Effect of the Molecularly Imprinted Polymer Component Ratio on Analytical Performance

Effect of the Molecularly Imprinted Polymer Component Ratio on Analytical Performance

Molecular imprinting technology is a new analytical method that is highly selective and specific for certain analytes in artificial receptor design. The renewal possibilities of this technology make it an ideal material for sundry application fields. Molecularly imprinted polymers (MIPs) are polymer...

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Bibliographic Details
Published in:Chemical & pharmaceutical bulletin Vol. 68; no. 11; pp. 1013 - 1024
Main Authors: Pratama, Kelvin Fernando, Manik, Maretty Erwanta Roulina, Rahayu, Driyanti, Hasanah, Aliya Nur
Format: Journal Article
Language:English
Published: Japan The Pharmaceutical Society of Japan 01-11-2020
Pharmaceutical Society of Japan
Japan Science and Technology Agency
Subjects:
Analytical chemistry
Anti-Bacterial Agents - analysis
Anti-Bacterial Agents - isolation & purification
Antibodies
Cross-Linking Reagents - chemistry
Crosslinking
Imprinted polymers
imprinting factor
Mathematical analysis
Methacrylates - chemistry
Molecular imprinting
molecularly imprinted polymer analytical performance
molecularly imprinted polymer component
Molecularly Imprinted Polymers - chemistry
Monomers
Polymerization
Polymers
Receptors
Recognition
Selectivity
Solid Phase Extraction - methods
Solvents - chemistry
sorbent binding capacity
sorbent selectivity
Sorbents
Technology assessment
molecularly imprinted polymer component
sorbent binding capacity
sorbent selectivity
imprinting factor
molecularly imprinted polymer analytical performance
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Summary:Molecular imprinting technology is a new analytical method that is highly selective and specific for certain analytes in artificial receptor design. The renewal possibilities of this technology make it an ideal material for sundry application fields. Molecularly imprinted polymers (MIPs) are polymeric matrices that have molecules printed on their surfaces; these surfaces can chemically interact with molecules or follow the pattern of the available template cavities obtained using imprinting technology. A MIP is useful for separating and analysing complex samples, such as biological fluids and environmental samples, because it is a strong analytical recognition element that can mimick natural recognition entities like biological receptors and antibodies. The MIP components consist of the target template, functional monomer, crosslinker, polymerisation initiator, and porogen. The effectiveness and selectivity of a MIP are greatly influenced by variations in the components. This review will provide an overview of the effect of MIP component ratio on analytical performance to each target analyte; it will also provide a strategy to obtain the best MIP performance. For every MIP, each template : monomer : crosslinker ratio shows a distinct performance for a specific analyte. The effects of the template : monomer : crosslinker ratio on a MIP’s analytical performances—measured by the imprinting factor, sorbent binding capacity, and sorbent selectivity—are briefly outlined.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.c20-00551