Does High Protein Intake During First Week of Life Improve Growth and Neurodevelopmental Outcome at 18 months Corrected Age in Extremely Preterm Infants?

Does High Protein Intake During First Week of Life Improve Growth and Neurodevelopmental Outcome at 18 months Corrected Age in Extremely Preterm Infants?

Objective To examine whether high protein intake during the first week of life alters the growth and neurodevelopmental outcomes at 18 mo corrected age (CA) in preterm infants born < 29 wk. Methods This was a retrospective cohort study of preterm infants (<29 wk) before and after introduction...

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Bibliographic Details
Published in:Indian journal of pediatrics Vol. 83; no. 9; pp. 915 - 921
Main Authors: Buddhavarapu, Siddartha, Manickaraj, Saranya, Lodha, Abhay, Soraisham, Amuchou Singh
Format: Journal Article
Language:English
Published: New Delhi Springer India 01-09-2016
Subjects:
Child Development
Dietary Proteins
Female
Gestational Age
Gynecology
Humans
Infant
Infant, Extremely Premature
Infant, Low Birth Weight
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases
Male
Medicine
Medicine & Public Health
Original Article
Pediatrics
Retrospective Studies
Neonate
Growth
Neurodevelopmental outcomes
Protein
Preterm
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Summary:Objective To examine whether high protein intake during the first week of life alters the growth and neurodevelopmental outcomes at 18 mo corrected age (CA) in preterm infants born < 29 wk. Methods This was a retrospective cohort study of preterm infants (<29 wk) before and after introduction of nutritional policy targeting higher protein intake during the first week of life. The authors compared the growth and neurodevelopmental outcomes at 18 mo CA between infants born before (epoch 1) and after (epoch 2) the introduction of nutrition policy. Results Of 171 eligible infants who completed follow-up at 18 mo CA, 87 (51 %) were in post intervention group (epoch 2). The mean (± SD) gestational age (26.3 ± 1.49 wk vs. 26.2 ± 1.48 wk) and birth weight (947 ± 220 g vs. 924 ± 225 g) were similar between the two groups. At 18 mo CA, there were no significant differences in the growth and neurodevelopmental impairment rates between the two groups. Logistic regression analysis revealed that high protein intake (>3.5 g/kg/d) was not associated with improved neurodevelopmental outcome (OR 1.49, 95 % CI 0.52–4.26). Conclusions High protein intake during the first week of age was not associated with better growth or neurodevelopmental outcome at 18 mo CA in preterm infants.
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ISSN:0019-5456
0973-7693
DOI:10.1007/s12098-015-1918-9