Search Results - "Manie, Serge"

The role of the unfolded protein response in cancer progression: From oncogenesis to chemoresistance by Madden, Emma, Logue, Susan E., Healy, Sandra J., Manie, Serge, Samali, Afshin

“…Tumour cells endure both oncogenic and environmental stresses during cancer progression. Transformed cells must meet increased demands for protein and lipid…”
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Modelling cancer metabolism in vitro: current improvements and future challenges by Dragic, Helena, Chaveroux, Cedric, Cosset, Erika, Manie, Serge N.

“…Advances in cancer biology over the past decades have revealed that metabolic adaptation of cancer cells is an essential aspect of tumorigenesis. However,…”
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CDYL2 Epigenetically Regulates MIR124 to Control NF-κB/STAT3-Dependent Breast Cancer Cell Plasticity by Siouda, Maha, Dujardin, Audrey D., Barbollat-Boutrand, Laetitia, Mendoza-Parra, Marco A., Gibert, Benjamin, Ouzounova, Maria, Bouaoud, Jebrane, Tonon, Laurie, Robert, Marie, Foy, Jean-Philippe, Lavergne, Vincent, Manie, Serge N., Viari, Alain, Puisieux, Alain, Ichim, Gabriel, Gronemeyer, Hinrich, Saintigny, Pierre, Mulligan, Peter

“…Epigenetic deregulation of gene transcription is central to cancer cell plasticity and malignant progression but remains poorly understood. We found that the…”
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Cellular mechanisms of endoplasmic reticulum stress signaling in health and disease. 3. Orchestrating the unfolded protein response in oncogenesis: an update by Manié, Serge N, Lebeau, Justine, Chevet, Eric

“…The endoplasmic reticulum (ER)-induced unfolded protein response (UPR) is an adaptive mechanism that is activated upon accumulation of misfolded proteins in…”
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Caspase-1 autoproteolysis is differentially required for NLRP1b and NLRP3 inflammasome function by Guey, Baptiste, Bodnar, Mélanie, Manié, Serge N., Tardivel, Aubry, Petrilli, Virginie

“…Inflammasomes are caspase-1–activating multiprotein complexes. The mouse nucleotide-binding domain and leucine rich repeat pyrin containing 1b (NLRP1b)…”
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ATF4-Dependent NRF2 Transcriptional Regulation Promotes Antioxidant Protection during Endoplasmic Reticulum Stress by Sarcinelli, Carmen, Dragic, Helena, Piecyk, Marie, Barbet, Virginie, Duret, Cédric, Barthelaix, Audrey, Ferraro-Peyret, Carole, Fauvre, Joelle, Renno, Toufic, Chaveroux, Cédric, Manié, Serge N

“…Endoplasmic reticulum (ER) stress generates reactive oxygen species (ROS) that induce apoptosis if left unabated. To limit oxidative insults, the ER stress…”
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p58(IPK)-mediated attenuation of the proapoptotic PERK-CHOP pathway allows malignant progression upon low glucose by Huber, Anne-Laure, Lebeau, Justine, Guillaumot, Patricia, Pétrilli, Virginie, Malek, Mouhannad, Chilloux, Julien, Fauvet, Frédérique, Payen, Léa, Kfoury, Alain, Renno, Toufic, Chevet, Eric, Manié, Serge N

“…As solid tumors expand, oxygen and nutrients become limiting owing to inadequate vascularization and diffusion. How malignant cells cope with this potentially…”
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The stress sensor GCN2 differentially controls ribosome biogenesis in colon cancer according to the nutritional context by Piecyk, Marie, Triki, Mouna, Laval, Pierre‐Alexandre, Duret, Cedric, Fauvre, Joelle, Cussonneau, Laura, Machon, Christelle, Guitton, Jerôme, Rama, Nicolas, Gibert, Benjamin, Ichim, Gabriel, Catez, Frederic, Bourdelais, Fleur, Durand, Sebastien, Diaz, Jean‐Jacques, Coste, Isabelle, Renno, Toufic, Manié, Serge N., Aznar, Nicolas, Ansieau, Stephane, Ferraro‐Peyret, Carole, Chaveroux, Cedric

“…Nutrient availability is a key determinant of tumor cell behavior. While nutrient‐rich conditions favor proliferation and tumor growth, scarcity, and…”
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Nutrient shortage triggers the hexosamine biosynthetic pathway via the GCN2-ATF4 signalling pathway by Chaveroux, Cédric, Sarcinelli, Carmen, Barbet, Virginie, Belfeki, Sofiane, Barthelaix, Audrey, Ferraro-Peyret, Carole, Lebecque, Serge, Renno, Toufic, Bruhat, Alain, Fafournoux, Pierre, Manié, Serge N.

“…The hexosamine biosynthetic pathway (HBP) is a nutrient-sensing metabolic pathway that produces the activated amino sugar UDP-N-acetylglucosamine, a critical…”
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CD44 Proteolysis Increases CREB Phosphorylation and Sustains Proliferation of Thyroid Cancer Cells by DE FALCO, Valentina, TAMBURRINO, Anna, VENTRE, Simona, CASTELLONE, Maria Domenica, MALEK, Mouhannad, MANIE, Serge N, SANTORO, Massimo

“…CD44 is a marker of cancer stem-like cells and epithelial-mesenchymal transition that is overexpressed in many cancer types, including thyroid carcinoma. At…”
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Addicted to secrete – novel concepts and targets in cancer therapy by Dejeans, Nicolas, Manié, Serge, Hetz, Claudio, Bard, Frédéric, Hupp, Ted, Agostinis, Patrizia, Samali, Afshin, Chevet, Eric

“…Highlights • The secretory pathway is instrumental to oncogenesis and tumor growth. • The secretory pathway mediates the adaptation of tumor cells to intrinsic…”
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Getting the better of ER stress by Mollereau, Bertrand, Manié, Serge, Napoletano, Francesco

“…Research over the past few years has highlighted the ability of the unfolded protein response (UPR) to minimize the deleterious effects of accumulated…”
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ER stress and hexosamine pathway during tumourigenesis: A pas de deux? by Vasseur, Sophie, Manié, Serge N

“…Abstract Both the hexosamine biosynthetic pathway (HBP) and the endoplasmic reticulum (ER) are considered sensors for the nutritional state of the cell. The…”
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Targeting ERK-MYD88 interaction leads to ERK dysregulation and immunogenic cancer cell death by Virard, François, Giraud, Stéphane, Bonnet, Mélanie, Magadoux, Léa, Martin, Laetitia, Pham, Thuy Ha, Skafi, Najwa, Deneuve, Sophie, Frem, Rita, Villoutreix, Bruno O., Sleiman, Nawal Hajj, Reboulet, Jonathan, Merabet, Samir, Chaptal, Vincent, Chaveroux, Cédric, Hussein, Nader, Aznar, Nicolas, Fenouil, Tanguy, Treilleux, Isabelle, Saintigny, Pierre, Ansieau, Stéphane, Manié, Serge, Lebecque, Serge, Renno, Toufic, Coste, Isabelle

“…The quest for targeted therapies is critical in the battle against cancer. The RAS/MAP kinase pathway is frequently implicated in neoplasia, with ERK playing a…”
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Simultaneous Measurement of Metabolite Concentration and Isotope Incorporation by Mass Spectrometry by Heuillet, Maud, Millard, Pierre, Cissé, Madi Y, Linares, Laetitia K, Létisse, Fabien, Manié, Serge, Le Cam, Laurent, Portais, Jean-Charles, Bellvert, Floriant

“…Studies of the topology, functioning, and regulation of metabolic systems are based on two main types of information that can be measured by mass spectrometry:…”
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MyD88 in DNA Repair and Cancer Cell Resistance to Genotoxic Drugs by KFOURY, Alain, LE CORF, Katy, EL SABEH, Rana, JOURNEAUX, Alexandra, BADRAN, Bassam, HUSSEIN, Nader, LEBECQUE, Serge, MANIE, Serge, RENNO, Toufic, COSTE, Isabelle

“…MyD88 is an adaptor molecule in Toll-like receptor and interleukin 1 receptor signaling implicated in tumorigenesis through proinflammatory mechanisms. We have…”
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The RET receptor: function in development and dysfunction in congenital malformation by Manié, Serge, Santoro, Massimo, Fusco, Alfredo, Billaud, Marc

“…Germline mutations in the RET proto-oncogene are responsible for two unrelated neural crest disorders: Hirschsprung disease, a congenital absence of the…”
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mTOR inhibitors activate PERK signaling and favor viability of gastrointestinal neuroendocrine cell lines by Freis, Patricia, Bollard, Julien, Lebeau, Justine, Massoma, Patrick, Fauvre, Joëlle, Vercherat, Cécile, Walter, Thomas, Manié, Serge, Roche, Colette, Scoazec, Jean-Yves, Ferraro-Peyret, Carole

“…mTOR and Unfolded Protein Response (UPR) are two signaling pathways frequently activated in cancer cells. The mTOR pathway has been shown to be up-regulated in…”
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The hexosamine pathway and coat complex II promote malignant adaptation to nutrient scarcity by Dragic, Helena, Barthelaix, Audrey, Duret, Cédric, Le Goupil, Simon, Laprade, Hadrien, Martin, Sophie, Brugière, Sabine, Couté, Yohann, Machon, Christelle, Guitton, Jerome, Rudewicz, Justine, Hofman, Paul, Lebecque, Serge, Chaveroux, Cedric, Ferraro-Peyret, Carole, Renno, Toufic, Manié, Serge N

“…The glucose-requiring hexosamine biosynthetic pathway (HBP), which produces UDP-N-acetylglucosamine for glycosylation reactions, promotes lung adenocarcinoma…”
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The Reorientation of T-Cell Polarity and Inhibition of Immunological Synapse Formation by CD46 Involves Its Recruitment to Lipid Rafts by Ludford-Menting, Mandy J., Crimeen-Irwin, Blessing, Oliaro, Jane, Pasam, Anupama, Williamson, David, Pedersen, Natalie, Guillaumot, Patricia, Christansen, Dale, Manie, Serge, Gaus, Katharina, Russell, Sarah M.

“…Many infectious agents utilize CD46 for infection of human cells, and therapeutic applications of CD46-binding viruses are now being explored. Besides…”
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