Search Results - "Mangelsdorf, D.J."

Liver X receptors and cholesterol homoeostasis: spotlight on the adrenal gland by Cummins, C L, Mangelsdorf, D J

“…The LXRs (liver X receptors) (LXRalpha and LXRbeta) are nuclear hormone receptors that are activated by oxysterols, endogenous oxidative metabolites of…”
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Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages: a transcriptional role for specific oxysterols by Venkateswaran, A, Repa, J.J, Lobaccaro, J.M.A, Bronson, A, Mangelsdorf, D.J, Edwards, P.A

“…To identify genes that are transcriptionally activated when human macrophages accumulate excess lipids, we employed the mRNA differential display technique…”
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PPARα Is Necessary for the Lipopenic Action of Hyperleptinemia on White Adipose and Liver Tissue by Lee, Y., Yu, X., Gonzales, F., Mangelsdorf, D.J., Wang, May-Yun, Richardson, C., Witters, L.A., Unger, R.H.

“…Adenovirus-induced hyperleptinemia causes rapid disappearance of body fat in normal rats, presumably by up-regulating fatty acid oxidation within white…”
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Vitamin A receptors by Mangelsdorf, D J

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Cloning and Expression of Full-Length cDNA Encoding Human Vitamin D Receptor by Baker, Andrew R., McDonnell, Donald P., Hughes, Mark, Crisp, Tracey M., Mangelsdorf, David J., Haussler, Mark R., Pike, J. Wesley, Shine, John, O'Malley, Bert W.

“…Complementary DNA clones encoding the human vitamin D receptor have been isolated from human intestine and T47D cell cDNA libraries. The nucleotide sequence of…”
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Inhibition of growth and cholesterol synthesis in breast cancer cells by oxidation products of β-carotene by Hu, Xiaoming, White, Kevin M., Jacobsen, Neil E., Mangelsdorf, David J., Canfield, Louise M.

“…We have isolated and chemically characterized a polar oxidation product of β-carotene and tested the effect of a highly enriched fraction containing this…”
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1,25-dihydroxyvitamin D3-induced differentiation in a human promyelocytic leukemia cell line (HL-60): receptor-mediated maturation to macrophage-like cells by Mangelsdorf, D.J, Koeffler, H.P, Donaldson, C.A, Pike, J.W, Haussler, M.R

“…The human-derived promyelocytic leukemia cell line, HL-60, is known to differentiate into mature myeloid cells in the presence of 1,25-dihydroxyvitamin…”
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Chromosomal localization of the human retinoid X receptors by Almasan, A, Mangelsdorf, D J, Ong, E S, Wahl, G M, Evans, R M

“…The recently described retinoid X receptors (RXRs) respond to the novel retinoid 9-cis-retinoic acid and also serve as heterodimeric partners for the vitamin…”
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Avian and mammalian receptors for 1,25-dihydroxyvitamin D3: In vitro translation to characterize size and hormone-dependent regulation by Mangelsdorf, D.J, Pike, J.W, Haussler, M.R

“…In vitro translation of cellular poly(A)+ RNA coupled with immunoprecipitation was developed as a technique for characterizing 1,25-dihydroxyvitamin D3…”
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Immunoselection of cDNAs to avian intestinal calcium binding protein 28K and a novel calmodulin-like protein: assessment of mRNA regulation by the vitamin D hormone by Mangelsdorf, David J, Komm, Barry S, McDonnell, Donald P, Pike, J. Wesley, Haussler, Mark R

“…Calcium's role in a variety of cellular processes has been well documented. The storage, distribution, and delivery of calcium are regulated by a family of…”
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3P-0714 Establishment of a monoclonal antibody for human LXRα: Detection of LXRα protein expression in human macrophages by Watanabe, Y., Tanaka, T., Uchiyama, Y., Takeno, T., Izumi, A., Yamashita, H., Kumakura, J., Iwanari, H., Shu-Ying, J., Naito, M., Mangelsdorf, D.J., Hamakubo, T., Kodama, T.

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1,25-Dihydroxyvitamin D3 receptors: altered functional domains are associated with cellular resistance to vitamin D3 by Pike, J W, Allegretto, E A, Kelly, M A, Donaldson, C A, Marion, S L, Mangelsdorf, D J, Haussler, M R

“…1,25-Dihydroxyvitamin D3 receptors are cytosoluble proteins detectable in a variety of tissues responsive to 1,25(OH)2D3. They are DNA binding-proteins…”
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