Search Results - "Manica Balasegaram"

Antibiotic development — economic, regulatory and societal challenges by Årdal, Christine, Balasegaram, Manica, Laxminarayan, Ramanan, McAdams, David, Outterson, Kevin, Rex, John H., Sumpradit, Nithima

“…Antibiotic resistance is undoubtedly one of the greatest challenges to global health, and the emergence of resistance has outpaced the development of new…”
Get full text

The time to address the antibiotic pipeline and access crisis is now by Balasegaram, Manica, Outterson, Kevin, Røttingen, John-Arne

“…[...]antibiotic candidates that have the greatest potential public health value must be selected, and trials should be conducted in the countries most…”
Get full text

Antimicrobial resistance - moving forward? by Lomazzi, Marta, Moore, Michael, Johnson, April, Balasegaram, Manica, Borisch, Bettina

“…When microorganisms (such as bacteria or viruses) are highly exposed to antimicrobial drugs, they can develop the capacity to defeat the drugs designed to…”
Get full text

EQUITABLE ACCESS by Balasegaram, Manica, Cohn, Jennifer

“…The COVID-19 epidemic has once again highlighted the challenges to achieve equitable access to critical antimicrobials and vaccines. The problem is…”
Get full text

Global burden of antimicrobial resistance: essential pieces of a global puzzle by Charani, Esmita, McKee, Martin, Balasegaram, Manica, Mendelson, Marc, Singh, Sanjeev, Holmes, Alison H

Get full text

Combination therapy for visceral leishmaniasis by van Griensven, Johan, MD, Balasegaram, Manica, MD, Meheus, Filip, MSc, Alvar, Jorge, MD, Lynen, Lutgarde, MD, Boelaert, Marleen, MD

“…Summary Combination therapy for the treatment of visceral leishmaniasis has increasingly been advocated as a way to increase treatment efficacy and tolerance,…”
Get full text

Diagnostic preparedness for infectious disease outbreaks by Perkins, Mark D, MD, Dye, Christopher, FRS, Balasegaram, Manica, MD, Bréchot, Christian, Prof, Mombouli, Jean-Vivien, PhD, Røttingen, John-Arne, Prof, Tanner, Marcel, Prof, Boehme, Catharina C, Dr

“…Summary Diagnostics are crucial in mitigating the effect of disease outbreaks. Because diagnostic development and validation are time consuming, they should be…”
Get full text

Hard to study, hard to treat: putting children at the centre of antibiotic research and development by Balasegaram, Manica, Pécoul, Bernard, Gray, Glenda, Sharland, Mike, Swaminathan, Soumya

“…Globally, infectious diseases remain a major cause of morbidity and mortality in children,1 and an estimated 214 000 newborn babies died from drug-resistant…”
Get full text

Maximising access to achieve appropriate human antimicrobial use in low-income and middle-income countries by Mendelson, Marc, Prof, Røttingen, John-Arne, Prof, Gopinathan, Unni, MD, Hamer, Davidson H, Prof, Wertheim, Heiman, MD, Basnyat, Buddha, MD, Butler, Christopher, Prof, Tomson, Göran, Prof, Balasegaram, Manica, MD

“…Summary Access to quality-assured antimicrobials is regarded as part of the human right to health, yet universal access is often undermined in low-income and…”
Get full text

Multidrug-resistant gonorrhea: A research and development roadmap to discover new medicines by Alirol, Emilie, Wi, Teodora E, Bala, Manju, Bazzo, Maria Luiza, Chen, Xiang-Sheng, Deal, Carolyn, Dillon, Jo-Anne R, Kularatne, Ranmini, Heim, Jutta, Hooft van Huijsduijnen, Rob, Hook, Edward W, Lahra, Monica M, Lewis, David A, Ndowa, Francis, Shafer, William M, Tayler, Liz, Workowski, Kimberly, Unemo, Magnus, Balasegaram, Manica

“…Emilie Alirol and colleagues discuss the development of new treatments for gonorrhea…”
Get full text

Treatment options for second-stage gambiense human African trypanosomiasis by Eperon, Gilles, Balasegaram, Manica, Potet, Julien, Mowbray, Charles, Valverde, Olaf, Chappuis, François

“…Treatment of second-stage gambiense human African trypanosomiasis relied on toxic arsenic-based derivatives for over 50 years. The availability and subsequent…”
Get more information

International cooperation to improve access to and sustain effectiveness of antimicrobials by Årdal, Christine, MBA, Outterson, Kevin, Prof, Hoffman, Steven J, JD, Ghafur, Abdul, Prof, Sharland, Mike, FRCPCH, Ranganathan, Nisha, MRCP, Smith, Richard, Prof, Zorzet, Anna, PhD, Cohn, Jennifer, MD, Pittet, Didier, Prof, Daulaire, Nils, MD, Morel, Chantal, MSc, Rizvi, Zain, BHSc, Balasegaram, Manica, MD, Dar, Osman A, FFPH, Heymann, David L, Prof, Holmes, Alison H, Prof, Moore, Luke S P, MPH, Laxminarayan, Ramanan, PhD, Mendelson, Marc, Prof, Røttingen, John-Arne, Prof

“…Summary Securing access to effective antimicrobials is one of the greatest challenges today. Until now, efforts to address this issue have been isolated and…”
Get full text

Shortage of essential antimicrobials: a major challenge to global health security by Shafiq, Nusrat, Pandey, Avaneesh Kumar, Malhotra, Samir, Holmes, Alison, Mendelson, Marc, Malpani, Rohit, Balasegaram, Manica, Charani, Esmita

“…The lack of access to safe and effective antimicrobials for human populations is a threat to global health security and a contributor to the emergence and…”
Get full text

Comparison of short-course multidrug treatment with standard therapy for visceral leishmaniasis in India: an open-label, non-inferiority, randomised controlled trial by Sundar, Shyam, Prof, Sinha, Prabhat Kumar, MD, Rai, Madhukar, Prof, Verma, Deepak Kumar, MBBS, Nawin, Kumar, MD, Alam, Shanawwaj, MBBS, Chakravarty, Jaya, MD, Vaillant, Michel, MPH, Verma, Neena, MD, Pandey, Krishna, MD, Kumari, Poonam, MD, Lal, Chandra Shekhar, PhD, Arora, Rakesh, MBBS, Sharma, Bhawna, DPharm, Ellis, Sally, BSc, Strub-Wourgaft, Nathalie, MD, Balasegaram, Manica, MD, Olliaro, Piero, MD, Das, Pradeep, PhD, Modabber, Farrokh, Prof

“…Summary Background Improved treatment approaches are needed for visceral leishmaniasis. We assessed the efficacy and safety of three potential short-course…”
Get full text

Safety and efficacy of short course combination regimens with AmBisome, miltefosine and paromomycin for the treatment of visceral leishmaniasis (VL) in Bangladesh by Rahman, Ridwanur, Goyal, Vishal, Haque, Rashidul, Jamil, Kazi, Faiz, Abul, Samad, Rasheda, Ellis, Sally, Balasegaram, Manica, Boer, Margriet den, Rijal, Suman, Strub-Wourgaft, Nathalie, Alves, Fabiana, Alvar, Jorge, Sharma, Bhawna

“…AmBisome therapy for VL has an excellent efficacy and safety profile and has been adopted as a first-line regimen in Bangladesh. Second-line treatment options…”
Get full text

Unavailability of old antibiotics threatens effective treatment for common bacterial infections by Tängdén, Thomas, Pulcini, Céline, Aagaard, Helle, Balasegaram, Manica, Hara, Gabriel Levy, Nathwani, Dilip, Sharland, Mike, Theuretzbacher, Ursula, Cars, Otto

“…Most infections are still caused by pathogens susceptible to generic antibiotics, which are often preferred to newer antibiotics because of lower risks for…”
Get full text

A roadmap for sustainably governing the global antimicrobial commons by Van Katwyk, Susan Rogers, Balasegaram, Manica, Boriello, Pete, Farrar, Jeremy, Giubilini, Alberto, Harrison, Mark, Kieny, Marie-Paule, Kirchhelle, Claas, Liu, Joanne, Outterson, Kevin, Pate, Muhammad Ali, Poirier, Mathieu, Røttingen, John-Arne, Savulescu, Julian, Sugden, Rebecca, Thamlikitkul, Visanu, Weldon, Isaac, Davies, Sally, Hoffman, Steven J

“…The President of the UN General Assembly (UNGA) should initiate a One Health high-level dialogue on AMR as early as spring, 2020, to follow-up on the recent…”
Get full text

Tackling antimicrobial resistance in neonatal sepsis by Folgori, Laura, Ellis, Sally J, Bielicki, Julia A, Heath, Paul T, Sharland, Mike, Balasegaram, Manica

Get full text

Efficacy and Safety of AmBisome in Combination with Sodium Stibogluconate or Miltefosine and Miltefosine Monotherapy for African Visceral Leishmaniasis: Phase II Randomized Trial by Wasunna, Monique, Njenga, Simon, Balasegaram, Manica, Alexander, Neal, Omollo, Raymond, Edwards, Tansy, Dorlo, Thomas P C, Musa, Brima, Ali, Mohammed Hassan Sharaf, Elamin, Mohammed Yasein, Kirigi, George, Juma, Rashid, Kip, Anke E, Schoone, Gerard J, Hailu, Asrat, Olobo, Joseph, Ellis, Sally, Kimutai, Robert, Wells, Susan, Khalil, Eltahir Awad Gasim, Strub Wourgaft, Nathalie, Alves, Fabiana, Musa, Ahmed

“…SSG&PM over 17 days is recommended as first line treatment for visceral leishmaniasis in eastern Africa, but is painful and requires hospitalization…”
Get full text

Liposomal amphotericin B as a treatment for human leishmaniasis by Balasegaram, Manica, Ritmeijer, Koert, Lima, Maria Angeles, Burza, Sakib, Ortiz Genovese, Gemma, Milani, Barbara, Gaspani, Sara, Potet, Julien, Chappuis, François

“…Leishmaniasis is a parasitic disease transmitted by phlebotomine sandflies. Between 700,000 and 1.2 million cases of cutaneous leishmaniasis and between…”
Get more information