Search Results - "Mangelsdorf, DJ"

LXRS and FXR: the yin and yang of cholesterol and fat metabolism by Kalaany, Nada Y, Mangelsdorf, David J

“…Liver X receptors (LXRs) and farnesoid X receptor (FXR) are nuclear receptors that function as intracellular sensors for sterols and bile acids, respectively…”
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Liver X Receptor Signaling Pathways in Cardiovascular Disease by Tontonoz, Peter, Mangelsdorf, David J

“…The liver X receptors α and β (LXRα and LXRβ) are members of the nuclear receptor family of proteins that are critical for the control of lipid homeostasis in…”
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Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c by Watanabe, Mitsuhiro, Houten, Sander M., Wang, Li, Moschetta, Antonio, Mangelsdorf, David J., Heyman, Richard A., Moore, David D., Auwerx, Johan

“…We explored the effects of bile acids on triglyceride (TG) homeostasis using a combination of molecular, cellular, and animal models. Cholic acid (CA) prevents…”
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Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis by Inagaki, Takeshi, Choi, Mihwa, Moschetta, Antonio, Peng, Li, Cummins, Carolyn L., McDonald, Jeffrey G., Luo, Guizhen, Jones, Stacey A., Goodwin, Bryan, Richardson, James A., Gerard, Robert D., Repa, Joyce J., Mangelsdorf, David J., Kliewer, Steven A.

“…The liver and intestine play crucial roles in maintaining bile acid homeostasis. Here, we demonstrate that fibroblast growth factor 15 (FGF15) signals from…”
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Regulation of Antibacterial Defense in the Small Intestine by the Nuclear Bile Acid Receptor by Inagaki, Takeshi, Moschettat, Antonio, Lee, Youn-Kyoung, Peng, Li, Zhao, Guixiang, Downes, Michael, Yu, Ruth T., Shelton, John M., Richardson, James A., Repa, Joyce J., Mangelsdorf, David J., Kliewer, Steven A.

“…Obstruction of bile flow results in bacterial proliferation and mucosal injury in the small intestine that can lead to the translocation of bacteria across the…”
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Reciprocal regulation of inflammation and lipid metabolism by liver X receptors by Tontonoz, Peter, Joseph, Sean B, Castrillo, Antonio, Laffitte, Bryan A, Mangelsdorf, David J

“…Macrophages have important roles in both lipid metabolism and inflammation and are central to the pathogenesis of atherosclerosis. The liver X receptors (LXRs)…”
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Prevention of cholesterol gallstone disease by FXR agonists in a mouse model by Mangelsdorf, David J, Moschetta, Antonio, Bookout, Angie L

“…Cholesterol gallstone disease is characterized by several events, including cholesterol precipitation in bile, increased bile salt hydrophobicity and…”
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De-orphanization of Cytochrome P450 2R1: A Microsomal Vitamin D 25-Hydroxylase by Cheng, J B, Motola, D L, Mangelsdorf, D J, Russell, D W

“…The conversion of vitamin D into an active ligand for the vitamin D receptor requires 25-hydroxylation in the liver and 1 alpha -hydroxylation in the kidney…”
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Genetic Evidence That the Human CYP2R1 Enzyme Is a Key Vitamin D 25-Hydroxylase by Cheng, Jeffrey B., Levine, Michael A., Bell, Norman H., Mangelsdorf, David J., Russell, David W., Wilson, Jean D.

“…The synthesis of bioactive vitamin D requires hydroxylation at the 1α and 25 positions by cytochrome P450 enzymes in the kidney and liver, respectively. The…”
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Identification of Ligands for DAF-12 that Govern Dauer Formation and Reproduction in C. elegans by Motola, Daniel L., Cummins, Carolyn L., Rottiers, Veerle, Sharma, Kamalesh K., Li, Tingting, Li, Yong, Suino-Powell, Kelly, Xu, H. Eric, Auchus, Richard J., Antebi, Adam, Mangelsdorf, David J.

“…In response to environmental and dietary cues, the C. elegans orphan nuclear receptor, DAF-12, regulates dauer diapause, reproductive development, fat…”
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Structural Determinants of Allosteric Ligand Activation in RXR Heterodimers by Shulman, Andrew I, Larson, Christopher, Mangelsdorf, David J, Ranganathan, Rama

“…Allosteric communication underlies ligand-dependent transcriptional responses mediated by nuclear receptors. While studies have elucidated many of the…”
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Nuclear Receptors and Lipid Physiology: Opening the X-Files by Chawla, Ajay, Repa, Joyce J., Evans, Ronald M., Mangelsdorf, David J.

“…Cholesterol, fatty acids, fat-soluble vitamins, and other lipids present in our diets are not only nutritionally important but serve as precursors for ligands…”
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Regulation of ATP-binding Cassette Sterol Transporters ABCG5 and ABCG8 by the Liver X Receptors α and β by Repa, Joyce J., Berge, Knut E., Pomajzl, Chris, Richardson, James A., Hobbs, Helen, Mangelsdorf, David J.

“…Mutations in the ATP-binding cassette (ABC) transporters ABCG5 and ABCG8 have recently been shown to cause the autosomal recessive disorder sitosterolemia…”
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The liver X receptor gene team: Potential new players in atherosclerosis by Mangelsdorf, David J, Repa, Joyce J

“…Liver X receptors (LXRs) are sterol-responsive transcription factors that regulate expression of genes involved in cholesterol matabolism and homeostasis…”
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The RXR heterodimers and orphan receptors by Mangelsdorf, David J., Evans, Ronald M.

“…The nuclear receptor superfamily is comprised of over 150 different proteins that have evolved to mediate a complex array of extracellular signals into…”
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A role for the apoptosis inhibitory factor AIM/Spα/Api6 in atherosclerosis development by Arai, Satoko, Shelton, John M., Chen, Mingyi, Bradley, Michelle N., Castrillo, Antonio, Bookout, Angie L., Mak, Puiying A., Edwards, Peter A., Mangelsdorf, David J., Tontonoz, Peter, Miyazaki, Toru

“…Macrophages play a central role in the development of atherosclerosis through the accumulation of oxidized LDL (oxLDL). AIM (Spα/Api6) has previously been…”
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Vitamin D Receptor as an Intestinal Bile Acid Sensor by Makishima, Makoto, Lu, Timothy T., Xie, Wen, Whitfield, G. Kerr, Domoto, Hideharu, Evans, Ronald M., Haussler, Mark R., Mangelsdorf, David J.

“…The vitamin D receptor (VDR) mediates the effects of the calcemic hormone 1α,25-dihydroxyvitamin D3[1,25(OH)2D 3]. We show that VDR also functions as a…”
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Human Bile Salt Export Pump Promoter Is Transactivated by the Farnesoid X Receptor/Bile Acid Receptor by Ananthanarayanan, M, Balasubramanian, N, Makishima, M, Mangelsdorf, D J, Suchy, F J

“…The bile salt excretory pump (BSEP, ABCb11) is critical for ATP-dependent transport of bile acids across the hepatocyte canalicular membrane and for generation…”
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Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ by Repa, Joyce J., Liang, Guosheng, Ou, Jiafu, Bashmakov, Yuriy, Lobaccaro, Jean-Marc A., Shimomura, Iichiro, Shan, Bei, Brown, Michael S., Goldstein, Joseph L., Mangelsdorf, David J.

“…The liver X receptors (LXRs) are members of the nuclear hormone receptor superfamily that are bound and activated by oxysterols. These receptors serve as…”
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A Nuclear Receptor Atlas: 3T3-L1 Adipogenesis by Fu, Mingui, Sun, Tingwan, Bookout, Angie L, Downes, Michael, Yu, Ruth T, Evans, Ronald M, Mangelsdorf, David J

“…The differentiation of a preadipocyte into a mature adipocyte represents a fundamental process in biology that requires a scripted program of transcriptional…”
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