Search Results - "Manikhas, G"

FAST: a randomised phase II study of zolbetuximab (IMAB362) plus EOX versus EOX alone for first-line treatment of advanced CLDN18.2-positive gastric and gastro-oesophageal adenocarcinoma by Sahin, U., Türeci, Ö., Manikhas, G., Lordick, F., Rusyn, A., Vynnychenko, I., Dudov, A., Bazin, I., Bondarenko, I., Melichar, B., Dhaene, K., Wiechen, K., Huber, C., Maurus, D., Arozullah, A., Park, J.W., Schuler, M., Al-Batran, S.-E.

“…Claudin 18.2 (CLDN18.2) is contained within normal gastric mucosa epithelial tight junctions; upon malignant transformation, CLDN18.2 epitopes become exposed…”
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Abraxane®, a novel Cremophor®-free, albumin-bound particle form of paclitaxel for the treatment of advanced non-small-cell lung cancer by Green, M. R., Manikhas, G. M., Orlov, S., Afanasyev, B., Makhson, A. M., Bhar, P., Hawkins, M. J.

“…Background: Abraxane® (ABI-007) is a novel 130-nm, albumin-bound (nab™) particle form of paclitaxel designed to utilize endogenous albumin pathways to increase…”
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A phase III, double-blind, randomized trial of palonosetron compared with ondansetron in preventing chemotherapy-induced nausea and vomiting following highly emetogenic chemotherapy by Aapro, MS, Grunberg, SM, Manikhas, GM, Olivares, G, Suarez, T, Tjulandin, SA, Bertoli, LF, Yunus, F, Morrica, B, Lordick, F, Macciocchi, A

“…Background: This pivotal phase III trial evaluated the efficacy and safety of palonosetron in preventing acute and delayed chemotherapy-induced nausea and…”
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A randomised, double-blind, placebo-controlled phase 2 study of trebananib (AMG 386) in combination with FOLFIRI in patients with previously treated metastatic colorectal carcinoma by Peeters, M, Strickland, A H, Lichinitser, M, Suresh, A V S, Manikhas, G, Shapiro, J, Rogowski, W, Huang, X, Wu, B, Warner, D, Jain, R, Tebbutt, N C

“…Background: This phase 2 study evaluated trebananib (AMG 386), an investigational peptide-Fc fusion protein that neutralises the interaction between…”
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Comparison of the effectiveness of intraoperative radiotherapy with external beam radiotherapy in patients with early breast cancer by Manikhas, A. G., Gor, L. A., Topuzov, E. E., Morozova, A. V., Kalinin, I. V.

“…Background. Breast cancer is the most common cancer in women. The main treatment for breast cancer includes surgery, chemotherapy, radiation therapy, and…”
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B Lymphocytes Are a Predictive Marker of Eribulin Response and Overall Survival in Locally Advanced or Metastatic Breast Cancer: A Multicenter, Two-Cohort, Non-Randomized, Open-Label, Retrospective Study by Tashireva, Liubov A., Popova, Nataliya O., Kalinchuk, Anna Yu, Goldberg, Viktor E., Kovalenko, Elena I., Artamonova, Elena V., Manikhas, Aleksey G., Ponomarenko, Dmitriy M., Levchenko, Nataliya V., Rossokha, Elena I., Krasilnikova, Svetlana Yu, Zafirova, Marina A., Choynzonov, Evgeniy L., Perelmuter, Vladimir M.

“…Triple-negative breast cancer has no specific treatment and unfavorable prognosis. Eribulin is one of the drugs widely used in this cohort of patients. In…”
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First-Line Trastuzumab Plus Epirubicin and Cyclophosphamide Therapy in Patients With Human Epidermal Growth Factor Receptor 2–Positive Metastatic Breast Cancer: Cardiac Safety and Efficacy Data From the Herceptin, Cyclophosphamide, and Epirubicin (HERCULES) Trial by UNTCH, Michael, MUSCHOLL, Michael, HARBECK, Nadia, JACKISCH, Christian, MÜLLER, Volkmar, PAUSCHINGER, Matthias, THOMSSEN, Christoph, LEHLE, Michaela, CATALANI, Olivier, LÜCK, Hans-Joachim, TJULANDIN, Sergei, JONAT, Walter, MEERPOHL, Hans-Gerd, LICHINITSER, Mikhail, MANIKHAS, Alexey G, COUMBOS, Alexandra, KREIENBERG, Rolf, DU BOIS, Andreas

“…A high incidence of congestive heart failure (CHF) has been observed in patients with metastatic breast cancer (MBC) receiving doxorubicin-based chemotherapy…”
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Commentary to article Alexey L. Charyshkin, Evgenii A. Toneev, Alexander A. Martynov, Denis A. Semenov «Surgical treatment of giant GIST of the cardiac stomach by Manikhas, G. M.

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The approach of combination of breast cancer therapy using the intraoperative radiation therapy after neoadjuvant systemic therapy by Manikhas, A, Grinev, I, Oganesyan, A, Lee, L, Chikrizov, S, Manikhas, G

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Pharmacokinetic (PK) profile of quisinostat in combination with gemcitabine and cisplatin in patients (pts) with non-small cell lung cancer (NSCLC) or paclitaxel and carboplatin in pts with NSCLC or epithelial ovarian cancer by Fedyanin, M, Tjulandin, S, Cheporov, S, Vladimirov, V, Moiseenko, V, Orlov, S, Manikhas, G, Koryakova, A, Cakana, A, Phelps, C, Baranovsky, S, Azarova, V, Karavaeva, O, Vostokova, N

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Phase I, dose-finding study of AZD8931, an inhibitor of EGFR (erbB1), HER2 (erbB2) and HER3 (erbB3) signaling, in patients with advanced solid tumors by Tjulandin, S., Moiseyenko, V., Semiglazov, V., Manikhas, G., Learoyd, M., Saunders, A., Stuart, M., Keilholz, U.

“…Summary Aim AZD8931 is an oral equipotent inhibitor of EGFR (erbB1), HER2 (erbB2) and HER3 (erbB3) signaling. This Phase I, open-label study evaluated the…”
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A randomized phase II study of bortezomib and pemetrexed, in combination or alone, in patients with previously treated advanced non-small-cell lung cancer by Scagliotti, Giorgio V, Germonpré, Paul, Bosquée, Leon, Vansteenkiste, Johan, Gervais, R, Planchard, David, Reck, Martin, De Marinis, Filippo, Lee, Jin Soo, Park, Keunchil, Biesma, Bonne, Gans, Steven, Ramlau, R, Szczesna, Aleusandra, Makhson, A, Manikhas, G, Morgan, Bruno, Zhu, Y, Chan, Kai C, von Pawel, Joachim

“…Abstract Background This is a phase II randomized study to evaluate the efficacy and safety of bortezomib and pemetrexed alone or in combination, in patients…”
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The role of neoadjuvant chemotherapy of triple-negative breast cancer in St. Petersburg City Clinical Oncological Dispensary by Manikhas, A. G., Babeshkin, R. N., Paltuev, R. M., Manikhas, G. M.

“…Introduction. Triple-negative breast cancer (BC) is very aggressive form of breast malignancies with high levels of dissemination, frequent ecurrence and poor…”
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An open randomised trial of second-line endocrine therapy in advanced breast cancer: comparison of the aromatase inhibitors letrozole and anastrozole by Rose, C., Vtoraya, O., Pluzanska, A., Davidson, N., Gershanovich, M., Thomas, R., Johnson, S., Caicedo, J.J., Gervasio, H., Manikhas, G., Ben Ayed, F., Burdette-Radoux, S., Chaudri-Ross, H.A., Lang, R.

“…It was previously shown that letrozole (Femara®) was significantly more potent than anastrozole (Arimidex®) in inhibiting aromatase activity in vitro and in…”
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424 The Role of Cyclin D1 in Planning of Endocrine Therapy for Women of Postmenopausal Age with Breast Cancer by Skvortsov, V, Manikhas, G, Manikhas, A, Oganesyan, A, Raskin, G

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2LBA The first results of using intraoperative radiotherapy in treatment of women with breast cancer on early stages by Manikhas, A, Skvortsov, V, Manikhas, G, Oganesyn, A, Chekrizov, S, Le, L, Babeshkin, R, Fedorova, O

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Conservative treatment of early hormone-dependent breast cancer in elderly patients (65 years and older) by Manikhas, A. G., Pasekova, D. S.

“…Background. Standard treatment for hormone-dependent operable breast cancer includes surgery, hormone therapy (HT), and radiation therapy and chemotherapy…”
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Eribulin-trastuzumab combination in HER2-positive metastatic breast cancer: updated results from a Russian observational study by Kovalenko, E. I., Artamonova, E. V., Bolotina, L. V., Zhiliaeva, L. A., Ponomarenko, D. M., Karabina, E. V., Mukhametshina, G. Z., Khasanova, A. I., Ratner, E. Yu, Safarova, A. R., Manikhas, A. G., Popova, N. O., Evstigneeva, I. V., Vladimirova, L. Yu, Kramskaya, L. V., Karandeeva, T. V., Suslova, I. R., Romanchuk, O. V., Shikina, V. E., Povyshev, A. Yu, Osipov, M. A., Cherniakova, E. M., Dergunov, A. S., Volkonskiy, M. V., Chernov, I. S., Shumskaya, I. E., Fael, M. M., Garifullina, V. I., Gudkova, I. E.

“…Introduction . The standard of 1st line treatment of HER2+ metastatic breast cancer (mBC) is double blockade with trastuzumab and pertuzumab + taxane, 2nd…”
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Quality of Life of Elderly and Senile Patients with Hormone Receptor Positive Breast Cancer Using Primary Endocrine Therapy by Manikhas, A. G., Pasekova, D. S., Topuzov, E. E.

“…Introduction . Elderly and senile patients are a special category of patients and standard methods in breast cancer treatment are not suitable due to the…”
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A randomized phase II trial of doxorubicin plus pemetrexed followed by docetaxel versus doxorubicin plus cyclophosphamide followed by docetaxel as neoadjuvant treatment of early breast cancer by Schneeweiss, A., Marmé, F., Ruiz, A., Manikhas, A.G., Bottini, A., Wolf, M., Sinn, H.-P., Mansouri, K., Kennedy, L., Bauknecht, T.

“…Neoadjuvant systemic therapy (NST) before surgery is a standard option for patients with early breast cancer (EBC) that allows in vivo chemosensitivity…”
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