Search Results - "Manier, Sascha K"

Automated optimization of XCMS parameters for improved peak picking of liquid chromatography–mass spectrometry data using the coefficient of variation and parameter sweeping for untargeted metabolomics by Manier, Sascha K., Keller, Andreas, Meyer, Markus R.

“…Accurate peak picking and further processing is a current challenge in the analysis of untargeted metabolomics using liquid chromatography–mass spectrometry…”
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Evaluation of extraction methods for untargeted metabolomic studies for future applications in zebrafish larvae infection models by Schippers, Philip, Rasheed, Sari, Park, Yu Mi, Risch, Timo, Wagmann, Lea, Hemmer, Selina, Manier, Sascha K., Müller, Rolf, Herrmann, Jennifer, Meyer, Markus R.

“…Sample preparation in untargeted metabolomics should allow reproducible extractions of as many molecules as possible. Thus, optimizing sample preparation is…”
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Comparison of Three Untargeted Data Processing Workflows for Evaluating LC-HRMS Metabolomics Data by Hemmer, Selina, Manier, Sascha K., Fischmann, Svenja, Westphal, Folker, Wagmann, Lea, Meyer, Markus R.

“…The evaluation of liquid chromatography high-resolution mass spectrometry (LC-HRMS) raw data is a crucial step in untargeted metabolomics studies to minimize…”
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Characterization and Metabolism of Drug Products Containing the Cocaine-Like New Psychoactive Substances Indatraline and Troparil by Manier, Sascha K, Mumber, Paula, Zapp, Josef, Eckstein, Niels, Meyer, Markus R

“…With a rising demand of cocaine over the last years, it is likely that unregulated new psychoactive substances with similar effects such as indatraline ((1 ,3…”
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New Psychoactive Substances 3-Methoxyphencyclidine (3-MeO-PCP) and 3-Methoxyrolicyclidine (3-MeO-PCPy): Metabolic Fate Elucidated with Rat Urine and Human Liver Preparations and their Detectability in Urine by GC-MS, “LC-(High Resolution)-MSn” and “LC-(High Resolution)-MS/MS” by A Michely, Julian A, Manier, Sascha K, Caspar, Achim T, Brandt, Simon D, Wallach, Jason, Maurer, Hans H

“…Background: 3-Methoxyphencyclidine (3-MeO-PCP) and 3-methoxyrolicyclidine (3-MeOPCPy) are two new psychoactive substances (NPS). The aims of the present study…”
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Liquid Chromatography-High-Resolution Mass Spectrometry-Based In Vitro Toxicometabolomics of the Synthetic Cathinones 4-MPD and 4-MEAP in Pooled Human Liver Microsomes by Manier, Sascha K, Schwermer, Florian, Wagmann, Lea, Eckstein, Niels, Meyer, Markus R

“…Synthetic cathinones belong to the most often seized new psychoactive substances on an international level. This study investigated the toxicometabolomics,…”
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Time series of chicken stool metagenomics and egg metabolomics in changing production systems: preliminary insights from a proof-of-concept by Rosch, Michael E G, Rehner, Jacqueline, Schmartz, Georges P, Manier, Sascha K, Becker, Uta, Müller, Rolf, Meyer, Markus R, Keller, Andreas, Becker, Sören L, Keller, Verena

“…Different production systems of livestock animals influence various factors, including the gut microbiota. We investigated whether changing the conditions from…”
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Impact of four different extraction methods and three different reconstitution solvents on the untargeted metabolomics analysis of human and rat urine samples by Hemmer, Selina, Manier, Sascha K., Wagmann, Lea, Meyer, Markus R.

“…•Outcome of untargeted metabolomics studies is influenced by inappropriate sample preparation.•Selection of reconstitution solvent shows highest impact…”
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Comparison of reversed-phase, hydrophilic interaction, and porous graphitic carbon chromatography columns for an untargeted toxicometabolomics study in pooled human liver microsomes, rat urine, and rat plasma by Hemmer, Selina, Manier, Sascha K., Wagmann, Lea, Meyer, Markus R.

“…Introduction Untargeted metabolomics studies are expected to cover a wide range of compound classes with high chemical diversity and complexity. Thus,…”
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Untargeted metabolomics by high resolution mass spectrometry coupled to normal and reversed phase liquid chromatography as a tool to study the in vitro biotransformation of new psychoactive substances by Manier, Sascha K., Keller, Andreas, Schäper, Jan, Meyer, Markus R.

“…In 2016, several synthetic cathinones were seized by the State Bureau of Criminal Investigation Bavaria in Germany. Due to their previous appearances in other…”
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Can the Intake of a Synthetic Tryptamine be Detected Only by Blood Plasma Analysis? A Clinical Toxicology Case Involving 4-HO-MET by Wagmann, Lea, Manier, Sascha K, Meyer, Markus R

“…Tryptamines represent a group of hallucinogenic new psychoactive substances with increasing prevalence. Unfortunately, only limited data concerning their…”
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Analytical toxicology of the semi-synthetic cannabinoid hexahydrocannabinol studied in human samples, pooled human liver S9 fraction, rat samples and drug products using HPLC–HRMS-MS by Manier, Sascha K, Valdiviezo, Johannes Angert, Vollmer, Aline C, Eckstein, Niels, Meyer, Markus R

“…Abstract Hexahydrocannabinol (HHC) is an emerging semi-synthetic cannabinoid, which is obtained from cyclization of cannabidiol and subsequent hydrogenation…”
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Toxicometabolomics of the new psychoactive substances α-PBP and α-PEP studied in HepaRG cell incubates by means of untargeted metabolomics revealed unexpected amino acid adducts by Manier, Sascha K., Wagmann, Lea, Flockerzi, Veit, Meyer, Markus R.

“…Toxicometabolomics, essentially applying metabolomics to toxicology of endogenous compounds such as drugs of abuse or new psychoactive substances (NPS), can be…”
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Current Situation of the Metabolomics Techniques Used for the Metabolism Studies of New Psychoactive Substances by Manier, Sascha K., Meyer, Markus R.

“…The purpose of this short overview is to summarize and discuss the English-written and PubMed-listed review articles and original studies published between…”
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Investigations on the in vitro and in vivo metabolic fate of the new synthetic opioid desmethylmoramide using HPLC–HRMS/MS for toxicological screening purposes by Manier, Sascha K., Valdiviezo, Johannes Angert, Eckstein, Niels, Meyer, Markus R.

“…New synthetic opioids are an increasing challenge for clinical and forensic toxicologists that developed over the recent years. Desmethylmoramide (DMM), a…”
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Impact of the used solvent on the reconstitution efficiency of evaporated biosamples for untargeted metabolomics studies by Manier, Sascha K., Meyer, Markus R.

“…Introduction Untargeted metabolomics intends to objectively analyze a wide variety of compounds. Their diverse physicochemical properties make it difficult to…”
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Toxicokinetics and analytical toxicology of flualprazolam: metabolic fate, isozyme mapping, human plasma concentration, and main urinary excretion products by Wagmann, Lea, Manier, Sascha K, Bambauer, Thomas P, Felske, Christina, Eckstein, Niels, Flockerzi, Veit, Meyer, Markus R

“…An increasing number of benzodiazepine-type compounds are appearing on the new psychoactive substances market…”
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Studies on the In Vitro and In Vivo Metabolic Fate of the New Psychoactive Substance N-Ethyl-N-Propyltryptamine for Analytical Purposes by Manier, Sascha K, Felske, Christina, Zapp, Josef, Eckstein, Niels, Meyer, Markus R

“…Prerequisites for the reliable identification of substances in terms of forensic and clinical toxicology or doping control include knowledge about their…”
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The metabolic fate of two new psychoactive substances − 2‐aminoindane and N‐methyl‐2‐aminoindane − studied in vitro and in vivo to support drug testing by Manier, Sascha K., Felske, Christina, Eckstein, Niels, Meyer, Markus R.

“…The aim of this study was to characterize the in vitro and in vivo metabolism of 2‐aminoindane (2,3‐dihydro‐1H‐inden‐2‐amine, 2‐AI), and N‐methyl‐2‐aminoindane…”
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Flubromazolam-Derived Designer Benzodiazepines: Toxicokinetics and Analytical Toxicology of Clobromazolam and Bromazolam by Wagmann, Lea, Manier, Sascha K, Felske, Christina, Gampfer, Tanja M, Richter, Matthias J, Eckstein, Niels, Meyer, Markus R

“…Abstract Flubromazolam is widely known as highly potent designer benzodiazepine (DBZD). Recently, the two flubromazolam-derived new psychoactive substances…”
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