Search Results - "Manhas, Ashan"

Synthesis and in vitro SAR evaluation of natural vanillin-based chalcones tethered quinolines as antiplasmodial agents by Andhare, Nitin H., Anas, Mohammad, Rastogi, Sumit K., Manhas, Ashan, Thopate, Yogesh, Srivastava, Kumkum, Kumar, Niti, Sinha, Arun K.

“…A series of novel chalcone derivatives were synthesized and investigated against the chloroquine-sensitive P. falciparum 3D7 ( Pf 3D7) strain and…”
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Synthesis and Antimalarial Activity of 4‑Methylaminoquinoline Compounds against Drug-Resistant Parasite by Tiwari, Vinay Shankar, Joshi, Prince, Yadav, Kanchan, Sharma, Anamika, Chowdhury, Sushobhan, Manhas, Ashan, Kumar, Niti, Tripathi, Renu, Haq, Wahajul

“…A series of novel 4-aminoquinoline analogues bearing a methyl group at 4-aminoquinoline moiety were synthesized via a new and robust synthetic route comprising…”
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Synthesis, biological evaluation, Structure − Activity relationship studies of quinoline-imidazole derivatives as potent antimalarial agents by Roy, Deblina, Anas, Mohammad, Manhas, Ashan, Saha, Satyen, Kumar, Niti, Panda, Gautam

“…[Display omitted] •Quinoline − imidazole hybrids active against both CQ-sensitive and MDR strain in vitro.•Enantiomer (−)-11(xxxii) had potent antimalarial…”
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Evaluation of ethnopharmacologically selected Vitex negundo L. for In vitro antimalarial activity and secondary metabolite profiling by Dwivedi, Manish Kumar, Shukla, Ravindra, Sharma, Naveen Kumar, Manhas, Ashan, Srivastava, Kumkum, Kumar, Niti, Singh, Prashant Kumar

“…Limited drugs, rise in drug resistance against frontline anti-malarial drugs, non-availability of efficacious vaccines and high cost of drug development…”
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Synthesis, in vitro and in silico antimalarial activity of 7-chloroquinoline and 4H-chromene conjugates by Parthiban, A., Muthukumaran, J., Manhas, Ashan, Srivastava, Kumkum, Krishna, R., Rao, H. Surya Prakash

“…IC50 values: 7d: 0.62μM CQS strain & 1.78μM CQR strain and 15b: 0.29μM CQS strain & 0.496μM CQR strain. [Display omitted] A new series of…”
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Investigating Pharmacological Targeting of G‑Quadruplexes in the Human Malaria Parasite by Anas, Mohammad, Sharma, Richa, Dhamodharan, V, Pradeepkumar, P. I, Manhas, Ashan, Srivastava, Kumkum, Ahmed, Shakil, Kumar, Niti

“…The unique occurrence of G-quadruplexes in the AT-rich genome of human malaria parasite Plasmodium falciparum provides hints about their critical roles in…”
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Design, synthesis and antiplasmodial activity of novel imidazole derivatives based on 7-chloro-4-aminoquinoline by Kondaparla, Srinivasarao, Manhas, Ashan, Dola, Vasantha Rao, Srivastava, Kumkum, Puri, Sunil K., Katti, S.B.

“…[Display omitted] •Novel series of short chain 4-aminoquinoline-imidazole derivatives were designed and synthesized.•Assessment of 4-aminoquinolines for in…”
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Adenine Modification at C7 as a Viable Strategy to Potentiate the Antimalarial Activity of Quinolones by Kurian, Jais, Kumari, Varsha, Chaluvalappil, Saheer V., Anas, Mohammad, Manhas, Ashan, Kalluruttimmal, Ramshad, Kumar, Niti, Manheri, Muraleedharan K.

“…Although many quinolones have shown promise as potent antimalarials, their clinical development has been slow due to poor performance in vivo. Insights into…”
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Antimalarial activity and safety assessment of Flueggea virosa leaves and its major constituent with special emphasis on their mode of action by Singh, Shiv Vardan, Manhas, Ashan, Kumar, Yogesh, Mishra, Sonali, Shanker, Karuna, Khan, Feroz, Srivastava, Kumkum, Pal, Anirban

“…Abstract A clinical emergency stands due to the appearance of drug resistant Plasmodium strains necessitate novel and effective antimalarial chemotypes, where…”
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A phenolic glycoside from Flacourtia indica induces heme mediated oxidative stress in Plasmodium falciparum and attenuates malaria pathogenesis in mice by Singh, Shiv Vardan, Manhas, Ashan, Singh, Suriya P., Mishra, Sonali, Tiwari, Nimisha, Kumar, Parmanand, Shanker, Karuna, Srivastava, Kumkum, Sashidhara, Koneni V., Pal, Anirban

“…Flacourtia indica is especially popular among the various communities of many African countries where it is being used traditionally for the treatment of…”
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Antimalarial activity of novel 4-aminoquinolines active against drug resistant strains by Kondaparla, Srinivasarao, Soni, Awakash, Manhas, Ashan, Srivastava, Kumkum, Puri, Sunil K., Katti, S.B.

“…[Display omitted] •Novel side chain modified 4-aminoquinolines were designed and synthesized.•Assessment of 4-aminoquinolines for in vitro and in vivo…”
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