Search Results - "Manibusan, Anthony"

A general approach to site-specific antibody drug conjugates by Tian, Feng, Lu, Yingchun, Manibusan, Anthony, Sellers, Aaron, Tran, Hon, Sun, Ying, Phuong, Trung, Barnett, Richard, Hehli, Brad, Song, Frank, DeGuzman, Michael J., Ensari, Semsi, Pinkstaff, Jason K., Sullivan, Lorraine M., Biroc, Sandra L., Ho Cho, Schultz, Peter G., DiJoseph, John, Dougher, Maureen, Ma, Dangshe, Dushin, Russell, Leal, Mauricio, Tchistiakova, Lioudmila, Feyfant, Eric, Gerber, Hans-Peter, Sapra, Puja

“…Using an expanded genetic code, antibodies with site-specifically incorporated nonnative amino acids were produced in stable cell lines derived from a CHO cell…”
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Discovery of Pyrophosphate Diesters as Tunable, Soluble, and Bioorthogonal Linkers for Site-Specific Antibody–Drug Conjugates by Kern, Jeffrey C, Cancilla, Mark, Dooney, Deborah, Kwasnjuk, Kristen, Zhang, Rena, Beaumont, Maribel, Figueroa, Isabel, Hsieh, SuChun, Liang, Linda, Tomazela, Daniela, Zhang, Jeffrey, Brandish, Philip E, Palmieri, Anthony, Stivers, Peter, Cheng, Mangeng, Feng, Guo, Geda, Prasanthi, Shah, Sanjiv, Beck, Andrew, Bresson, Damien, Firdos, Juhi, Gately, Dennis, Knudsen, Nick, Manibusan, Anthony, Schultz, Peter G, Sun, Ying, Garbaccio, Robert M

“…As part of an effort to examine the utility of antibody–drug conjugates (ADCs) beyond oncology indications, a novel pyrophosphate ester linker was discovered…”
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In vitro and in vivo evaluation of cysteine and site specific conjugated herceptin antibody-drug conjugates by Jackson, Dowdy, Atkinson, John, Guevara, Claudia I, Zhang, Chunying, Kery, Vladimir, Moon, Sung-Ju, Virata, Cyrus, Yang, Peng, Lowe, Christine, Pinkstaff, Jason, Cho, Ho, Knudsen, Nick, Manibusan, Anthony, Tian, Feng, Sun, Ying, Lu, Yingchun, Sellers, Aaron, Jia, Xiao-Chi, Joseph, Ingrid, Anand, Banmeet, Morrison, Kendall, Pereira, Daniel S, Stover, David

“…Antibody drug conjugates (ADCs) are monoclonal antibodies designed to deliver a cytotoxic drug selectively to antigen expressing cells. Several components of…”
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FGF21 Analogs of Sustained Action Enabled by Orthogonal Biosynthesis Demonstrate Enhanced Antidiabetic Pharmacology in Rodents by MU, James, PINKSTAFF, Jason, WU, Margaret, NORMAN, Thea C, RODRIGUEZ, Carlos G, KIMMEL, Bruce, METZGER, Joseph M, MANIBUSAN, Anthony, LEE, Darin, ZALLER, Dennis M, ZHANG, Bei B, DIMARCHI, Richard D, ZHIHUA LI, BERGER, Joel P, AXELROD, Douglas W, SKIDMORE, Lillian, NINA LI, MYLER, Heather, DALLAS-YANG, Qing, PUTNAM, Anna-Maria, JUN YAO, BUSSELL, Stuart

“…Fibroblast growth factor 21 (FGF21) mitigates many of the pathogenic features of type 2 diabetes, despite a short circulating half-life. PEGylation is a proven…”
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A CXCR4-Targeted Site-Specific Antibody-Drug Conjugate by Kularatne, Sumith A., Deshmukh, Vishal, Ma, Jennifer, Tardif, Virginie, Lim, Reyna K. V., Pugh, Holly M., Sun, Ying, Manibusan, Anthony, Sellers, Aaron J., Barnett, Richard S., Srinagesh, Shailaja, Forsyth, Jane S., Hassenpflug, Wolf, Tian, Feng, Javahishvili, Tsotne, Felding-Habermann, Brunhilde, Lawson, Brian R., Kazane, Stephanie A., Schultz, Peter G.

“…A chemically defined anti‐CXCR4–auristatin antibody–drug conjugate (ADC) was synthesized that selectively eliminates tumor cells overexpressing the CXCR4…”
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Antibody-drug conjugates: integrated bioanalytical and biodisposition assessments in lead optimization and selection by Beaumont, Maribel, Tomazela, Daniela, Hodges, Douglas, Ermakov, Grigori, Hsieh, Edward, Figueroa, Isabel, So, On-Yee, Song, Yaoli, Ma, Huiping, Antonenko, Svetlana, Mengesha, Wondwessen, Zhang, Yi Wei, Zhang, Shuli, Hseih, SuChun, Ayanoglu, Gulesi, Du, Xiaoyan, Rimmer, Eric, Judo, Michael, Vives, Franklin, Yearley, Jennifer H., Moon, Christina, Manibusan, Anthony, Knudsen, Nick, Beck, Andy, Bresson, Damien, Gately, Dennis, Neupane, Divas, Escandón, Enrique

“…Therapies based on monoclonal antibodies (mAbs) have delivered an impressive success in the clinics due to their exquisite specificity, potential for agonistic…”
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Abstract 480: Molecular mechanism of action of photoimmunotherapy with antibody-IR700 dye conjugates by Heim, Roger, Makings, Lew, Wiemann, Torsten, Manibusan, Anthony, Garcia-Guzman, Miguel

“…INTRODUCTION: Cancer cell-targeted photoimmunotherapy (PIT) is a platform technology under development for the treatment of various cancers. PIT is a drug and…”
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Novel Phosphate Modified Cathepsin B Linkers: Improving Aqueous Solubility and Enhancing Payload Scope of ADCs by Kern, Jeffrey C., Dooney, Deborah, Zhang, Rena, Liang, Linda, Brandish, Philip E., Cheng, Mangeng, Feng, Guo, Beck, Andrew, Bresson, Damien, Firdos, Juhi, Gately, Dennis, Knudsen, Nick, Manibusan, Anthony, Sun, Ying, Garbaccio, Robert M.

“…In an effort to examine the utility of antibody–drug conjugates (ADCs) beyond oncology indications, a novel phosphate bridged Cathepsin B sensitive linker was…”
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Comparison of bioanalytical methods for the quantitation of PEGylated human insulin by de Dios, Kristine, Manibusan, Anthony, Marsden, Robin, Pinkstaff, Jason

“…The quality of bioanalytical data is dependent upon selective, sensitive, and reproducible analytical methods. With evolving technologies available,…”
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Pegylated Fgf21 rapidly normalizes insulin-stimulated glucose utilization in diet-induced insulin resistant mice by Camacho, Raul C., Zafian, Peter T., Achanfuo-Yeboah, Joana, Manibusan, Anthony, Berger, Joel P.

“…Fibroblast growth factor 21 (FGF21) is a novel hormone-like polypeptide that when administered exogenously, has been shown to have beneficial effects on food…”
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Development of Anti-CD74 Antibody–Drug Conjugates to Target Glucocorticoids to Immune Cells by Brandish, Philip E, Palmieri, Anthony, Antonenko, Svetlana, Beaumont, Maribel, Benso, Lia, Cancilla, Mark, Cheng, Mangeng, Fayadat-Dilman, Laurence, Feng, Guo, Figueroa, Isabel, Firdos, Juhi, Garbaccio, Robert, Garvin-Queen, Laura, Gately, Dennis, Geda, Prasanthi, Haines, Christopher, Hseih, SuChun, Hodges, Douglas, Kern, Jeffrey, Knudsen, Nickolas, Kwasnjuk, Kristen, Liang, Linda, Ma, Huiping, Manibusan, Anthony, Miller, Paul L, Moy, Lily Y, Qu, Yujie, Shah, Sanjiv, Shin, John S, Stivers, Peter, Sun, Ying, Tomazela, Daniela, Woo, Hyun Chong, Zaller, Dennis, Zhang, Shuli, Zhang, Yiwei, Zielstorff, Mark

“…Glucocorticoids (GCs) are excellent anti-inflammatory drugs but are dose-limited by on-target toxicity. We sought to solve this problem by delivering GCs to…”
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Role of tRNA Orthogonality in an Expanded Genetic Code by Javahishvili, Tsotne, Manibusan, Anthony, Srinagesh, Shaila, Lee, Darin, Ensari, Semsi, Shimazu, Mark, Schultz, Peter G

“…We found that Methanocaldococcus jannaschii DSM2661 tyrosyl-tRNA synthetase (Mj E9RS), specifically evolved to charge its cognate tRNA with the unnatural amino…”
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Recruiting Cytotoxic T Cells to Folate-Receptor-Positive Cancer Cells by Kularatne, Sumith A., Deshmukh, Vishal, Gymnopoulos, Marco, Biroc, Sandra L., Xia, Jinming, Srinagesh, Shailaja, Sun, Ying, Zou, Ning, Shimazu, Mark, Pinkstaff, Jason, Ensari, Semsi, Knudsen, Nick, Manibusan, Anthony, Axup, Jun Y., Kim, Chan Hyuk, Smider, Vaughn V., Javahishvili, Tsotne, Schultz, Peter G.

“…A Fab‐ulous killer: An anti‐CD3 Fab‐folate conjugate that targets cytotoxic T cells to folate‐receptor‐positive (FR+) tumors results in efficient killing of…”
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Abstract LB-222: Optimization and preclinical characterization of highly potent and stable anti-CD70 ADCs for the potential treatment of CD70 positive cancers by Skidmore, Lillian, Cox, Kari, Kirtley, Jessica, Le, Tiep, Firdos, Juhi, Manibusan, Anthony, Fang, Shiao-Yan, Beck, Andy, Bhowmik, Shiva, Knudsen, Nick, Wang, Jianing, Sun, Ying, Ayala, Armando, Powell, Alyssa, Wahl, Alan, Tian, Feng, Humphreys, Robin

“…Antibody drug conjugates (ADCs) require coordinated optimization of antibody, linker, and payload to generate potent, specific, and stable cancer therapeutics…”
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Abstract 668: Folate conjugated site-specifically to anti-human-CD3-Fab is efficacious in mouse models of ovarian cancer by Biroc, Sandra L., Gymnopoulos, Marco, Srinagesh, Shailaja, Hayes, Brad, Knudsen, Nick, Manibusan, Anthony, Pinkstaff, Jason, Buss, Tim, Cox, Kari, Marsden, Robin, Skidmore, Lillian, Xia, Jinming, Sun, Ying, Zou, Ning, Javahishvili, Tsotne

“…Ovarian cancer affects ∼22,000 women in the US each year. Folate receptor (FOLR1) is overexpressed in a high proportion of ovarian tumors and is generally…”
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Folate Receptor–Targeted T cells for Cancer Immunotherapy by Kularatne, Sumith A., Deshmukh, Vishal, Gymnopoulos, Marco, Biroc, Sandra L., Xia, Jinming, Srinagesh, Shaila, Sun, Ying, Zou, Ning, Shimazu, Mark, Pinkstaff, Jason, Ensari, Semsi, Knudsen, Nick, Manibusan, Anthony, Axup, Jun, Kim, Chanhyuk, Smider, Vaughn, Javahishvili, Tsotne, Schultz, Peter G.

“…Herein, we describe the synthesis of a chemically defined anti-CD3 Fab-folate conjugate that targets cytotoxic T cells to folate receptor positive (FR + )…”
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Recruiting Cytotoxic TCells to Folate-Receptor-Positive Cancer Cells by Kularatne, Sumith A, Deshmukh, Vishal, Gymnopoulos, Marco, Biroc, Sandra L, Xia, Jinming, Srinagesh, Shailaja, Sun, Ying, Zou, Ning, Shimazu, Mark, Pinkstaff, Jason, Ensari, Semsi, Knudsen, Nick, Manibusan, Anthony, Axup, Jun Y, Kim, Chan Hyuk, Smider, Vaughn V, Javahishvili, Tsotne, Schultz, Peter G

“…A Fab-ulous killer: An anti-CD3 Fab-folate conjugate that targets cytotoxic Tcells to folate-receptor-positive (FR(+) ) tumors results in efficient killing of…”
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Abstract 5691: Novel site-specific antibody drug conjugates based on novel amino acid incorporation technology have improved pharmaceutical properties over conventional antibody drug conjugates by Sapra, Puja Sapra, Tchistiakova, Lioudmila, Dushin, Russell, Leal, Mauricio, DiJoseph, John, Veneziale, Robert, Feyfant, Eric, Gerber, HansPeter, Sun, Ying, Manibusan, Anthony, Lu, Yingchun, Sellers, Aaron, Phuong, Trung, DeGuzman, Michael, Ensari, Semsi, Barnett, Barney, Cho, Ho, Tian, Feng

“…We demonstrate here for the first time generation of ADCs by using EuCODETM technology that site-specifically incorporates novel amino acids into proteins in…”
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Recruiting Cytotoxic T Cells to Folate-Receptor-Positive Cancer Cells by Kularatne, Sumith A., Deshmukh, Vishal, Gymnopoulos, Marco, Biroc, Sandra L., Xia, Jinming, Srinagesh, Shailaja, Sun, Ying, Zou, Ning, Shimazu, Mark, Pinkstaff, Jason, Ensari, Semsi, Knudsen, Nick, Manibusan, Anthony, Axup, Jun Y., Kim, Chan Hyuk, Smider, Vaughn V., Javahishvili, Tsotne, Schultz, Peter G.

“…Antikörperhelfer: Ein (anti‐CD3 Fab)‐Folat‐Konjugat rekrutiert zytotoxische T‐Zellen zu folatrezeptorpositiven (FR+) Tumoren und bewirkt so eine effiziente…”
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A CXCR4-Targeted Site-Specific Antibody-Drug Conjugate by Kularatne, Sumith A., Deshmukh, Vishal, Ma, Jennifer, Tardif, Virginie, Lim, Reyna K. V., Pugh, Holly M., Sun, Ying, Manibusan, Anthony, Sellers, Aaron J., Barnett, Richard S., Srinagesh, Shailaja, Forsyth, Jane S., Hassenpflug, Wolf, Tian, Feng, Javahishvili, Tsotne, Felding-Habermann, Brunhilde, Lawson, Brian R., Kazane, Stephanie A., Schultz, Peter G.

“…A chemically defined anti‐CXCR4–auristatin antibody–drug conjugate (ADC) was synthesized that selectively eliminates tumor cells overexpressing the CXCR4…”
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