Search Results - "Manivannan, Sathiyanarayanan"

Single-cell transcriptomic profiling unveils dysregulation of cardiac progenitor cells and cardiomyocytes in a mouse model of maternal hyperglycemia by Manivannan, Sathiyanarayanan, Mansfield, Corrin, Zhang, Xinmin, Kodigepalli, Karthik M., Majumdar, Uddalak, Garg, Vidu, Basu, Madhumita

“…Congenital heart disease (CHD) is the most prevalent birth defect, often linked to genetic variations, environmental exposures, or combination of both…”
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Single-cell RNA-sequencing analysis of aortic valve interstitial cells demonstrates the regulation of integrin signaling by nitric oxide by Majumdar, Uddalak, Choudhury, Talita Z, Manivannan, Sathiyanarayanan, Ueyama, Yukie, Basu, Madhumita, Garg, Vidu

“…Calcific aortic valve disease (CAVD) is an increasingly prevalent condition among the elderly population that is associated with significant morbidity and…”
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miR‐145 transgenic mice develop cardiopulmonary complications leading to postnatal death by Thomas, Shelby, Manivannan, Sathiyanarayanan, Sawant, Dwitiya, Kodigepalli, Karthik M., Garg, Vidu, Conway, Simon J., Lilly, Brenda

“…Background Both downregulation and elevation of microRNA miR‐145 has been linked to an array of cardiopulmonary phenotypes, and a host of studies suggest that…”
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A Multi-Omics Approach Using a Mouse Model of Cardiac Malformations for Prioritization of Human Congenital Heart Disease Contributing Genes by Matos-Nieves, Adrianna, Manivannan, Sathiyanarayanan, Majumdar, Uddalak, McBride, Kim L, White, Peter, Garg, Vidu

“…Congenital heart disease (CHD) is the most common type of birth defect, affecting ~1% of all live births. Malformations of the cardiac outflow tract (OFT)…”
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Abstract 18288: Mice Harboring a Novel De Novo Missense RBFOX2 Variant Display Abnormal Heart Development by Choudhury, Talita, Manivannan, Sathiyanarayanan, Gordon, David, Cameron, Emily, Girard, Holly, Myers, Katherine, White, Peter, Garg, Vidu

“…Abstract only Hypoplastic Left Heart Syndrome (HLHS) is a complex form of congenital heart disease, characterized by severe underdevelopment of the left…”
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Single-Cell RNA Sequencing Reveals Novel Genes Regulated by Hypoxia in the Lung Vasculature by Thomas, Shelby, Manivannan, Sathiyanarayanan, Garg, Vidu, Lilly, Brenda

“…Pulmonary arterial hypertension (PAH) is a chronic progressive disease with significant morbidity and mortality. The disease is characterized by vascular…”
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Abstract P3087: Single-cell Transcriptomics Reveals Cell-type Specific Transcriptional Responses In Murine Embryonic Hearts Exposed To Maternal Hyperglycemia by Manivannan, Sathiyanarayanan, Mansfield, Corrin R, Zhang, Xinmin, Kodigepalli, Madhav Karthik, Majumdar, Uddalak, Garg, Vidu, Basu, Madhumita

“…Congenital heart disease (CHD) is a significant pediatric health burden in the United States and a leading non-infectious cause of mortality in the infants…”
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Abstract 11984: A Novel Pathogenic Gata6 Variant Identified in a Family With Persistent Truncus Arteriosus, Childhood-Onset Diabetes Mellitus and Spontaneous Intestinal Perforation by Yasuhara, Jun, Manivannan, Sathiyanarayanan, Majumdar, Uddalak, Gordon, David, Myers, Katherine, Zender, Gloria, McBride, Kim L, White, Peter, Garg, Vidu

“…GATA6 is a member of the GATA family of transcription factors, among which GATA4, 5 and 6 are known to play critical roles during heart development. Pathogenic…”
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Abstract 436: Maternal Pregestational Diabetes Alters Fetal Gene Regulatory Program to Cause Spectrum of Congenital Heart Defects by Mansfield, Corrin, Manivannan, Sathiyanarayanan, Zhang, Xinmin, Kodigepalli, Madhav K, Garg, Vidu, Basu, Madhumita

“…Abstract only Maternal pre-gestational diabetes results in range of congenital malformations with significantpreponderance of congenital heart defects (CHD)…”
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Abstract 650: Dose-response Effect of Hyperglycemia in Maternal Diabetes Mediated Congenital Heart Defects by Mansfield, Corrin, Manivannan, Sathiyanarayanan, Cameron, Emily M, Garg, Vidu, Basu, Madhumita

“…Abstract only Congenital heart defects (CHDs) are the leading cause of infant morbidity and mortality. The etiology is multifactorial and maternal pre-existing…”
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Nitric oxide prevents aortic valve calcification by S-nitrosylation of USP9X to activate NOTCH signaling by Majumdar, Uddalak, Manivannan, Sathiyanarayanan, Basu, Madhumita, Ueyama, Yukie, Blaser, Mark C, Cameron, Emily, McDermott, Michael R, Lincoln, Joy, Cole, Susan E, Wood, Stephen, Aikawa, Elena, Lilly, Brenda, Garg, Vidu

“…Calcific aortic valve disease (CAVD) is an increasingly prevalent condition, and endothelial dysfunction is implicated in its etiology. We previously…”
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Generation of transgenic mice that conditionally express microRNA miR‐145 by Sawant, Dwitiya, Klevenow, Emilie, Baeten, Jeremy T., Thomas, Shelby, Manivannan, Sathiyanarayanan, Conway, Simon J., Lilly, Brenda

“…Summary MicroRNAs are modulators of cellular phenotypes and their functions contribute to development, homeostasis, and disease. miR‐145 is a conserved…”
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Abstract 16078: Novel Myl2 Variant Identified Through Exome Sequencing of an Autosomal Recessive Form of Hypertrophic Cardiomyopathy by Manivannan, Sathiyanarayanan, Darouich, Sihem, Masmoudi, Aida, Gordon, David, Zender, Gloria, Fitzgerald-Butt, Sara, Lariani, Imeni, McBride, Kim, White, Peter, Kharrat, Maher, Garg, Vidu

“…Massively parallel sequencing technologies have allowed for the discovery of disease-causing mutations in children with rare diseases. Here, we report a…”
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