Search Results - "Mangieri, Leandra R"
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Identification of a neurocircuit underlying regulation of feeding by stress-related emotional responses
Published in Nature communications (01-08-2019)“…Feeding is known to be profoundly affected by stress-related emotional states and eating disorders are comorbid with psychiatric symptoms and altered emotional…”
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GABAergic projections from lateral hypothalamus to paraventricular hypothalamic nucleus promote feeding
Published in The Journal of neuroscience (25-02-2015)“…Lesions of the lateral hypothalamus (LH) cause hypophagia. However, activation of glutamatergic neurons in LH inhibits feeding. These results suggest a…”
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A neural basis for antagonistic control of feeding and compulsive behaviors
Published in Nature communications (04-01-2018)“…Abnormal feeding often co-exists with compulsive behaviors, but the underlying neural basis remains unknown. Excessive self-grooming in rodents is associated…”
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ATP6V0C knockdown in neuroblastoma cells alters autophagy-lysosome pathway function and metabolism of proteins that accumulate in neurodegenerative disease
Published in PloS one (01-04-2014)“…ATP6V0C is the bafilomycin A1-binding subunit of vacuolar ATPase, an enzyme complex that critically regulates vesicular acidification. We and others have shown…”
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Rotenone Inhibits Autophagic Flux Prior to Inducing Cell Death
Published in ACS chemical neuroscience (19-12-2012)“…Rotenone, which selectively inhibits mitochondrial complex I, induces oxidative stress, α-synuclein accumulation, and dopaminergic neuron death, principal…”
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A lateral hypothalamus to basal forebrain neurocircuit promotes feeding by suppressing responses to anxiogenic environmental cues
Published in Science advances (01-03-2019)“…Animals must consider competing information before deciding to eat: internal signals indicating the desirability of food and external signals indicating the…”
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MHCII is required for α-synuclein-induced activation of microglia, CD4 T cell proliferation, and dopaminergic neurodegeneration
Published in The Journal of neuroscience (05-06-2013)“…Accumulation of α-synuclein (α-syn) in the brain is a core feature of Parkinson disease (PD) and leads to microglial activation, production of inflammatory…”
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Hypothalamic Non-AgRP, Non-POMC GABAergic Neurons Are Required for Postweaning Feeding and NPY Hyperphagia
Published in The Journal of neuroscience (22-07-2015)“…The hypothalamus is critical for feeding and body weight regulation. Prevailing studies focus on hypothalamic neurons that are defined by selectively…”
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Red blood cell β-adrenergic receptors contribute to diet-induced energy expenditure by increasing O2 supply
Published in JCI insight (20-07-2017)“…Diet-induced obesity (DIO) represents the major cause for the current obesity epidemic, but the mechanism underlying DIO is unclear. β-Adrenergic receptors…”
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Defensive Behaviors Driven by a Hypothalamic-Ventral Midbrain Circuit
Published in eNeuro (01-07-2019)“…The paraventricular hypothalamus (PVH) regulates stress, feeding behaviors and other homeostatic processes, but whether PVH also drives defensive states…”
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VMAT2-Mediated Neurotransmission from Midbrain Leptin Receptor Neurons in Feeding Regulation
Published in eNeuro (01-05-2017)“…Leptin receptors (LepRs) expressed in the midbrain contribute to the action of leptin on feeding regulation. The midbrain neurons release a variety of…”
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ATP6V0C Knockdown in Neuroblastoma Cells Alters Autophagy-Lysosome Pathway Function and Metabolism of Proteins that Accumulate in Neurodegenerative Disease: e93257
Published in PloS one (01-04-2014)“…ATP6V0C is the bafilomycin A1-binding subunit of vacuolar ATPase, an enzyme complex that critically regulates vesicular acidification. We and others have shown…”
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Journal Article