Search Results - "Manifava, M"

Identification of ARAP3, a Novel PI3K Effector Regulating Both Arf and Rho GTPases, by Selective Capture on Phosphoinositide Affinity Matrices by Krugmann, S., Anderson, K.E., Ridley, S.H., Risso, N., McGregor, A., Coadwell, J., Davidson, K., Eguinoa, A., Ellson, C.D., Lipp, P., Manifava, M., Ktistakis, N., Painter, G., Thuring, J.W., Cooper, M.A., Lim, Z.-Y., Holmes, A.B., Dove, S.K., Michell, R.H., Grewal, A., Nazarian, A., Erdjument-Bromage, H., Tempst, P., Stephens, L.R., Hawkins, P.T.

“…We show that matrices carrying the tethered homologs of natural phosphoinositides can be used to capture and display multiple phosphoinositide binding proteins…”
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Phospholipase D1 and potential targets of its hydrolysis product, phosphatidic acid by Ktistakis, N T, Delon, C, Manifava, M, Wood, E, Ganley, I, Sugars, J M

“…Phospholipase D (PLD) hydrolyses phosphatidylcholine into phosphatidic acid (PA) and choline. Our work aims to understand the properties of PLD1, and to…”
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FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct functions in the endosomal and Golgi compartments by Ridley, S H, Ktistakis, N, Davidson, K, Anderson, K E, Manifava, M, Ellson, C D, Lipp, P, Bootman, M, Coadwell, J, Nazarian, A, Erdjument-Bromage, H, Tempst, P, Cooper, M A, Thuring, J W, Lim, Z Y, Holmes, A B, Stephens, L R, Hawkins, P T

“…FENS-1 and DFCP1 are recently discovered proteins containing one or two FYVE-domains respectively. We show that the FYVE domains in these proteins can bind…”
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Interaction of phospholipase D1 with a casein-kinase-2-like serine kinase by Ganley, I G, Walker, S J, Manifava, M, Li, D, Brown, H A, Ktistakis, N T

“…Phospholipase D (PLD)1 was phosphorylated in vivo and by an associated kinase in vitro following immunoprecipitation. Both phosphorylation events were greatly…”
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Stress-induced perturbations in intracellular amino acids reprogram mRNA translation in osmoadaptation independently of the ISR by Krokowski, Dawid, Jobava, Raul, Szkop, Krzysztof J., Chen, Chien-Wen, Fu, Xu, Venus, Sarah, Guan, Bo-Jhih, Wu, Jing, Gao, Zhaofeng, Banaszuk, Wioleta, Tchorzewski, Marek, Mu, Tingwei, Ropelewski, Phil, Merrick, William C., Mao, Yuanhui, Sevval, Aksoylu Inci, Miranda, Helen, Qian, Shu-Bing, Manifava, Maria, Ktistakis, Nicholas T., Vourekas, Anastasios, Jankowsky, Eckhard, Topisirovic, Ivan, Larsson, Ola, Hatzoglou, Maria

“…The integrated stress response (ISR) plays a pivotal role in adaptation of translation machinery to cellular stress. Here, we demonstrate an ISR-independent…”
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Cellular expression and function of phospholipase D1 by Ktistakis, N T, Manifava, M, Sugars, J, Bi, K, Roth, M G

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Sphingosine Kinase 1 Is an Intracellular Effector of Phosphatidic Acid by Delon, Christine, Manifava, Maria, Wood, Eleanor, Thompson, Dawn, Krugmann, Sonja, Pyne, Susan, Ktistakis, Nicholas T

“…Sphingosine kinase 1 (SK1) phosphorylates sphingosine to generate sphingosine 1-phosphate (S1P). Because both substrate and product of the enzyme are…”
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Dinucleotide repeat polymorphism at the GLUDP2 locus by Goulielmos, G, Manifava, M, Moschonas, N K

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A chromosome 10p11.2 Gt-dinucleotide repeat polymorphism at the GLUDP5 gene locus by Goulielmos, G, Angelicheva, D, Kapsetaki, M, Manifava, M, Moschonas, N K

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Dinucleotide repeat polymorphism (D10S608) adjacent to the GLUD1 locus by Moschonas, N K, Goulielmos, G, Lubyova, B, Manifava, M, Deloukas, P, Loon, A P, Kapsetaki, M

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Differential Binding of Traffic-related Proteins to Phosphatidic Acid- or Phosphatidylinositol (4,5)- Bisphosphate-coupled Affinity Reagents by Manifava, Maria, Thuring, Johannes W.J.F., Lim, Ze-Yi, Packman, Len, Holmes, Andrew B., Ktistakis, Nicholas T.

“…Phosphatidic acid (PA) is an important bioactive lipid, but its molecular targets remain unknown. To identify such targets, we have synthesized and coupled PA…”
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Fatty Acylation of Phospholipase D1 on Cysteine Residues 240 and 241 Determines Localization on Intracellular Membranes by Sugars, Jane M., Cellek, Selim, Manifava, Maria, Coadwell, John, Ktistakis, Nicholas T.

“…We have reported previously that phospholipase D1 (PLD1) is labeled specifically with [3 H]palmitate following transient expression and immunoprecipitation and…”
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Hierarchy of Membrane-targeting Signals of Phospholipase D1 Involving Lipid Modification of a Pleckstrin Homology Domain by Sugars, Jane M, Cellek, Selim, Manifava, Maria, Coadwell, John, Ktistakis, Nicholas T

“…The amino terminus of phospholipase D1 (PLD1) contains three potential membrane-interacting determinants: a phox homology (PX) domain, a pleckstrin homology…”
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Modification of Catalytically Active Phospholipase D1 with Fatty Acid in Vivo by Manifava, Maria, Sugars, Jane, Ktistakis, Nicholas T.

“…Phospholipase D1 (PLD1) was covalently labeled with 3H when expressed transiently in COS cells and immunoprecipitated following labeling of the cells with…”
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Immunolocalisation of phospholipase D1 on tubular vesicular membranes of endocytic and secretory origin by Lucocq, John, Manifava, Maria, Bi, Kun, Roth, Michael G., Ktistakis, Nicholas T.

“…We have examined the localisation of overexpressed phospholipase D1 (PLD1) using antibodies against its amino- and carboxyl-terminal domains. PLD1…”
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PA binding of phosphatidylinositol 4-phosphate 5-kinase by Stace, Catherine, Manifava, Maria, Delon, Christine, Coadwell, John, Cockcroft, Shamshad, Ktistakis, Nicholas T

“…Phosphatidic acid (PA) has been considered as a signaling lipid for many years, but its exact molecular targets or its mechanisms of action are still subjects…”
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