Search Results - "Mangrulkar, Shubhada"

Mitochondrial Dysfunction as a Signaling Target for Therapeutic Intervention in Major Neurodegenerative Disease by Mangrulkar, Shubhada V., Wankhede, Nitu L., Kale, Mayur B., Upaganlawar, Aman B., Taksande, Brijesh G., Umekar, Milind J., Anwer, Md. Khalid, Dailah, Hamad Ghaleb, Mohan, Syam, Behl, Tapan

“…Neurodegenerative diseases (NDD) are incurable and the most prevalent cognitive and motor disorders of elderly. Mitochondria are essential for a wide range of…”
Get full text

Decoding mitochondrial quality control mechanisms: Identifying treatment targets for enhanced cellular health by Wankhede, Nitu L., Rajendra Kopalli, Spandana, Dhokne, Mrunali D., Badnag, Dishant J., Chandurkar, Pranali A., Mangrulkar, Shubhada V., Shende, Prajwali V., Taksande, Brijesh G., Upaganlawar, Aman B., Umekar, Milind J., Koppula, Sushruta, Kale, Mayur B.

“…•Neuronal development, maturation, and function rely significantly on the essential metabolic functions of mitochondria.•Mitochondrial dysfunction, stemming…”
Get full text

Molecular understanding of ER-MT communication dysfunction during neurodegeneration by Sammeta, Shivkumar S., Banarase, Trupti A., Rahangdale, Sandip R., Wankhede, Nitu L., Aglawe, Manish M., Taksande, Brijesh G., Mangrulkar, Shubhada V., Upaganlawar, Aman B., Koppula, Sushruta, Kopalli, Spandana Rajendra, Umekar, Milind J., Kale, Mayur B.

“…[Display omitted] •Mitochondrial-ER contact sites (MERCS) have received considerable attention in the domain of cell homeostasis and dysfunction, specifically…”
Get full text

Nano-enabled delivery of diosgenin and emodin ameliorates respirable silica dust-induced pulmonary fibrosis silicosis in rats by Sherekar, Prasad, Suke, Sanvidhan G., Dhok, Archana, Harode, Raunak, Mangrulkar, Shubhada, Pingle, Shubhangi

“…Oxidative stress and inflammation play a fundamental role in the beginning and advancement of silicosis. Hence, questing active phytocompounds (APCs) with…”
Get full text

Comprehensive developmental investigation on simvastatin enriched bioactive film forming spray using the quality by design paradigm: a prospective strategy for improved wound healing by Patel, Vrushali N, Patel, Heta V, Agrawal, Kashish, Soni, Ishika, Shah, Pranav, Mangrulkar, Shubhada V, Umekar, Milind J, Lalan, Manisha S

“…The use of topical antimicrobials in wound healing presents challenges like risk of drug resistance and toxicity to local tissue. Simvastatin (SIM), a…”
Get full text

Nanoformulation, Characterization, and In Vivo Pharmacokinetic Studies of Diosgenin- and Emodin-Loaded Polymeric Nanoparticles by Sherekar, Prasad, Suke, Sanvidhan G., Dani, Ragini, Mangrulkar, Shubhada, Dhok, Archana

“…Obstruct pharmacokinetics and low bioavailability of diosgenin (DG) and emodin (ED) are major limitations for their therapeutic success in several inflammatory…”
Get full text

Recent Perspectives on Cardiovascular Toxicity Associated with Colorectal Cancer Drug Therapy by Kashyap, Monu Kumar, Mangrulkar, Shubhada V, Kushwaha, Sapana, Ved, Akash, Kale, Mayur B, Wankhede, Nitu L, Taksande, Brijesh G, Upaganlawar, Aman B, Umekar, Milind J, Koppula, Sushruta, Kopalli, Spandana Rajendra

“…Cardiotoxicity is a well-known adverse effect of cancer-related therapy that has a significant influence on patient outcomes and quality of life. The use of…”
Get full text

Mitophagy regulation in aging and neurodegenerative disease by Banarase, Trupti A., Sammeta, Shivkumar S., Wankhede, Nitu L., Mangrulkar, Shubhada V., Rahangdale, Sandip R., Aglawe, Manish M., Taksande, Brijesh G., Upaganlawar, Aman B., Umekar, Milind J., Kale, Mayur B.

“…Mitochondria are the primary cellular energy generators, supplying the majority of adenosine triphosphate through oxidative phosphorylation, which is necessary…”
Get full text

Phytophospholipid Complex of Caffeic Acid: Development, In vitro Characterization, and In Vivo Investigation of Antihyperlipidemic and Hepatoprotective Action in Rats by Mangrulkar, Shubhada, Shah, Pranav, Navnage, Sonali, Mazumdar, Priyanka, Chaple, Dinesh

“…Caffeic acid (CA), a hydroxycinnamic acid possessing a variety of pharmacological activities, has caused a growing interest for the treatment of hyperlipidemia…”
Get full text

Polymeric nanofibers derived therapeutic approach for skeletal muscle regeneration: The promising future of muscle repair by Nathani, Khushali, Damani, Mansi, Mangrulkar, Shubhada, Sawarkar, Sujata

“…Volumetric muscle loss (VML) represents a condition characterized by skeletal muscle injury inflicted due to trauma or surgery. In severe conditions, it leads…”
Get full text

Influence of Microgravity on Cerebrovascular Complications: Exploring Molecular Manifestation and Promising Countermeasures by Neje, Pankaj, Taksande, Brijesh, Umekar, Milind, Mangrulkar, Shubhada

“…With NASA and other space agencies planning for longer-duration spaceflights, such as missions to Mars, and the rise in space tourism, it is crucial to…”
Get full text

Thermosensitive in-situ gel of Nifedipine: A strategy to offset cognition impairment in Alzheimer's disease by Dighe, Sayali, Lonkar, Sarika, Jog, Sunil, Mangrulkar, Shubhada V., Sawarkar, Sujata P.

“…Increased intracellular Ca2+ accumulation plays a pivotal role in the development and progression of Alzheimer's disease (AD). Thus, utilization of calcium…”
Get full text

Rosuvastatin-loaded solid SMEDDS: an innovative approach for solubility augmentation and improved pharmacodynamic profile by Bakhle, Suparna, Biswas, Reetuparna, Upadhye, Kanchan, Dixit, Gouri, Mangrulkar, Shubhada, Shah, Pranav

Get full text

Amalgamation of Solid Dispersion and Melt Adsorption Technique: Improved In Vitro and In Vivo Performance of Ticagrelor Tablets by Yadav, Mukesh, Sarolia, Jayant, Vyas, Bhavin, Lalan, Manisha, Mangrulkar, Shubhada, Shah, Pranav

“…Ticagrelor (TG) suffers from low peroral bioabsorption (36%) due to P-gp efflux and poor solubility (10 µg/mL). TG solid dispersion adsorbates (TG-SDAs) were…”
Get full text

Azilsartan prevents muscle loss and fast- to slow-twitch muscle fiber shift in natural ageing sarcopenic rats by Prajapati, Priyanka, Kumar, Anand, Mangrulkar, Shubhada, Chaple, D R, Saraf, Shubhini A, Kushwaha, Sapana

“…Sarcopenia is a musculoskeletal disease that reduces muscle mass and strength in older individuals. The study investigates the effects of azilsartan (AZL) on…”
Get more information

Chronic agmatine treatment prevents olanzapine-induced obesity and metabolic dysregulation in female rats by Dixit, Madhura P., Sammeta, Shivkumar S., Dhokne, Mrunali D., Mangrulkar, Shubhada, Upadhya, Manoj A., Umekar, Milind J., Taksande, Brijesh G., Kotagale, Nandkishor R.

“…Antipsychotic-induced obesity affects millions of people and is a serious health condition worldwide. Olanzapine is the most widely prescribed antipsychotic…”
Get full text