Search Results - "Manganiello, Vincent c"

Targeted disruption of PDE3B, but not PDE3A, protects murine heart from ischemia/reperfusion injury by Chung, Youn Wook, Lagranh, Claudia, Chen, Yong, Sun, Junhui, Tong, Guang, Hockman, Steven C., Ahmad, Faiyaz, Esfahani, Shervin G., Bae, Dahae H., Polidovitch, Nazari, Wu, Jian, Rhee, Dong Keun, Lee, Beom Seob, Gucek, Marjan, Daniels, Mathew P., Brantner, Christine A., Backx, Peter H., Murphy, Elizabeth, Manganiello, Vincent C.

“…Although inhibition of cyclic nucleotide phosphodiesterase type 3 (PDE3) has been reported to protect rodent heart against ischemia/reperfusion (I/R) injury,…”
Get full text

Tumor Necrosis Factor-α Stimulates Lipolysis in Differentiated Human Adipocytes Through Activation of Extracellular Signal-Related Kinase and Elevation of Intracellular cAMP by ZHANG, Hui H, HALBLEIB, Melanie, AHMAD, Faiyaz, MANGANIELLO, Vincent C, GREENBERG, Andrew S

“…Tumor Necrosis Factor-α Stimulates Lipolysis in Differentiated Human Adipocytes Through Activation of Extracellular Signal-Related Kinase and Elevation of…”
Get full text

Expression and regulation of cyclic nucleotide phosphodiesterases in human and rat pancreatic islets by Heimann, Emilia, Jones, Helena A, Resjö, Svante, Manganiello, Vincent C, Stenson, Lena, Degerman, Eva

“…As shown by transgenic mouse models and by using phosphodiesterase 3 (PDE3) inhibitors, PDE3B has an important role in the regulation of insulin secretion in…”
Get full text

Alterations in regulation of energy homeostasis in cyclic nucleotide phosphodiesterase 3B-null mice by Choi, Young Hun, Park, Sunhee, Hockman, Steven, Zmuda-Trzebiatowska, Emilia, Svennelid, Fredrik, Haluzik, Martin, Gavrilova, Oksana, Ahmad, Faiyaz, Pepin, Laurent, Napolitano, Maria, Taira, Masato, Sundler, Frank, Stenson Holst, Lena, Degerman, Eva, Manganiello, Vincent C

“…Cyclic nucleotide phosphodiesterase 3B (PDE3B) has been suggested to be critical for mediating insulin/IGF-1 inhibition of cAMP signaling in adipocytes, liver,…”
Get full text

Insulin-induced formation of macromolecular complexes involved in activation of cyclic nucleotide phosphodiesterase 3B (PDE3B) and its interaction with PKB by Ahmad, Faiyaz, Lindh, Rebecka, Tang, Yan, Weston, Marie, Degerman, Eva, Manganiello, Vincent C

“…Fractionation of 3T3-L1 adipocyte membranes revealed that PDE3B (phosphodiesterase 3B) was associated with PM (plasma membrane) and ER (endoplasmic…”
Get full text

Advances in targeting cyclic nucleotide phosphodiesterases by Maurice, Donald H., Ke, Hengming, Ahmad, Faiyaz, Wang, Yousheng, Chung, Jay, Manganiello, Vincent C.

“…Key Points The nucleotides cAMP and cGMP both regulate myriad effects in virtually all animal cells. These actions are coordinated through protein kinase A…”
Get full text

SFPQ, a multifunctional nuclear protein, regulates the transcription of PDE3A by Rhee, Dong Keun, Hockman, Steven C, Choi, Sun-Kyung, Kim, Yong-Eun, Park, Chungoo, Manganiello, Vincent C, Kim, Kee Kwang

“…Phosphodiesterase 3A (PDE3A), a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (PDE) family, plays important roles in oocyte maturation and…”
Get full text

Selective regulation of cyclic nucleotide phosphodiesterase PDE3A isoforms by Vandeput, Fabrice, Szabo-Fresnais, Nicolas, Ahmad, Faiyaz, Kho, Changwon, Lee, Ahyoung, Krall, Judith, Dunlop, Allan, Hazel, Mark W., Wohlschlegel, James A., Hajjar, Roger J., Houslay, Miles D., Manganiello, Vincent C., Movsesian, Matthew A.

“…Inhibitors of cyclic nucleotide phosphodiesterase (PDE) PDE3A have inotropic actions in human myocardium, but their long-term use increases mortality in…”
Get full text

Structure, Localization, and Regulation of cGMP-inhibited Phosphodiesterase (PDE3) by Degerman, Eva, Belfrage, Per, Manganiello, Vincent C.

Get full text

Phosphodiesterase 3B is localized in caveolae and smooth ER in mouse hepatocytes and is important in the regulation of glucose and lipid metabolism by Berger, Karin, Lindh, Rebecka, Wierup, Nils, Zmuda-Trzebiatowska, Emilia, Lindqvist, Andreas, Manganiello, Vincent C, Degerman, Eva

“…Cyclic nucleotide phosphodiesterases (PDEs) are important regulators of signal transduction processes mediated by cAMP and cGMP. One PDE family member, PDE3B,…”
Get full text

Isoforms of Cyclic Nucleotide Phosphodiesterase PDE3 and Their Contribution to cAMP Hydrolytic Activity in Subcellular Fractions of Human Myocardium by Hambleton, Ryan, Krall, Judith, Tikishvili, Eliso, Honeggar, Matthew, Ahmad, Faiyaz, Manganiello, Vincent C., Movsesian, Matthew A.

“…Three isoforms of PDE3 (cGMP-inhibited) cyclic nucleotide phosphodiesterase regulate cAMP content in different intracellular compartments of cardiac myocytes…”
Get full text

Isoforms of Cyclic Nucleotide Phosphodiesterase PDE3A in Cardiac Myocytes by Wechsler, Jeremy, Choi, Young-Hun, Krall, Judith, Ahmad, Faiyaz, Manganiello, Vincent C., Movsesian, Matthew A.

“…PDE3A cyclic nucleotide phosphodiesterases regulate cAMP- and cGMP-mediated intracellular signaling in cardiac myocytes. We used antibodies to different…”
Get full text

Phosphodiesterase 3A (PDE3A) Deletion Suppresses Proliferation of Cultured Murine Vascular Smooth Muscle Cells (VSMCs) via Inhibition of Mitogen-activated Protein Kinase (MAPK) Signaling and Alterations in Critical Cell Cycle Regulatory Proteins by Begum, Najma, Hockman, Steven, Manganiello, Vincent C.

“…Cyclic nucleotide phosphodiesterase 3 (PDE3) is an important regulator of cyclic adenosine monophosphate (cAMP) signaling within the cardiovascular system. In…”
Get full text

Interaction of phosphodiesterase 3A with brefeldin A-inhibited guanine nucleotide-exchange proteins BIG1 and BIG2 and effect on ARF1 activity by Puxeddu, Ermanno, Uhart, Marina, Li, Chun-Chun, Ahmad, Faiyaz, Pacheco-Rodriguez, Gustavo, Manganiello, Vincent C, Moss, Joel, Vaughan, Martha

“…ADP-ribosylation factors (ARFs) have crucial roles in vesicular trafficking. Brefeldin A-inhibited guanine nucleotide-exchange proteins (BIG)1 and BIG2…”
Get full text

Foxp3-dependent programme of regulatory T-cell differentiation by Rasmussen, Jeffrey P, Rudensky, Alexander Y, Fontenot, Jason D, Gavin, Marc A, Vasta, Valeria, Beavo, Joseph A, Manganiello, Vincent C

“…Regulatory CD4+ T cells (Tr cells), the development of which is critically dependent on X-linked transcription factor Foxp3 (forkhead box P3), prevent…”
Get full text

Early and rapid development of insulin resistance, islet dysfunction and glucose intolerance after high-fat feeding in mice overexpressing phosphodiesterase 3B by Walz, Helena A, Härndahl, Linda, Wierup, Nils, Zmuda-Trzebiatowska, Emilia, Svennelid, Fredrik, Manganiello, Vincent C, Ploug, Thorkil, Sundler, Frank, Degerman, Eva, Ahrén, Bo, Holst, Lena Stenson

“…Inadequate islet adaptation to insulin resistance leads to glucose intolerance and type 2 diabetes. Here we investigate whether β-cell cAMP is crucial for…”
Get full text

Phosphodiesterase 3A: a new player in development of interstitial cells of Cajal and a prospective target in gastrointestinal stromal tumors (GIST) by Vandenberghe, Pierre, Hagué, Perrine, Hockman, Steven C, Manganiello, Vincent C, Demetter, Pieter, Erneux, Christophe, Vanderwinden, Jean-Marie

“…We previously identified phosphodiesterase 3A (PDE3A) as a marker for interstitial cells of Cajal (ICC) in adult mouse gut. However, PDE3A expression and…”
Get full text

Phosphodiesterase 3B (PDE3B) regulates NLRP3 inflammasome in adipose tissue by Ahmad, Faiyaz, Chung, Youn Wook, Tang, Yan, Hockman, Steven C., Liu, Shiwei, Khan, Yusuf, Huo, Kevin, Billings, Eric, Amar, Marcelo J., Remaley, Alan T., Manganiello, Vincent C.

“…Activation of inflammation in white adipose tissue (WAT), includes infiltration/expansion of WAT macrophages, contributes pathogenesis of obesity, insulin…”
Get full text

Importance of cAMP-response Element-binding Protein in Regulation of Expression of the Murine Cyclic Nucleotide Phosphodiesterase 3B (Pde3b) Gene in Differentiating 3T3-L1 Preadipocytes by Liu, Hanguan, Tang, Jing Rong, Choi, Young Hun, Napolitano, Maria, Hockman, Steven, Taira, Masato, Degerman, Eva, Manganiello, Vincent C.

“…Incubation of 3T3-L1 preadipocytes with isobutylmethylxanthine (IBMX), dexamethasone, and insulin, alone or in combination, demonstrated that IBMX, which…”
Get full text

Dual Effects of Pituitary Adenylate Cyclase-Activating Polypeptide and Isoproterenol on Lipid Metabolism and Signaling in Primary Rat Adipocytes by Åkesson, Lina, Ahrén, Bo, Manganiello, Vincent C, Holst, Lena Stenson, Edgren, Gudrun, Degerman, Eva

“…Pituitary adenylate cyclase-activating peptide (PACAP) is a neuropeptide that exerts its effects throughout the body by elevating the intracellular amounts of…”
Get full text