Search Results - "Mangelsdorf, D. J."

Regulation of Absorption and ABC1-Mediated Efflux of Cholesterol by RXR Heterodimers by Repa, J. J., Turley, S. D., J.-M. A. Lobaccaro, Medina, J., Li, L., Lustig, K., Shan, B., Heyman, R. A., Dietschy, J. M., Mangelsdorf, D. J.

“…Several nuclear hormone receptors involved in lipid metabolism form obligate heterodimers with retinoid X receptors (RXRs) and are activated by RXR agonists…”
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Nuclear Receptors and Lipid Physiology: Opening the X-Files by Chawla, Ajay, Repa, Joyce J., Evans, Ronald M., Mangelsdorf, David J.

“…Cholesterol, fatty acids, fat-soluble vitamins, and other lipids present in our diets are not only nutritionally important but serve as precursors for ligands…”
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An oxysterol signalling pathway mediated by the nuclear receptor LXRα by Janowski, Bethany A, Willy, Patricia J, Devi, Thota Rama, Falck, J. R, Mangelsdorf, David J

“…Cholesterol and its oxysterol congeners are important constituents of cell membranes and function as intermediates in several crucial biosynthetic pathways…”
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THE ROLE OF ORPHAN NUCLEAR RECEPTORS IN THE REGULATION OF CHOLESTEROL HOMEOSTASIS by Repa, Joyce J, Mangelsdorf, David J

“…Cholesterol balance is maintained by a series of regulatory pathways that control the acquisition of cholesterol from endogenous and exogenous sources and the…”
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PPARα Is Necessary for the Lipopenic Action of Hyperleptinemia on White Adipose and Liver Tissue by Lee, Y., Yu, X., Gonzales, F., Mangelsdorf, D.J., Wang, May-Yun, Richardson, C., Witters, L.A., Unger, R.H.

“…Adenovirus-induced hyperleptinemia causes rapid disappearance of body fat in normal rats, presumably by up-regulating fatty acid oxidation within white…”
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Identification of a Nuclear Receptor for Bile Acids by Makishima, Makoto, Okamoto, Arthur Y., Repa, Joyce J., Tu, Hua, Learned, R. Marc, Luk, Alvin, Hull, Mitchell V., Lustig, Kevin D., Mangelsdorf, David J., Shan, Bei

“…Bile acids are essential for the solubilization and transport of dietary lipids and are the major products of cholesterol catabolism. Results presented here…”
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Differential Expression and Activation of a Family of Murine Peroxisome Proliferator-Activated Receptors by Kliewer, S. A., Forman, B. M., Blumberg, B., Ong, E. S., Borgmeyer, U., Mangelsdorf, D. J., Umesono, K., Evans, R. M.

“…To gain insight into the function of peroxisome proliferator-activated receptor (PPAR) isoforms in mammals, we have cloned and characterized two PPARα-related…”
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Roles of FGF19 in liver metabolism by Kir, S, Kliewer, S A, Mangelsdorf, D J

“…Fibroblast growth factor 19 (FGF19) is an ileum-derived postprandial enterokine that governs bile acid and nutrient metabolism. Synthesis of FGF19 is…”
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Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling by KLIEWER, S. A, UMESONO, K, MANGELSDORF, D. J, EVANS, R. M

“…Cellular responsiveness to retinoic acid and its metabolites is conferred through two structurally and pharmacologically distinct families of receptors: the…”
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Retinoid X Receptor-COUP-TF Interactions Modulate Retinoic Acid Signaling by Kliewer, Steven A., Umesono, Kazuhiko, Heyman, Richard A., Mangelsdorf, David J., Dyck, Jacqueline A., Evans, Ronald M.

“…We have recently described the properties of direct repeats (DRs) of the half-site AGGTCA as hormone response elements (HREs). According to our results,…”
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Nuclear oxysterol receptors, LXRs, are involved in the maintenance of mouse caput epididymidis structure and functions by Frenoux, J-M, Vernet, P, Volle, D H, Britan, A, Saez, F, Kocer, A, Henry-Berger, J, Mangelsdorf, D J, Lobaccaro, J-M A, Drevet, J R

“…In this study we looked at the epididymides and spermatozoa of mice knocked-out for nuclear oxysterol receptors (LXR). We have shown that LXR-deficient mice…”
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Nuclear receptor that identifies a novel retinoic acid response pathway by Mangelsdorf, David J, Ong, Estelita S, Dyck, Jacqueline A, Evans, Ronald M

“…Molecular cloning and transcriptional activation studies have revealed a new protein similar to the steroid hormone receptors and which responds specifically…”
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Cloning and Expression of Full-Length cDNA Encoding Human Vitamin D Receptor by Baker, Andrew R., McDonnell, Donald P., Hughes, Mark, Crisp, Tracey M., Mangelsdorf, David J., Haussler, Mark R., Pike, J. Wesley, Shine, John, O'Malley, Bert W.

“…Complementary DNA clones encoding the human vitamin D receptor have been isolated from human intestine and T47D cell cDNA libraries. The nucleotide sequence of…”
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Activation of mammalian retinoid X receptors by the insect growth regulator methoprene by Harmon, M A, Boehm, M F, Heyman, R A, Mangelsdorf, D J

“…We report that methoprene and its derivatives can stimulate gene transcription in vertebrates by acting through the retinoic acid-responsive transcription…”
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Identification and regulation of 1,25-dihydroxyvitamin D3 receptor activity and biosynthesis of 1,25-dihydroxyvitamin D3: studies in cultured bovine aortic endothelial cells and human dermal capillaries by MERKE, J, MILDE, P, LEWICKA, S, HÜGEL, U, KLAUS, G, MANGELSDORF, D. J, HAUSSLER, M. R, RAUTERBERG, E. W, RITZ, E

“…Because 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) has been shown to play roles in both proliferation and differentiation of novel target cells, the potential…”
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A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR by Mangelsdorf, D J, Umesono, K, Kliewer, S A, Borgmeyer, U, Ong, E S, Evans, R M

“…The vitamin A derivative retinoic acid exerts its effects on transcription through two distinct classes of nuclear receptors, the retinoic acid receptor (RAR)…”
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Oxysterols Induce Differentiation in Human Keratinocytes and Increase Ap-1-Dependent Involucrin Transcription by Hanley, Karen, Ng, Dean C., He, ShanShan, Lau, Peggy, Min, Katherine, Elias, Peter M., Bikle, Daniel D., Mangelsdorf, David J., Williams, Mary L., Feingold, Kenneth R.

“…Ligands and activators of the nuclear hormone receptor superfamily are important in the regulation of epidermal development and differentiation. Previously, we…”
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Reciprocal regulation of inflammation and lipid metabolism by liver X receptors by Tontonoz, Peter, Joseph, Sean B, Castrillo, Antonio, Laffitte, Bryan A, Mangelsdorf, David J

“…Macrophages have important roles in both lipid metabolism and inflammation and are central to the pathogenesis of atherosclerosis. The liver X receptors (LXRs)…”
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Vitamin A receptors by Mangelsdorf, D J

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Prevention of cholesterol gallstone disease by FXR agonists in a mouse model by Mangelsdorf, David J, Moschetta, Antonio, Bookout, Angie L

“…Cholesterol gallstone disease is characterized by several events, including cholesterol precipitation in bile, increased bile salt hydrophobicity and…”
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