul, Tschopp, Jurg, Korn, Thomas, Greten, Florian R., Karin, Michael

“…Loss of 1κB kinase (IKK) β-dependent NF-κB signaling in hematopoietic cells is associated with increased granulopoiesis. Here we identify a regulatory cytokine…”
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Cancer Trials Ecosystem in India-Ready for Prime Time? by Mankan, Arun K, Shankar, Abhishek, Limaye, Sewanti, Ajaikumar, B S, Nachane, Prajakta, Singh, Navneet, Dawkhar, Shekhar, Batra, Ullas, Bhosekar, Amol, Ganguly, Sandip, Gawli, Pramod, Debnath, Khokan, Padalalu, Vivek, Reddy, Prasanth, Sundaramoorthy, Shanthi, Naveen, K K, Bondarde, Shailesh, Kumar, Praveen, Davis, Sanish, Ramkissoon, Shakti H, Chacko, Raju Titus, Vidal, Laura, Chico, Isagani, Hegedus, Andrew, Gupta, Sudeep, Saini, Kamal S

“…Executing global clinical trials for cancer is a long, expensive, and complex undertaking. While selecting countries global studies, sponsors must consider…”
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IKKα Promotes Intestinal Tumorigenesis by Limiting Recruitment of M1-like Polarized Myeloid Cells by Göktuna, Serkan I., Canli, Ozge, Bollrath, Julia, Fingerle, Alexander A., Horst, David, Diamanti, Michaela A., Pallangyo, Charles, Bennecke, Moritz, Nebelsiek, Tim, Mankan, Arun K., Lang, Roland, Artis, David, Hu, Yinling, Patzelt, Thomas, Ruland, Jürgen, Kirchner, Thomas, Taketo, M. Mark, Chariot, Alain, Arkan, Melek C., Greten, Florian R.

“…The recruitment of immune cells into solid tumors is an essential prerequisite of tumor development. Depending on the prevailing polarization profile of these…”
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The NLRP3/ASC/Caspase‐1 axis regulates IL‐1β processing in neutrophils by Mankan, Arun K., Dau, Therese, Jenne, Dieter, Hornung, Veit

“…Neutrophils play a pivotal role in the defense against bacterial, viral and fungal infections and are important mediators in the acute inflammatory response…”
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Expression of hereditary hemochromatosis C282Y HFE protein in HEK293 cells activates specific endoplasmic reticulum stress responses by Lawless, Matthew W, Mankan, Arun K, White, Mary, O'Dwyer, Michael J, Norris, Suzanne

“…Hereditary Hemochromatosis (HH) is a genetic disease associated with iron overload, in which individuals homozygous for the mutant C282Y HFE associated allele…”
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Sox2 as a servant of two masters by Mankan, Arun K, Hornung, Veit

“…The transcription factor Sox2 has an additional function in neutrophils, as a cytoplasmic sensor of DNA. Upon binding bacterial DNA, Sox2 initiates a signaling…”
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NF‐κB regulation: the nuclear response by Mankan, Arun K., Lawless, Matthew W., Gray, Steven G., Kelleher, Dermot, McManus, Ross

“…•  Introduction •  Activation of NF‐κB •  Regulators of NF‐κB activation •  Nuclear regulation of NF‐κB ‐  B cell lymphoma 3 (Bcl‐3) ‐  IκB‐ζ ‐  UXT, ZAS3 and…”
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Bladder Cancer, Loss of Y Chromosome, and New Opportunities for Immunotherapy by Mankan, Arun K., Mankan, Nagender, de las Heras, Begona, Ramkissoon, Shakti H., Bodriagova, Olga, Vidal, Laura, Grande, Enrique, Saini, Kamal S.

“…Immune checkpoint inhibitors (ICI) have emerged as an important therapeutic approach for patients with cancers including bladder cancer (BC). This commentary…”
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IKKα Promotes Intestinal Tumorigenesis by Limiting Recruitment of M1-like Polarized Myeloid Cells by Göktuna, Serkan I., Canli, Ozge, Bollrath, Julia, Fingerle, Alexander A., Horst, David, Diamanti, Michaela A., Pallangyo, Charles, Bennecke, Moritz, Nebelsiek, Tim, Mankan, Arun K., Lang, Roland, Artis, David, Hu, Yinling, Patzelt, Thomas, Ruland, Jürgen, Kirchner, Thomas, Taketo, M. Mark, Chariot, Alain, Arkan, Melek C., Greten, Florian R.

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Cyclic Dinucleotides in the Scope of the Mammalian Immune System by Mankan, Arun K, Müller, Martina, Witte, Gregor, Hornung, Veit

“…First discovered in prokaryotes and more recently in eukaryotes, cyclic dinucleotides (CDNs) constitute a unique branch of second messenger signaling systems…”
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The occurrence of severe sepsis and septic shock are related to distinct patterns of cytokine gene expression by O'Dwyer, Michael J, Mankan, Arun K, Stordeur, Patrick, O'Connell, Brian, Duggan, Edel, White, Mary, Kelleher, Dermot P, McManus, Ross, Ryan, Thomas

“…Patient response to acute bacterial infection is highly variable. Differing outcomes in this setting may be related to variations in the immune response to an…”
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The human response to infection is associated with distinct patterns of interleukin 23 and interleukin 27 expression by O’Dwyer, Michael J., Mankan, Arun K., White, Mary, Lawless, Mathew W., Stordeur, Patrick, O’Connell, Brian, Kelleher, Dermot P., McManus, Ross, Ryan, Thomas

“…Objective The development and progression of severe sepsis is related to a deficiency in pro-inflammatory cytokine production, characterised by lesser IFNγ…”
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Endoplasmic reticulum stress—A double edged sword for Z alpha-1 antitrypsin deficiency hepatoxicity by Lawless, Matthew W., Mankan, Arun K., Gray, Steven G., Norris, Suzanne

“…Several diverse disorders, including the liver disorder Z alpha-1 antitrypsin deficiency as well as cystic fibrosis, Alzheimer's, and Parkinson's disease arise…”
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Tauroursodeoxycholic acid: Relieving the pathogenesis of HFE C282Y hereditary hemochromatosis by Lawless, Matthew W., Mankan, Arun K., Ryan, Anthony W., Norris, Suzanne

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Hereditary hemochromatosis should be considered a conformational disorder by Lawless, Matthew W, Mankan, Arun K, Norris, Suzanne

“…Summary Hereditary hemochromatosis (HH) is a genetic disease associated with iron overload, in which individuals homozygous for the mutant C282Y HFE associated…”
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