Search Results - "Mangeot, Philippe E"

Loop extrusion as a mechanism for formation of DNA damage repair foci by Arnould, Coline, Rocher, Vincent, Finoux, Anne-Laure, Clouaire, Thomas, Li, Kevin, Zhou, Felix, Caron, Pierre, Mangeot, Philippe. E., Ricci, Emiliano P., Mourad, Raphaël, Haber, James E., Noordermeer, Daan, Legube, Gaëlle

“…The repair of DNA double-strand breaks (DSBs) is essential for safeguarding genome integrity. When a DSB forms, the PI3K-related ATM kinase rapidly triggers…”
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Genome editing in primary cells and in vivo using viral-derived Nanoblades loaded with Cas9-sgRNA ribonucleoproteins by Mangeot, Philippe E., Risson, Valérie, Fusil, Floriane, Marnef, Aline, Laurent, Emilie, Blin, Juliana, Mournetas, Virginie, Massouridès, Emmanuelle, Sohier, Thibault J. M., Corbin, Antoine, Aubé, Fabien, Teixeira, Marie, Pinset, Christian, Schaeffer, Laurent, Legube, Gaëlle, Cosset, François-Loïc, Verhoeyen, Els, Ohlmann, Théophile, Ricci, Emiliano P.

“…Programmable nucleases have enabled rapid and accessible genome engineering in eukaryotic cells and living organisms. However, their delivery into target cells…”
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A cohesin/HUSH- and LINC-dependent pathway controls ribosomal DNA double-strand break repair by Marnef, Aline, Finoux, Anne-Laure, Arnould, Coline, Guillou, Emmanuelle, Daburon, Virginie, Rocher, Vincent, Mangeat, Thomas, Mangeot, Philippe E, Ricci, Emiliano P, Legube, Gaëlle

“…The ribosomal DNA (rDNA) represents a particularly unstable locus undergoing frequent breakage. DNA double-strand breaks (DSBs) within rDNA induce both rDNA…”
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A homozygous mutation in the human selenocysteine tRNA gene impairs UGA recoding activity and selenoproteome regulation by selenium by Vindry, Caroline, Guillin, Olivia, Wolff, Philippe, Marie, Paul, Mortreux, Franck, Mangeot, Philippe E, Ohlmann, Théophile, Chavatte, Laurent

“…Abstract The selenocysteine (Sec) tRNA (tRNA[Ser]Sec) governs Sec insertion into selenoproteins by the recoding of a UGA codon, typically used as a stop codon…”
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IRGM is a common target of RNA viruses that subvert the autophagy network by Grégoire, Isabel Pombo, Richetta, Clémence, Meyniel-Schicklin, Laurène, Borel, Sophie, Pradezynski, Fabrine, Diaz, Olivier, Deloire, Alexandre, Azocar, Olga, Baguet, Joël, Le Breton, Marc, Mangeot, Philippe E, Navratil, Vincent, Joubert, Pierre-Emmanuel, Flacher, Monique, Vidalain, Pierre-Olivier, André, Patrice, Lotteau, Vincent, Biard-Piechaczyk, Martine, Rabourdin-Combe, Chantal, Faure, Mathias

“…Autophagy is a conserved degradative pathway used as a host defense mechanism against intracellular pathogens. However, several viruses can evade or subvert…”
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Generation and Comprehensive Analysis of an Influenza Virus Polymerase Cellular Interaction Network by TAFFOREAU, Lionel, CHANTIER, Thibault, PRADEZYNSKI, Fabrine, PELLET, Johann, MANGEOT, Philippe E, VIDALAIN, Pierre-Olivier, ANDRE, Patrice, RABOURDIN-COMBE, Chantal, LOTTEAU, Vincent

“…OA  Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+…”
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Baboon Envelope Pseudotyped “Nanoblades” Carrying Cas9/gRNA Complexes Allow Efficient Genome Editing in Human T, B, and CD34+ Cells and Knock-in of AAV6-Encoded Donor DNA in CD34+ Cells by Gutierrez-Guerrero, Alejandra, Abrey Recalde, Maria Jimena, Mangeot, Philippe E., Costa, Caroline, Bernadin, Ornellie, Périan, Séverine, Fusil, Floriane, Froment, Gisèle, Martinez-Turtos, Adriana, Krug, Adrien, Martin, Francisco, Benabdellah, Karim, Ricci, Emiliano P., Giovannozzi, Simone, Gijsbers, Rik, Ayuso, Eduard, Cosset, François-Loïc, Verhoeyen, Els

“…Programmable nucleases have enabled rapid and accessible genome engineering in eukaryotic cells and living organisms. However, their delivery into human blood…”
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A Versatile Strategy to Reduce UGA-Selenocysteine Recoding Efficiency of the Ribosome Using CRISPR-Cas9-Viral-Like-Particles Targeting Selenocysteine-tRNA [Ser]Sec Gene by Vindry, Caroline, Guillin, Olivia, Mangeot, Philippe E, Ohlmann, Théophile, Chavatte, Laurent

“…The translation of selenoprotein mRNAs involves a non-canonical ribosomal event in which an in-frame UGA is recoded as a selenocysteine (Sec) codon instead of…”
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Viruses traverse the human proteome through peptide interfaces that can be biomimetically leveraged for drug discovery by Meyniel-Schicklin, Laurène, Amaudrut, Jérôme, Mallinjoud, Pierre, Guillier, Fabrice, Mangeot, Philippe E, Lines, Laetitia, Aublin-Gex, Anne, Scholtes, Caroline, Punginelli, Claire, Joly, Stéphane, Vasseur, Florence, Manet, Evelyne, Gruffat, Henri, Henry, Thomas, Halitim, Farès, Paparin, Jean-Laurent, Machin, Peter, Darteil, Raphaël, Sampson, Diane, Mikaelian, Ivan, Lane, Lydie, Navratil, Vincent, Golinelli-Cohen, Marie-Pierre, Terzi, Fabiola, André, Patrice, Lotteau, Vincent, Vonderscher, Jacky, Meldrum, Eric C, de Chassey, Benoit

“…We present a drug design strategy based on structural knowledge of protein-protein interfaces selected through virus-host coevolution and translated into…”
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A prime-boost strategy using virus-like particles pseudotyped for HCV proteins triggers broadly neutralizing antibodies in macaques by Garrone, Pierre, Fluckiger, Anne-Catherine, Mangeot, Philippe E, Gauthier, Emmanuel, Dupeyrot-Lacas, Pia, Mancip, Jimmy, Cangialosi, Arnaud, Du Chéné, Isaure, LeGrand, Roger, Mangeot, Isabelle, Lavillette, Dimitri, Bellier, Bertrand, Cosset, François-Loic, Tangy, Frederic, Klatzmann, David, Dalba, Charlotte

“…Chronic hepatitis C virus (HCV) infection, with its cohort of life-threatening complications, affects more than 200 million persons worldwide and has a…”
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Delivery of the Cas9/sgRNA Ribonucleoprotein Complex in Immortalized and Primary Cells via Virus-like Particles ("Nanoblades") by Mangeot, Philippe E, Guiguettaz, Laura, Sohier, Thibault J M, Ricci, Emiliano P

“…The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas system has democratized genome-editing in eukaryotic cells and led to the…”
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Nanoblades allow high-level genome editing in murine and human organoids by Tiroille, Victor, Krug, Adrien, Bokobza, Emma, Kahi, Michel, Bulcaen, Mattijs, Ensinck, Marjolein M., Geurts, Maarten H., Hendriks, Delilah, Vermeulen, François, Larbret, Frédéric, Gutierrez-Guerrero, Alejandra, Chen, Yu, Van Zundert, Indra, Rocha, Susana, Rios, Anne C., Medaer, Louise, Gijsbers, Rik, Mangeot, Philippe E., Clevers, Hans, Carlon, Marianne S., Bost, Frédéric, Verhoeyen, Els

“…Genome engineering has become more accessible thanks to the CRISPR-Cas9 gene-editing system. However, using this technology in synthetic organs called…”
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Nanoblades: Pseudoviral shuttles for CRISPR-CAS9 delivery by Mangeot, Philippe E

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Loop extrusion as a mechanism for DNA damage repair foci formation by Arnould, Coline, Rocher, Vincent, Finoux, Anne-Laure, Clouaire, Thomas, Li, Kevin, Zhou, Felix, Caron, Pierre, Mangeot, Philippe. E., Ricci, Emiliano P., Mourad, Raphael, Haber, James E, Noordermeer, Daan, Legube, Gaëlle

“…DNA Double-Strand Break (DSB) repair is essential to safeguard genome integrity. Upon DSBs, the ATM PI3K kinase rapidly triggers the establishment of…”
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