Search Results - "Manickam, Ravikumar"

PPARs and Microbiota in Skeletal Muscle Health and Wasting by Manickam, Ravikumar, Duszka, Kalina, Wahli, Walter

“…Skeletal muscle is a major metabolic organ that uses mostly glucose and lipids for energy production and has the capacity to remodel itself in response to…”
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NAD+ centric mechanisms and molecular determinants of skeletal muscle disease and aging by Wagner, Sabrina, Manickam, Ravikumar, Brotto, Marco, Tipparaju, Srinivas M.

“…The nicotinamide adenine dinucleotide (NAD + ) is an essential redox cofactor, involved in various physiological and molecular processes, including energy…”
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P7C3 ameliorates barium chloride‐induced skeletal muscle injury activating transcriptomic and epigenetic modulation of myogenic regulatory factors by Kim, Joung W., Manickam, Ravikumar, Sinha, Puja, Xuan, Wanling, Huang, Jian, Awad, Kamal, Brotto, Marco, Tipparaju, Srinivas M.

“…Skeletal muscle injury affects the quality of life in many pathologies, including volumetric muscle loss, contusion injury, and aging. We hypothesized that the…”
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Metronidazole Causes Skeletal Muscle Atrophy and Modulates Muscle Chronometabolism by Manickam, Ravikumar, Oh, Hui Yun Penny, Tan, Chek Kun, Paramalingam, Eeswari, Wahli, Walter

“…Antibiotics lead to increased susceptibility to colonization by pathogenic organisms, with different effects on the host-microbiota relationship. Here, we show…”
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Nampt activator P7C3 ameliorates diabetes and improves skeletal muscle function modulating cell metabolism and lipid mediators by Manickam, Ravikumar, Tur, Jared, Badole, Sachin L., Chapalamadugu, Kalyan C., Sinha, Puja, Wang, Zhiying, Russ, David W., Brotto, Marco, Tipparaju, Srinivas M.

“…Background Nicotinamide phosphoribosyltransferase (Nampt), a key enzyme in NAD salvage pathway is decreased in metabolic diseases, and its precise role in…”
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Negative auto-regulation of myostatin expression is mediated by Smad3 and microRNA-27 by McFarlane, Craig, Vajjala, Anuradha, Arigela, Harikumar, Lokireddy, Sudarsanareddy, Ge, XiaoJia, Bonala, Sabeera, Manickam, Ravikumar, Kambadur, Ravi, Sharma, Mridula

“…Growth factors, such as myostatin (Mstn), play an important role in regulating post-natal myogenesis. In fact, loss of Mstn has been shown to result in…”
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Depletion of Gram-Positive Bacteria Impacts Hepatic Biological Functions During the Light Phase by Oh, Hui Yun Penny, Ellero-Simatos, Sandrine, Manickam, Ravikumar, Tan, Nguan Soon, Guillou, Hervé, Wahli, Walter

“…Living organisms display internal biological rhythms, which are an evolutionarily conserved adaptation to the environment that drives their rhythmic behavioral…”
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Experimental determination of radial dose function and anisotropy function of GammaMed Plus 192Ir high-dose-rate brachytherapy source in a bounded water phantom and its comparison with egs_brachy Monte Carlo simulation by Buchapudi, Rekha, Manickam, Ravikumar, Chandaraj, Varatharaj

“…Objective: The aim of the present study is to experimentally measure the radial dose function g(r) and anisotropy function F(r,θ) of GammaMed Plus 192Ir…”
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Effect of Detector Orientation and Influence of Jaw Position in the Determination of Small-field Output Factor with Various Detectors for High-energy Photon Beams by Godson, Henry Finlay, Manickam, Ravikumar, Ponmalar, Y Retna, Ganesh, K M, Saminathan, Sathiyan, Chandraraj, Varatharaj, Kumar, A Sathish, George, Seby, Raman, Arun, Singh, Rabi Raja

“…Accurate dose measurements are difficult in small fields due to charge particle disequilibrium, partial source occlusion, steep dose gradient, and the finite…”
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Genetic deletion of Kvβ2 (AKR6) causes loss of muscle function and increased inflammation in mice by Manickam, Ravikumar, Virzi, Jazmine, Potti, Anish, Cheng, Feng, Russ, David W, Tipparaju, Srinivas M

“…The voltage-gated potassium channels (Kv) are complex ion channels with distinct roles in neurotransmission, electrical conductivity of the heart, and smooth…”
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In Regard to Page et al by Ravichandran, Ramamoorthy, MSc, Dip RP, PhD, FICNM, FICRO, FIMSA, MCMPI, Ravikumar, Manickam, MSc, Dip RP, PhD

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Measurements and Monte Carlo calculation of radial dose and anisotropy functions of BEBIG 60Co high-dose-rate brachytherapy source in a bounded water phantom by Reddy, Buchapudi, Chamberland, Marc, Ravikumar, Manickam, Varatharaj, Chandraraj

“…Purpose The study compared the experimentally measured radial dose function, g(r), and anisotropy function, F(r,θ), of a BEBIG 60Co (Co0.A86) high-dose-rate…”
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Deletion of Kvβ2 (AKR6) Attenuates Isoproterenol Induced Cardiac Injury with Links to Solute Carrier Transporter SLC41a3 and Circadian Clock Genes by Tur, Jared, Chapalamadagu, Kalyan C, Manickam, Ravikumar, Cheng, Feng, Tipparaju, Srinivas M

“…Kvβ subunits belong to the aldo-keto reductase superfamily, which plays a significant role in ion channel regulation and modulates the physiological responses…”
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Evaluation of optically stimulated luminescence dosimeter for exit dose in vivo dosimetry in radiation therapy by Ponmalar, Retna, Manickam, Ravikumar, Saminathan, Sathiyan, Ganesh, K, Raman, Arun, Godson, Henry

“…Aim: The aim of this study was to assess and analyze the exit dose in radiotherapy using optically stimulated luminescence dosimeter (OSLD) with therapeutic…”
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Comparison of four commercial devices for RapidArc and sliding window IMRT QA by Chandraraj, Varatharaj, Stathakis, Sotirios, Manickam, Ravikumar, Esquivel, Carlos, Supe, Sanjay S., Papanikolaou, Nikos

“…For intensity‐modulated radiation therapy, evaluation of the measured dose against the treatment planning calculated dose is essential in the context of…”
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The effect of influence quantities and detector orientation on small-field patient-specific IMRT QA: comparison of measurements with various ionization chambers by Godson, Henry Finlay, Manickam, Ravikumar, Saminathan, Sathiyan, Ganesh, Kadirampatti Mani, Ponmalar, Retna

“…Intensity-modulated radiation therapy (IMRT) requires a patient-specific quality assurance (QA) program to validate the treatment plan and a high level of…”
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Roles of Peroxisome Proliferator-Activated Receptor β/δ in skeletal muscle physiology by Manickam, Ravikumar, Wahli, Walter

“…More than two decades of studying Peroxisome Proliferator-Activated Receptors (PPARs) has led to an understanding of their implications in various…”
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Dosimetric evaluation of newly developed well-type ionization chamber for use in the calibration of brachytherapy sources by Saminathan, Sathiyan, Godson, Henry, Ponmalar, Retna, Manickam, Ravikumar, Mazarello, James

“…The well-type ionization chamber has been designed for convenient use in brachytherapy source strength calibration. The chamber has a volume of 240 cm 3 ,…”
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Activation of the Aryl Hydrocarbon Receptor During Pregnancy in the Mouse Alters Mammary Development Through Direct Effects on Stromal and Epithelial Tissues1 by Lew, Betina J, Manickam, Ravikumar, Lawrence, B. Paige

“…Activation of the aryl hydrocarbon receptor (AHR), an environment-sensing transcription factor, causes profound impairment of mammary gland differentiation…”
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Response of Nanodot Optically Stimulated Luminescence Dosimeters to Therapeutic Electron Beams by Ponmalar, Y Retna, Manickam, Ravikumar, Sathiyan, S, Ganesh, K M, Arun, R, Godson, Henry Finlay

“…Response of Al O :C-based nanoDot optically stimulated luminescence (OSL) dosimeter was studied for the dosimetry of 6, 9, 12, 16, and 20 MeV therapeutic…”
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