Search Results - "Manimekalai, Malathy Sony Subramanian"

Variations of Subunit ε of the Mycobacterium tuberculosis F1Fo ATP Synthase and a Novel Model for Mechanism of Action of the Tuberculosis Drug TMC207 by BIUKOVIC, Goran, BASAK, Sandip, SUBRAMANIAN MANIMEKALAI, Malathy Sony, RISHIKESAN, Sankaranarayanan, ROESSLE, Manfred, DICK, Thomas, RAO, Srinivasa P. S, HUNKE, Cornelia, GRÜBER, Gerhard

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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AhpC of the mycobacterial antioxidant defense system and its interaction with its reducing partner Thioredoxin-C by Wong, Chui Fann, Shin, Joon, Subramanian Manimekalai, Malathy Sony, Saw, Wuan Geok, Yin, Zhan, Bhushan, Shashi, Kumar, Arvind, Ragunathan, Priya, Grüber, Gerhard

“…Despite the highly oxidative environment of the phagosomal lumen, the need for maintaining redox homeostasis is a critical aspect of mycobacterial biology. The…”
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Geometrical Analysis to Understand the Ability of Halogen Atoms to Act as Hydrogen-Bond Acceptors: A Structural Database Study by Malathy Sony, Subramanian Manimekalai, Ponnuswamy, Mondikalipudur Nanjappa

“…Non-covalent interactions involving halogen atoms play a major role in supramolecular chemistry, biochemistry, coordination and organometallic chemistry and…”
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ATP synthases from archaea: The beauty of a molecular motor by Grüber, Gerhard, Manimekalai, Malathy Sony Subramanian, Mayer, Florian, Müller, Volker

“…Archaea live under different environmental conditions, such as high salinity, extreme pHs and cold or hot temperatures. How energy is conserved under such…”
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Substrate‐induced structural alterations of Mycobacterial mycothione reductase and critical residues involved by Kumar, Arvind, Subramanian Manimekalai, Malathy Sony, Grüber, Gerhard

“…Redox homeostasis is a prerequisite for survival of the pathogen Mycobacterium tuberculosis (Mtb) which employs the low molecular weight thiol mycothiol (MSH)…”
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The uniqueness of subunit α of mycobacterial F-ATP synthases: An evolutionary variant for niche adaptation by Ragunathan, Priya, Sielaff, Hendrik, Sundararaman, Lavanya, Biuković, Goran, Subramanian Manimekalai, Malathy Sony, Singh, Dhirendra, Kundu, Subhashri, Wohland, Thorsten, Frasch, Wayne, Dick, Thomas, Grüber, Gerhard

“…The F1F0 -ATP (F-ATP) synthase is essential for growth of Mycobacterium tuberculosis, the causative agent of tuberculosis (TB). In addition to their synthase…”
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Atomic structure of, and valine binding to the regulatory ACT domain of the Mycobacterium tuberculosis Rel protein by Shin, Joon, Singal, Bharti, Sony Subramanian Manimekalai, Malathy, Wei Chen, Ming, Ragunathan, Priya, Grüber, Gerhard

“…The stringent response (SR) is crucial for survival as well as optimal growth of Mycobacterium tuberculosis (Mtb). Mycobacterial cells initiate SR during…”
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Mycobacterium tuberculosis PanD Structure–Function Analysis and Identification of a Potent Pyrazinoic Acid-Derived Enzyme Inhibitor by Ragunathan, Priya, Cole, Malcolm, Latka, Chitra, Aragaw, Wassihun Wedajo, Hegde, Pooja, Shin, Joon, Subramanian Manimekalai, Malathy Sony, Rishikesan, Sankaranarayanan, Aldrich, Courtney C, Dick, Thomas, Grüber, Gerhard

“…A common strategy employed in antibacterial drug discovery is the targeting of biosynthetic processes that are essential and specific for the pathogen…”
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Structure and flexibility of non-structural proteins 3 and -5 of Dengue- and Zika viruses in solution by Saw, Wuan Geok, Pan, Ankita, Subramanian Manimekalai, Malathy Sony, Grüber, Ardina, Grüber, Gerhard

“…Dengue- (DENV) and Zika viruses (ZIKV) rely on their non-structural protein 5 (NS5) including a methyl-transferase (MTase) and a RNA-dependent RNA polymerase…”
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Features and Functional Importance of Key Residues of the Mycobacterium tuberculosis Cytochrome bd Oxidase by Sviriaeva, Ekaterina, Subramanian Manimekalai, Malathy Sony, Grüber, Gerhard, Pethe, Kevin

“…Cytochrome bd (cyt-bd) oxygen reductases have a high affinity to oxygen and use the two electrons provided by ubiquinol or menaquinol, like in mycobacteria, to…”
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Identification of the critical linker residues conferring differences in the compactness of NS5 from Dengue virus serotype 4 and NS5 from Dengue virus serotypes 1-3 by Subramanian Manimekalai, Malathy Sony, Saw, Wuan Geok, Pan, Ankita, Grüber, Ardina, Grüber, Gerhard

“…Dengue virus (DENV) nonstructural protein 5 (NS5) consists of a methyltransferase (MTase) domain and an RNA‐dependent RNA polymerase (RdRp) domain. The…”
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Structural features of NS3 of Dengue virus serotypes 2 and 4 in solution and insight into RNA binding and the inhibitory role of quercetin by Pan, Ankita, Saw, Wuan Geok, Subramanian Manimekalai, Malathy Sony, Grüber, Ardina, Joon, Shin, Matsui, Tsutomu, Weiss, Thomas M., Grüber, Gerhard

“…Dengue virus (DENV), which has four serotypes (DENV‐1 to DENV‐4), is the causative agent of the viral infection dengue. DENV nonstructural protein 3 (NS3)…”
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Structure, mechanism and ensemble formation of the alkylhydroperoxide reductase subunits AhpC and AhpF from Escherichia coli by Dip, Phat Vinh, Kamariah, Neelagandan, Subramanian Manimekalai, Malathy Sony, Nartey, Wilson, Balakrishna, Asha Manikkoth, Eisenhaber, Frank, Eisenhaber, Birgit, Grüber, Gerhard

“…Hydroperoxides are reactive oxygen species (ROS) that are toxic to all cells and must be converted into the corresponding alcohols to alleviate oxidative…”
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Low resolution solution structure of HAMLET and the importance of its alpha-domains in tumoricidal activity by Ho, C S James, Rydstrom, Anna, Manimekalai, Malathy Sony Subramanian, Svanborg, Catharina, Grüber, Gerhard

“…HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells) is the first member in a new family of protein-lipid complexes with broad tumoricidal activity…”
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Nucleotide Binding States of Subunit A of the A-ATP Synthase and the Implication of P-Loop Switch in Evolution by Kumar, Anil, Manimekalai, Malathy Sony Subramanian, Balakrishna, Asha Manikkoth, Jeyakanthan, Jeyaraman, Grüber, Gerhard

“…The crystal structures of the nucleotide-empty (A E), 5′-adenylyl-β,γ-imidodiphosphate (A PNP)-bound, and ADP (A DP)-bound forms of the catalytic A subunit of…”
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Crystal and solution structure of the C-terminal part of the Methanocaldococcus jannaschii A₁AO ATP synthase subunit E revealed by X-ray diffraction and small-angle X-ray scattering by Balakrishna, Asha Manikkoth, Manimekalai, Malathy Sony Subramanian, Hunke, Cornelia, Gayen, Shovanlal, Rössle, Manfred, Jeyakanthan, Jeyaraman, Grüber, Gerhard

“…The structure of the C-terminus of subunit E (E₁₀₁₋₂₀₆) of Methanocaldococcus jannaschii A-ATP synthase was determined at 4.1 Å. E₁₀₁₋₂₀₆ consist of a…”
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Crystal Structure of Subunits D and F in Complex Gives Insight into Energy Transmission of the Eukaryotic V-ATPase from Saccharomyces cerevisiae by Balakrishna, Asha Manikkoth, Basak, Sandip, Manimekalai, Malathy Sony Subramanian, Grüber, Gerhard

“…Eukaryotic V1VO-ATPases hydrolyze ATP in the V1 domain coupled to ion pumping in VO. A unique mode of regulation of V-ATPases is the reversible disassembly of…”
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Crystallographic and solution structure of the N‐terminal domain of the Rel protein from Mycobacterium tuberculosis by Singal, Bharti, Balakrishna, Asha Manikkoth, Nartey, Wilson, Manimekalai, Malathy Sony Subramanian, Jeyakanthan, Jeyaraman, Grüber, Gerhard

“…Modulation of intracellular guanosine 3′,5′‐bispyrophosphate ((p)ppGpp) level, the effector of the stringent response, is crucial for survival as well as…”
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Redox chemistry of Mycobacterium tuberculosis alkylhydroperoxide reductase E (AhpE): Structural and mechanistic insight into a mycoredoxin-1 independent reductive pathway of AhpE via mycothiol by Kumar, Arvind, Balakrishna, Asha Manikkoth, Nartey, Wilson, Manimekalai, Malathy Sony Subramanian, Grüber, Gerhard

“…Mycobacterium tuberculosis (Mtb) has the ability to persist within the human host for a long time in a dormant stage and re-merges when the immune system is…”
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