Search Results - "Manjunath, Kavyashree"

COVID-19 pandemic: Insights into structure, function, and hACE2 receptor recognition by SARS-CoV-2 by Mittal, Anshumali, Manjunath, Kavyashree, Ranjan, Rajesh Kumar, Kaushik, Sandeep, Kumar, Sujeet, Verma, Vikash

“…Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is a newly emerging, highly transmissible, and pathogenic coronavirus in humans that has caused…”
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Mechanistic insights into global suppressors of protein folding defects by Chattopadhyay, Gopinath, Bhowmick, Jayantika, Manjunath, Kavyashree, Ahmed, Shahbaz, Goyal, Parveen, Varadarajan, Raghavan

“…Most amino acid substitutions in a protein either lead to partial loss-of-function or are near neutral. Several studies have shown the existence of second-site…”
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Prediction of Residue-specific Contributions to Binding and Thermal Stability Using Yeast Surface Display by Ahmed, Shahbaz, Bhasin, Munmun, Manjunath, Kavyashree, Varadarajan, Raghavan

“…Accurate prediction of residue burial as well as quantitative prediction of residue-specific contributions to protein stability and activity is challenging,…”
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Differential activities of the two closely related withanolides, Withaferin A and Withanone: bioinformatics and experimental evidences by Vaishnavi, Kirti, Saxena, Nishant, Shah, Navjot, Singh, Rumani, Manjunath, Kavyashree, Uthayakumar, M, Kanaujia, Shankar P, Kaul, Sunil C, Sekar, Kanagaraj, Wadhwa, Renu

“…Withanolides are naturally occurring chemical compounds. They are secondary metabolites produced via oxidation of steroids and structurally consist of a…”
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Target-based drug discovery: Applications of fluorescence techniques in high throughput and fragment-based screening by Kumar, Vikrant, Chunchagatta Lakshman, Puneeth Kumar, Prasad, Thazhe Kootteri, Manjunath, Kavyashree, Bairy, Sneha, Vasu, Akshaya S., Ganavi, B., Jasti, Subbarao, Kamariah, Neelagandan

“…Target-based discovery of first-in-class therapeutics demands an in-depth understanding of the molecular mechanisms underlying human diseases. Precise…”
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Combining cysteine scanning with chemical labeling to map protein-protein interactions and infer bound structure in an intrinsically disordered region by Ahmed, Shahbaz, Chattopadhyay, Gopinath, Manjunath, Kavyashree, Bhasin, Munmun, Singh, Neelam, Rasool, Mubashir, Das, Sayan, Rana, Varsha, Khan, Neha, Mitra, Debarghya, Asok, Aparna, Singh, Ramandeep, Varadarajan, Raghavan

“…The Mycobacterium tuberculosis genome harbours nine toxin-antitoxin (TA) systems of the mazEF family. These consist of two proteins, a toxin and an antitoxin,…”
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Structural and functional determinants inferred from deep mutational scans by Bajaj, Priyanka, Manjunath, Kavyashree, Varadarajan, Raghavan

“…Mutations that affect protein binding to a cognate partner primarily occur either at buried residues or at exposed residues directly involved in partner…”
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Molecular Dynamics Perspective on the Protein Thermal Stability: A Case Study Using SAICAR Synthetase by Manjunath, Kavyashree, Sekar, Kanagaraj

“…The enzyme SAICAR synthetase ligates aspartate with CAIR (5′-phosphoribosyl-4-carboxy-5-aminoimidazole) forming SAICAR…”
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Identification of stabilizing point mutations through mutagenesis of destabilized protein libraries by Ahmed, Shahbaz, Manjunath, Kavyashree, Chattopadhyay, Gopinath, Varadarajan, Raghavan

“…Although there have been recent transformative advances in the area of protein structure prediction, prediction of point mutations that improve protein…”
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Mutational scan inferred binding energetics and structure in intrinsically disordered protein CcdA by Chandra, Soumyanetra, Manjunath, Kavyashree, Asok, Aparna, Varadarajan, Raghavan

“…Unlike globular proteins, mutational effects on the function of Intrinsically Disordered Proteins (IDPs) are not well‐studied. Deep Mutational Scanning of a…”
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A facile method of mapping HIV-1 neutralizing epitopes using chemically masked cysteines and deep sequencing by Datta, Rohini, Chowdhury, Rohan Roy, Manjunath, Kavyashree, Hanna, Luke Elizabeth, Varadarajan, Raghavan

“…Identification of specific epitopes targeted by neutralizing antibodies is essential to advance epitope-based vaccine design strategies. We report a facile…”
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Catalytic pathway, substrate binding and stability in SAICAR synthetase: A structure and molecular dynamics study by Manjunath, Kavyashree, Jeyakanthan, Jeyaraman, Sekar, Kanagaraj

“…The de novo purine biosynthesis is one of the highly conserved pathways among all organisms and is essential for the cell viability. A clear understanding of…”
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Targeting Phosphopeptide Recognition by the Human BRCA1 Tandem BRCT Domain to Interrupt BRCA1-Dependent Signaling by Periasamy, Jayaprakash, Kurdekar, Vadiraj, Jasti, Subbarao, Nijaguna, Mamatha B, Boggaram, Sanjana, Hurakadli, Manjunath A, Raina, Dhruv, Kurup, Lokavya Meenakshi, Chintha, Chetan, Manjunath, Kavyashree, Goyal, Aneesh, Sadasivam, Gayathri, Bharatham, Kavitha, Padigaru, Muralidhara, Potluri, Vijay, Venkitaraman, Ashok R

“…Intracellular signals triggered by DNA breakage flow through proteins containing BRCT (BRCA1 C-terminal) domains. This family, comprising 23 conserved…”
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Structure of SAICAR synthetase from Pyrococcus horikoshii OT3: Insights into thermal stability by Manjunath, Kavyashree, Kanaujia, Shankar Prasad, Kanagaraj, Surekha, Jeyakanthan, Jeyaraman, Sekar, Kanagaraj

“…The first native crystal structure of Phosphoribosylaminoimidazole-succinocarboxamide synthetase (SAICAR synthetase) from a hyperthermophilic organism…”
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Cloning, expression, purification, crystallization and preliminary X-ray crystallographic study of the putative SAICAR synthetase (PH0239) from Pyrococcus horikoshii OT3 by Manjunath, Kavyashree, Jeyakanthan, Jeyaraman, Nakagawa, Noriko, Shinkai, Akeo, Yoshimura, Masato, Kuramitsu, Seiki, Yokoyama, Shigeyuki, Sekar, Kanagaraj

“…The study of proteins involved in de novo biosynthesis of purine nucleotides is central in the development of antibiotics and anticancer drugs. In view of…”
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