Search Results - "Mani, Neelakandha S."

Regioselective Synthesis of 1,3,5-Tri- and 1,3,4,5-Tetrasubstituted Pyrazoles from N-Arylhydrazones and Nitroolefins by Deng, Xiaohu, Mani, Neelakandha S

“…Two general protocols are developed for the regioselective synthesis of 1,3,5-tri- and 1,3,4,5-tetrasubstituted pyrazoles by the reaction of electron-deficient…”
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Oxysterols direct B-cell migration through EBI2 by Liu, Changlu, Yang, Xia V., Wu, Jiejun, Kuei, Chester, Mani, Neelakandha S., Zhang, Li, Yu, Jingxue, Sutton, Steven W., Qin, Ning, Banie, Homayon, Karlsson, Lars, Sun, Siquan, Lovenberg, Timothy W.

“…EBI2 receptors revealed as oxysterols The EBI2 receptor (Epstein–Barr virus-induced gene 2, also known as GPR183) was recently shown to be linked to autoimmune…”
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Oxysterols are agonist ligands of RORγt and drive Th17 cell differentiation by Soroosh, Pejman, Wu, Jiejun, Xue, Xiaohua, Song, Jiao, Sutton, Steven W., Sablad, Marciano, Yu, Jingxue, Nelen, Marina I., Liu, Xuejun, Castro, Glenda, Luna, Rosa, Crawford, Shelby, Banie, Homayon, Dandridge, Rose A., Deng, Xiaohu, Bittner, Anton, Kuei, Chester, Tootoonchi, Mandana, Rozenkrants, Natasha, Herman, Krystal, Gao, Jingjin, Yang, Xia V., Sachen, Kacey, Ngo, Karen, Fung-Leung, Wai-Ping, Nguyen, Steven, de Leon-Tabaldo, Aimee, Blevitt, Jonathan, Zhang, Yan, Cummings, Maxwell D., Rao, Tadimeti, Mani, Neelakandha S., Liu, Changlu, McKinnon, Murray, Milla, Marcos E., Fourie, Anne M., Sun, Siquan

“…The RAR-related orphan receptor gamma t (RORγt) is a nuclear receptor required for generating IL-17–producing CD4 ⁺ Th17 T cells, which are essential in host…”
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Facile Assembly of Fused Benzo[4,5]furo Heterocycles by Liu, Jing, Fitzgerald, Anne E, Mani, Neelakandha S

“…A concise synthesis of fused benzo[4,5]furo heterocycles 18 has been developed. Chemo/regioselective Suzuki coupling between 1,2-dihaloarene 17 and…”
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Gram-Scale Synthesis of a β‑Secretase 1 (BACE 1) Inhibitor by Allison, Brett D, Mani, Neelakandha S

“…Development of a scalable synthesis of an oxazine class of β-secretase inhibitor is described. Trifluoromethylated acyloin synthesis by the reaction of a…”
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Synthesis and Antitumor Activity of an Inhibitor of Fatty Acid Synthase by Kuhajda, Francis P., Pizer, Ellen S., Li, Ji Nong, Mani, Neelakandha S., Frehywot, Gojeb L., Townsend, Craig A.

“…Compared to normal human tissues, many common human cancers, including carcinoma of the colon, prostate, ovary, breast, and endometrium, express high levels of…”
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Reactions between Weinreb Amides and 2-Magnesiated Oxazoles:  A Simple and Efficient Preparation of 2-Acyl Oxazoles by Pippel, Daniel J, Mapes, Christopher M, Mani, Neelakandha S

“…Treatment of oxazole or 5-aryl oxazoles with i-PrMgCl smoothly generates the corresponding 2-Grignard reagents, which react with Weinreb amides to provide…”
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Discovery of 6-N,N-Bis(2,2,2-trifluoroethyl)amino- 4-trifluoromethylquinolin-2(1H)-one as a Novel Selective Androgen Receptor Modulator by van Oeveren, Arjan, Motamedi, Mehrnouch, Mani, Neelakandha S, Marschke, Keith B, López, Francisco J, Schrader, William T, Negro-Vilar, Andrés, Zhi, Lin

“…The androgen receptor is a member of the extended family of nuclear receptors and is widely distributed throughout the body. Androgen therapy is used to…”
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CuI-Catalyzed Amination of Arylhalides with Guanidines or Amidines: A Facile Synthesis of 1-H-2-Substituted Benzimidazoles by Deng, Xiaohu, McAllister, Heather, Mani, Neelakandha S

“…CuI/L5 (N,N′-dimethylethylenediamine) proves to be an efficient catalyst system for the amination of arylhalides with guanidines. The same catalyst system is…”
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Synthesis of 4-Arylpiperidines from 1-Benzyl-4-piperidone:  Application of the Shapiro Reaction and Alkenylsilane Cross-Coupling by Morrill, Christie, Mani, Neelakandha S

“…1-Benzyl-3,4-unsaturated-4-piperidinyl benzyldimethylsilane has been prepared and observed to readily undergo palladium-catalyzed cross-coupling reactions with…”
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Base-Mediated Reaction of Hydrazones and Nitroolefins with a Reversed Regioselectivity:  A Novel Synthesis of 1,3,4-Trisubstituted Pyrazoles by Deng, Xiaohu, Mani, Neelakandha S

“…A regioselective synthesis of 1,3,4-tri- or 1,3,4,5-tetrasubstituted pyrazoles by the reaction of hydrazones with nitroolefins is described. Mediated with…”
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Reaction of N-Monosubstituted Hydrazones with Nitroolefins:  A Novel Regioselective Pyrazole Synthesis by Deng, Xiaohu, Mani, Neelakandha S

“…A novel regioselective synthesis of substituted pyrazoles from N-monosubstituted hydrazones and nitroolefins is described. The reaction is performed in a…”
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Regioselective Electrophilic Fluorination of Rationally Designed Imidazole Derivatives by Albertshofer, Klaus, Mani, Neelakandha S

“…We report the regioselective and direct functionalization of rationally designed imidazole derivatives through electrophilic fluorination with…”
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A Step-Economical Route to Fused 1,2,3-Triazoles via an Intramolecular 1,3-Dipolar Cycloaddition between a Nitrile and an in Situ Generated Aryldiazomethane by Mani, Neelakandha S, Fitzgerald, Anne E

“…An intramolecular 1,3-dipolar cycloaddition strategy for rapid entry into triazole-fused heterocyclic compounds without recourse to the traditional…”
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Reactivity-Controlled Regioselectivity: A Regiospecific Synthesis of 1,2-Disubstituted Benzimidazoles by Deng, Xiaohu, Mani, Neelakandha S.

“…We demonstrate exceptional levels of regioselectivity in the tandem amination reactions between 1,2‐differentiated dihaloarenes and N‐substituted amidines. The…”
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The synthesis of 2-amino-4(3H)-quinazolinones and related heterocycles via a mild electrocyclization of aryl guanidines by Sales, Zachary S., Mani, Neelakandha S., Allison, Brett D.

“…[Display omitted] •Efficient synthesis of 2-aminoquinazolinones using carbonyl diimidazole.•The mild reaction conditions tolerate a variety of functional…”
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An Efficient Route to 4-Aryl-5-pyrimidinylimidazoles via Sequential Functionalization of 2,4-Dichloropyrimidine by Deng, Xiaohu, Mani, Neelakandha S

“…Starting from 2,4-dichloropyrimidine, a concise synthetic route to medicinally important 4-aryl-5-pyrimidinylimidazoles is described. Sequential substitution…”
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Allyl-Assisted, Cu(I)-Catalyzed Azide–Alkyne Cycloaddition/Allylation Reaction: Assembly of the [1,2,3]Triazolo-4,5,6,7-tetrahydropyridine Core Structure by Deng, Xiaohu, Liang, Jimmy, Allison, Brett B, Dvorak, Curt, McAllister, Heather, Savall, Brad M, Mani, Neelakandha S

“…We report a Cu­(I)-catalyzed azide–alkyne–allyl halide three-component reaction for a one-pot synthesis of 1,4-disubstituted 5-allyl-1,2,3-triazoles. The allyl…”
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Novel Octahydropyrrolo[3,4‑c]pyrroles Are Selective Orexin‑2 Antagonists: SAR Leading to a Clinical Candidate by Letavic, Michael A., Bonaventure, Pascal, Carruthers, Nicholas I., Dugovic, Christine, Koudriakova, Tatiana, Lord, Brian, Lovenberg, Timothy W., Ly, Kiev S., Mani, Neelakandha S., Nepomuceno, Diane, Pippel, Daniel J., Rizzolio, Michele, Shelton, Jonathan E., Shah, Chandra R., Shireman, Brock T., Young, Lana K., Yun, Sujin

“…The preclinical characterization of novel octahydro­pyrrolo­[3,4-c]­pyrroles that are potent and selective orexin-2 antagonists is described. Optimization of…”
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Fluoro analogs of bioactive oxy-sterols: Synthesis of an EBI2 agonist with enhanced metabolic stability by Deng, Xiaohu, Sun, Siquan, Wu, Jiejun, Kuei, Chester, Joseph, Victory, Liu, Changlu, Mani, Neelakandha S.

“…Synthesis of several 7-hydroxy oxysterols and their potential roles as signaling molecules in the innate and adaptive immune responses is discussed. Discovery…”
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