Search Results - "Manganiello, V. C."

Cyclic nucleotide phosphodiesterases (PDEs): diverse regulators of cyclic nucleotide signals and inviting molecular targets for novel therapeutic agents by Manganiello, V C, Degerman, E

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Cyclic nucleotide phosphodiesterase 3 signaling complexes by Ahmad, F, Degerman, E, Manganiello, V C

“…The superfamily of cyclic nucleotide phosphodiesterases is comprised of 11 gene families. By hydrolyzing cAMP and cGMP, PDEs are major determinants in the…”
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Molecular cloning of the rat adipocyte hormone-sensitive cyclic GMP-inhibited cyclic nucleotide phosphodiesterase by Taira, M., Hockman, S.C., Calvo, J.C., Belfrage, P., Manganiello, V.C.

“…Two distinct but related cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI PDE) cDNAs were cloned from rat adipose tissue cDNA libraries. The open…”
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Identification of a novel isoform of the cyclic-nucleotide phosphodiesterase PDE3A expressed in vascular smooth-muscle myocytes by Choi, Y H, Ekholm, D, Krall, J, Ahmad, F, Degerman, E, Manganiello, V C, Movsesian, M A

“…We have identified a new cyclic-nucleotide phosphodiesterase isoform, PDE3A, and cloned its cDNA from cultured aortic myocytes. The nucleotide sequence of its…”
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Distinctive anatomical patterns of gene expression for cGMP-inhibited cyclic nucleotide phosphodiesterases by Reinhardt, R R, Chin, E, Zhou, J, Taira, M, Murata, T, Manganiello, V C, Bondy, C A

“…Type III cGMP-inhibited phosphodiesterases (PDE3s) play important roles in hormonal regulation of lipolysis, platelet aggregation, myocardial contractility,…”
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Effects of atrial natriuretic factor on cyclic guanosine monophosphate and cyclic adenosine monophosphate accumulation in microdissected nephron segments from rats by NONOGUCHI, H, KNEPPER, M. A, MANGANIELLO, V. C

“…Atrial natriuretic factor (ANF) (1 microM) markedly increased cyclic guanosine monophosphate (cGMP) content in microdissected glomeruli (35-fold) and in…”
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Steroid-sparing effects of pentoxifylline in pulmonary sarcoidosis by Park, M K, Fontana, Jr, Babaali, H, Gilbert-McClain, L I, Stylianou, M, Joo, J, Moss, J, Manganiello, V C

“…Agents that target pro-inflammatory cytokines may be useful in pulmonary sarcoidosis. To determine effectiveness of a non-selective cyclic nucleotide…”
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Evidence that insulin and isoprenaline activate the cGMP-inhibited low-Km cAMP phosphodiesterase in rat fat cells by phosphorylation by DEGERMAN, E, SMITH, C. J, TORNQVIST, H, VASTA, V, BELFRAGE, P, MANGANIELLO, V. C

“…Incubation of intact rat fat cells with maximally effective concentrations of insulin (1 nM, 12 min) or isoprenaline (300 nM, 3 min) increased particulate…”
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cGMP-inhibited phosphodiesterases (PDE3 gene family) by Degerman, E, Belfrage, P, Manganiello, V C

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Phorbol 12-myristate 13-acetate and vasopressin potentiate the effect of corticotropin-releasing factor on cyclic AMP production in rat anterior pituitary cells. Mechanisms of action by Abou-Samra, A B, Harwood, J P, Manganiello, V C, Catt, K J, Aguilera, G

“…The potentiation of corticotropin-releasing factor (CRF)-stimulated cAMP production by vasopressin (VP) in the pituitary cell was investigated by studies on…”
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Hormone-sensitive cyclic GMP-inhibited cyclic AMP phosphodiesterase in rat adipocytes. Regulation of insulin- and cAMP-dependent activation by phosphorylation by SMITH, C. J, VASTA, V, DEGERMAN, E, BELFRAGE, P, MANGANIELLO, V. C

“…In 32PO4-labeled adipocytes, isoproterenol (ISO) or physiologically relevant concentrations of insulin rapidly increased phosphorylation of a particulate…”
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Structure, Localization, and Regulation of cGMP-inhibited Phosphodiesterase (PDE3) by Degerman, Eva, Belfrage, Per, Manganiello, Vincent C.

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Purification of the putative hormone-sensitive cyclic AMP phosphodiesterase from rat adipose tissue using a derivative of cilostamide as a novel affinity ligand by Degerman, E., Belfrage, P., Newman, A.H., Rice, K.C., Manganiello, V.C.

“…A “low Km” cAMP phosphodiesterase with properties of a peripheral membrane protein accounts for approximately 90% of total cAMP phosphodiesterase activity in…”
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Characterization of the cDNA and Gene Encoding Human PDE3B, the cGIP1 Isoform of the Human Cyclic GMP-Inhibited Cyclic Nucleotide Phosphodiesterase Family by Miki, Takashi, Taira, Masato, Hockman, Steven, Shimada, Fumio, Lieman, Jonathan, Napolitano, Maria, Ward, David, Taira, Masanori, Makino, Hideichi, Manganiello, Vincent C.

“…Two distinct PDE3 [cyclic GMP-inhibited cyclic nucleotide phosphodiesterase (cGI PDE)] isoforms, cGIP1 and cGIP2, have been identified. Here we report cloning…”
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Role of hormone-sensitive low Km cAMP phosphodiesterase in regulation of cAMP-dependent protein kinase and lipolysis in rat adipocytes by Smith, C J, Manganiello, V C

“…The time-courses of isoproterenol activation of rat adipocyte particulate low Km cAMP phosphodiesterase (PDE) activity, cAMP-dependent protein kinase…”
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Phosphodiesterase 3 as a potential target for therapy of malignant tumors in the submandibular gland by Murata, Taku, Sugatani, Toshifumi, Shimizu, Kasumi, Manganiello, Vincent C, Tagawa, Toshiro

“…Phosphodiesterase (PDE) 3s have been characterized in human neoplastic submandibular gland intercalated duct HSG cells. There have been no reports on PDE3 in…”
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Sarcoplasmic reticulum-associated cyclic adenosine 5'-monophosphate phosphodiesterase activity in normal and failing human hearts by Movsesian, M A, Smith, C J, Krall, J, Bristow, M R, Manganiello, V C

“…Sarcoplasmic reticulum-associated cAMP phosphodiesterase activity was examined in microsomes prepared from the left ventricular myocardium of eight heart…”
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Purification and characterization of cyclic GMP-stimulated cyclic nucleotide phosphodiesterase from calf liver. Effects of divalent cations on activity by Yamamoto, T, Manganiello, V C, Vaughan, M

“…Cyclic GMP-stimulated cyclic nucleotide phosphodiesterase purified greater than 13,000-fold to apparent homogeneity from calf liver exhibited a single protein…”
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Hormone-sensitive particulate cAMP phosphodiesterase activity in 3T3-L1 adipocytes. Regulation of responsiveness by dexamethasone by Elks, M L, Manganiello, V C, Vaughan, M

“…Confluent 3T3-L1 fibroblasts incubated for 72 h with methylisobutylxanthine, dexamethasone, and insulin differentiate and acquire phenotypic characteristics of…”
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Cytosolic and sarcoplasmic reticulum-associated low Km, cGMP-inhibited cAMP phosphodiesterase in mammalian myocardium by Smith, C J, Krall, J, Manganiello, V C, Movsesian, M A

“…The distribution and phosphoprotein band patterns of low Km, cGMP-inhibited cAMP phosphodiesterase (cGI PDE) activity were examined in cytosolic and microsomal…”
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