Search Results - "Manganiello, C."

Targeted disruption of PDE3B, but not PDE3A, protects murine heart from ischemia/reperfusion injury by Chung, Youn Wook, Lagranh, Claudia, Chen, Yong, Sun, Junhui, Tong, Guang, Hockman, Steven C., Ahmad, Faiyaz, Esfahani, Shervin G., Bae, Dahae H., Polidovitch, Nazari, Wu, Jian, Rhee, Dong Keun, Lee, Beom Seob, Gucek, Marjan, Daniels, Mathew P., Brantner, Christine A., Backx, Peter H., Murphy, Elizabeth, Manganiello, Vincent C.

“…Although inhibition of cyclic nucleotide phosphodiesterase type 3 (PDE3) has been reported to protect rodent heart against ischemia/reperfusion (I/R) injury,…”
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A multi-model assessment of the impact of currents, waves and wind in modelling surface drifters and oil spill by De Dominicis, M., Bruciaferri, D., Gerin, R., Pinardi, N., Poulain, P.M., Garreau, P., Zodiatis, G., Perivoliotis, L., Fazioli, L., Sorgente, R., Manganiello, C.

“…Validation of oil spill forecasting systems suffers from a lack of data due to the scarcity of oil slick in situ and satellite observations. Drifters (surface…”
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Tumor Necrosis Factor-α Stimulates Lipolysis in Differentiated Human Adipocytes Through Activation of Extracellular Signal-Related Kinase and Elevation of Intracellular cAMP by ZHANG, Hui H, HALBLEIB, Melanie, AHMAD, Faiyaz, MANGANIELLO, Vincent C, GREENBERG, Andrew S

“…Tumor Necrosis Factor-α Stimulates Lipolysis in Differentiated Human Adipocytes Through Activation of Extracellular Signal-Related Kinase and Elevation of…”
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Expression and regulation of cyclic nucleotide phosphodiesterases in human and rat pancreatic islets by Heimann, Emilia, Jones, Helena A, Resjö, Svante, Manganiello, Vincent C, Stenson, Lena, Degerman, Eva

“…As shown by transgenic mouse models and by using phosphodiesterase 3 (PDE3) inhibitors, PDE3B has an important role in the regulation of insulin secretion in…”
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Structure, Localization, and Regulation of cGMP-inhibited Phosphodiesterase (PDE3) by Degerman, Eva, Belfrage, Per, Manganiello, Vincent C.

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Alterations in regulation of energy homeostasis in cyclic nucleotide phosphodiesterase 3B-null mice by Choi, Young Hun, Park, Sunhee, Hockman, Steven, Zmuda-Trzebiatowska, Emilia, Svennelid, Fredrik, Haluzik, Martin, Gavrilova, Oksana, Ahmad, Faiyaz, Pepin, Laurent, Napolitano, Maria, Taira, Masato, Sundler, Frank, Stenson Holst, Lena, Degerman, Eva, Manganiello, Vincent C

“…Cyclic nucleotide phosphodiesterase 3B (PDE3B) has been suggested to be critical for mediating insulin/IGF-1 inhibition of cAMP signaling in adipocytes, liver,…”
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Isoforms of Cyclic Nucleotide Phosphodiesterase PDE3 and Their Contribution to cAMP Hydrolytic Activity in Subcellular Fractions of Human Myocardium by Hambleton, Ryan, Krall, Judith, Tikishvili, Eliso, Honeggar, Matthew, Ahmad, Faiyaz, Manganiello, Vincent C., Movsesian, Matthew A.

“…Three isoforms of PDE3 (cGMP-inhibited) cyclic nucleotide phosphodiesterase regulate cAMP content in different intracellular compartments of cardiac myocytes…”
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Selective regulation of cyclic nucleotide phosphodiesterase PDE3A isoforms by Vandeput, Fabrice, Szabo-Fresnais, Nicolas, Ahmad, Faiyaz, Kho, Changwon, Lee, Ahyoung, Krall, Judith, Dunlop, Allan, Hazel, Mark W., Wohlschlegel, James A., Hajjar, Roger J., Houslay, Miles D., Manganiello, Vincent C., Movsesian, Matthew A.

“…Inhibitors of cyclic nucleotide phosphodiesterase (PDE) PDE3A have inotropic actions in human myocardium, but their long-term use increases mortality in…”
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Phosphodiesterase 3B is localized in caveolae and smooth ER in mouse hepatocytes and is important in the regulation of glucose and lipid metabolism by Berger, Karin, Lindh, Rebecka, Wierup, Nils, Zmuda-Trzebiatowska, Emilia, Lindqvist, Andreas, Manganiello, Vincent C, Degerman, Eva

“…Cyclic nucleotide phosphodiesterases (PDEs) are important regulators of signal transduction processes mediated by cAMP and cGMP. One PDE family member, PDE3B,…”
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Insulin-induced formation of macromolecular complexes involved in activation of cyclic nucleotide phosphodiesterase 3B (PDE3B) and its interaction with PKB by Ahmad, Faiyaz, Lindh, Rebecka, Tang, Yan, Weston, Marie, Degerman, Eva, Manganiello, Vincent C

“…Fractionation of 3T3-L1 adipocyte membranes revealed that PDE3B (phosphodiesterase 3B) was associated with PM (plasma membrane) and ER (endoplasmic…”
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Advances in targeting cyclic nucleotide phosphodiesterases by Maurice, Donald H., Ke, Hengming, Ahmad, Faiyaz, Wang, Yousheng, Chung, Jay, Manganiello, Vincent C.

“…Key Points The nucleotides cAMP and cGMP both regulate myriad effects in virtually all animal cells. These actions are coordinated through protein kinase A…”
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SFPQ, a multifunctional nuclear protein, regulates the transcription of PDE3A by Rhee, Dong Keun, Hockman, Steven C, Choi, Sun-Kyung, Kim, Yong-Eun, Park, Chungoo, Manganiello, Vincent C, Kim, Kee Kwang

“…Phosphodiesterase 3A (PDE3A), a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (PDE) family, plays important roles in oocyte maturation and…”
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Isoforms of Cyclic Nucleotide Phosphodiesterase PDE3A in Cardiac Myocytes by Wechsler, Jeremy, Choi, Young-Hun, Krall, Judith, Ahmad, Faiyaz, Manganiello, Vincent C., Movsesian, Matthew A.

“…PDE3A cyclic nucleotide phosphodiesterases regulate cAMP- and cGMP-mediated intracellular signaling in cardiac myocytes. We used antibodies to different…”
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Steroid-sparing effects of pentoxifylline in pulmonary sarcoidosis by Park, M K, Fontana, Jr, Babaali, H, Gilbert-McClain, L I, Stylianou, M, Joo, J, Moss, J, Manganiello, V C

“…Agents that target pro-inflammatory cytokines may be useful in pulmonary sarcoidosis. To determine effectiveness of a non-selective cyclic nucleotide…”
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Interaction of phosphodiesterase 3A with brefeldin A-inhibited guanine nucleotide-exchange proteins BIG1 and BIG2 and effect on ARF1 activity by Puxeddu, Ermanno, Uhart, Marina, Li, Chun-Chun, Ahmad, Faiyaz, Pacheco-Rodriguez, Gustavo, Manganiello, Vincent C, Moss, Joel, Vaughan, Martha

“…ADP-ribosylation factors (ARFs) have crucial roles in vesicular trafficking. Brefeldin A-inhibited guanine nucleotide-exchange proteins (BIG)1 and BIG2…”
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Cyclic nucleotide phosphodiesterases (PDEs): diverse regulators of cyclic nucleotide signals and inviting molecular targets for novel therapeutic agents by Manganiello, V C, Degerman, E

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Phosphodiesterase 3A (PDE3A) Deletion Suppresses Proliferation of Cultured Murine Vascular Smooth Muscle Cells (VSMCs) via Inhibition of Mitogen-activated Protein Kinase (MAPK) Signaling and Alterations in Critical Cell Cycle Regulatory Proteins by Begum, Najma, Hockman, Steven, Manganiello, Vincent C.

“…Cyclic nucleotide phosphodiesterase 3 (PDE3) is an important regulator of cyclic adenosine monophosphate (cAMP) signaling within the cardiovascular system. In…”
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Foxp3-dependent programme of regulatory T-cell differentiation by Rasmussen, Jeffrey P, Rudensky, Alexander Y, Fontenot, Jason D, Gavin, Marc A, Vasta, Valeria, Beavo, Joseph A, Manganiello, Vincent C

“…Regulatory CD4+ T cells (Tr cells), the development of which is critically dependent on X-linked transcription factor Foxp3 (forkhead box P3), prevent…”
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β-Cell-targeted Overexpression of Phosphodiesterase 3B in Mice Causes Impaired Insulin Secretion, Glucose Intolerance, and Deranged Islet Morphology by Härndahl, Linda, Wierup, Nils, Enerbäck, Sven, Mulder, Hindrik, Manganiello, Vincent C., Sundler, Frank, Degerman, Eva, Ahrén, Bo, Holst, Lena Stenson

“…The second messenger cAMP mediates potentiation of glucose-stimulated insulin release. Use of inhibitors of cAMP-hydrolyzing phosphodiesterase (PDE) 3 and…”
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Functions of the N-terminal Region of Cyclic Nucleotide Phosphodiesterase 3 (PDE 3) Isoforms by Kenan, Yael, Murata, Taku, Shakur, Yasmin, Degerman, Eva, Manganiello, Vincent C.

“…The N-terminal portion of phosphodiesterase (PDE) 3 was arbitrarily divided into region 1 (amino acids 1–300), which contains a large hydrophobic domain with…”
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