Search Results - "Mangan, Matthew S. J."

Targeting the NLRP3 inflammasome in inflammatory diseases by Mangan, Matthew S. J., Olhava, Edward J., Roush, William R., Seidel, H. Martin, Glick, Gary D., Latz, Eicke

“…The inflammasome is a key integration point for innate immunity. As such, targeting this signalling hub has the potential to be useful in numerous autoimmune…”
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Transcriptional licensing is required for Pyrin inflammasome activation in human macrophages and bypassed by mutations causing familial Mediterranean fever by Mangan, Matthew S J, Gorki, Friederike, Krause, Karoline, Heinz, Alexander, Pankow, Anne, Ebert, Thomas, Jahn, Dieter, Hiller, Karsten, Hornung, Veit, Maurer, Marcus, Schmidt, Florian I, Gerhard, Ralf, Latz, Eicke

“…Pyrin is a cytosolic immune sensor that nucleates an inflammasome in response to inhibition of RhoA by bacterial virulence factors, triggering the release of…”
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How location and cellular signaling combine to activate the NLRP3 inflammasome by Akbal, Anil, Dernst, Alesja, Lovotti, Marta, Mangan, Matthew S. J., McManus, Róisín M., Latz, Eicke

“…NOD-, LRR-, and pyrin domain-containing 3 (NLRP3) is a cytosolic innate immune sensor of cellular stress signals, triggered by infection and sterile…”
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Toll-like Receptor Signaling Rewires Macrophage Metabolism and Promotes Histone Acetylation via ATP-Citrate Lyase by Lauterbach, Mario A., Hanke, Jasmin E., Serefidou, Magdalini, Mangan, Matthew S.J., Kolbe, Carl-Christian, Hess, Timo, Rothe, Maximilian, Kaiser, Romina, Hoss, Florian, Gehlen, Jan, Engels, Gudrun, Kreutzenbeck, Maike, Schmidt, Susanne V., Christ, Anette, Imhof, Axel, Hiller, Karsten, Latz, Eicke

“…Toll-like receptor (TLR) activation induces inflammatory responses in macrophages by activating temporally defined transcriptional cascades. Whether concurrent…”
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NLRC3 Puts the Brakes on STING by Mangan, Matthew S.J., Latz, Eicke

“…NOD-like receptors (NLRs) are increasingly implicated in regulating pathogen-sensing pathways. In this issue of Immunity, Zhang et al. (2014) describe a role…”
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Mitochondrial damage activates the NLRP10 inflammasome by Próchnicki, Tomasz, Vasconcelos, Matilde B., Robinson, Kim S., Mangan, Matthew S. J., De Graaf, Dennis, Shkarina, Kateryna, Lovotti, Marta, Standke, Lena, Kaiser, Romina, Stahl, Rainer, Duthie, Fraser G., Rothe, Maximilian, Antonova, Kateryna, Jenster, Lea-Marie, Lau, Zhi Heng, Rösing, Sarah, Mirza, Nora, Gottschild, Clarissa, Wachten, Dagmar, Günther, Claudia, Kufer, Thomas A., Schmidt, Florian I., Zhong, Franklin L., Latz, Eicke

“…Upon detecting pathogens or cell stress, several NOD-like receptors (NLRs) form inflammasome complexes with the adapter ASC and caspase-1, inducing gasdermin D…”
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Targeting the NLRP3 inflammasome in inflammatory diseases by Mangan, Matthew S J, Olhava, Edward J, Roush, William R, Seidel, H Martin, Glick, Gary D, Latz, Eicke

“…This corrects the article DOI: 10.1038/nrd.2018.97…”
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Spatiotemporal proteomics uncovers cathepsin-dependent macrophage cell death during Salmonella infection by Selkrig, Joel, Li, Nan, Hausmann, Annika, Mangan, Matthew S. J., Zietek, Matylda, Mateus, André, Bobonis, Jacob, Sueki, Anna, Imamura, Haruna, El Debs, Bachir, Sigismondo, Gianluca, Florea, Bogdan I., Overkleeft, Herman S., Kopitar-Jerala, Nataša, Turk, Boris, Beltrao, Pedro, Savitski, Mikhail M., Latz, Eicke, Hardt, Wolf-Dietrich, Krijgsveld, Jeroen, Typas, Athanasios

“…The interplay between host and pathogen relies heavily on rapid protein synthesis and accurate protein targeting to ensure pathogen destruction. To gain…”
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1-Deoxysphingolipids cause autophagosome and lysosome accumulation and trigger NLRP3 inflammasome activation by Lauterbach, Mario A., Saavedra, Victor, Mangan, Matthew S. J., Penno, Anke, Thiele, Christoph, Latz, Eicke, Kuerschner, Lars

“…1-Deoxysphingolipids (deoxySLs) are atypical sphingolipids of clinical relevance as they are elevated in plasma of patients suffering from hereditary sensory…”
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Serpinb9 (Spi6)‐deficient mice are impaired in dendritic cell‐mediated antigen cross‐presentation by Rizzitelli, Alexandra, Meuter, Simone, Vega Ramos, Javier, Bird, Catherina H, Mintern, Justine D, Mangan, Matthew SJ, Villadangos, Jose, Bird, Phillip I

“…Serpinb9 (Sb9, also called Spi6) is an intracellular inhibitor of granzyme B (GrB) that protects activated cytotoxic lymphocytes from apoptosis. We show here…”
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Cutting Edge: STING Induces ACLY Activation and Metabolic Adaptations in Human Macrophages through TBK1 by Nickenig, Maximilian, Mangan, Matthew S J, Lee, Hye Eun, Symeonidis, Konstantinos, Henne, Antonia, Kaiser, Romina, Geißmar, Eike, Garritsen, Hendrikus, Abdullah, Zeinab, Hiller, Karsten, Latz, Eicke, Lauterbach, Mario A

“…The 2'3'-cyclic GMP-AMP (cGAMP) synthase (cGAS)-stimulator of IFN genes (STING) pathway can sense infection and cellular stress by detecting cytosolic DNA…”
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Monitoring of Inflammasome Activation of Macrophages and Microglia In Vitro, Part 2: Assessing Inflammasome Activation by Lovotti, Marta, Mangan, Matthew S J, McManus, Róisín M, Shkarina, Kateryna, Vasconcelos, Matilde B, Latz, Eicke

“…Inflammasomes are macromolecular complexes that assemble upon the detection of cytoplasmic pathogen-associated or danger-associated signals and induce a…”
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Monitoring of Inflammasome Activation of Macrophages and Microglia In Vitro, Part 1: Cell Preparation and Inflammasome Stimulation by Lovotti, Marta, Mangan, Matthew S J, McManus, Róisín M, Shkarina, Kateryna, Vasconcelos, Matilde B, Latz, Eicke

“…Inflammasomes are intracellular, multiprotein supercomplexes that mediate a post-translational inflammatory response to both pathogen and endogenous danger…”
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Topical application of a CCL22-binding aptamer suppresses contact allergy by Jonczyk, Anna, Gottschalk, Marlene, Mangan, Matthew S.J., Majlesain, Yasmin, Thiem, Manja W., Burbaum, Lea-Corinna, Weighardt, Heike, Latz, Eicke, Mayer, Günter, Förster, Irmgard

“…Allergic contact dermatitis is a prevalent occupational disease with limited therapeutic options. The chemokine CCL22, a ligand of the chemokine receptor CCR4,…”
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Butyrate and propionate are microbial danger signals that activate the NLRP3 inflammasome in human macrophages upon TLR stimulation by Wang, Wei, Dernst, Alesja, Martin, Bianca, Lorenzi, Lucia, Cadefau-Fabregat, Maria, Phulphagar, Kshiti, Wagener, Antonia, Budden, Christina, Stair, Neil, Wagner, Theresa, Färber, Harald, Jaensch, Andreas, Stahl, Rainer, Duthie, Fraser, Schmidt, Susanne V., Coll, Rebecca C., Meissner, Felix, Cuartero, Sergi, Latz, Eicke, Mangan, Matthew S.J.

“…Short-chain fatty acids (SCFAs) are immunomodulatory compounds produced by the microbiome through dietary fiber fermentation. Although generally considered…”
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Erratum: Targeting the NLRP3 inflammasome in inflammatory diseases by Mangan, Matthew S. J., Olhava, Edward J., Roush, William R., Seidel, H. Martin, Glick, Gary D., Latz, Eicke

“…Nature Reviews Drug Discovery 17, 588–606 (2018) A sentence mentioning the authors of reference 122 has been amended to include both corresponding authors…”
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A Novel Serpin Regulatory Mechanism: SerpinB9 IS REVERSIBLY INHIBITED BY VICINAL DISULFIDE BOND FORMATION IN THE REACTIVE CENTER LOOP by Mangan, Matthew S J, Bird, Catherina H, Kaiserman, Dion, Matthews, Anthony Y, Hitchen, Corinne, Steer, David L, Thompson, Philip E, Bird, Phillip I

“…The intracellular protease inhibitor Sb9 (SerpinB9) is a regulator of the cytotoxic lymphocyte protease GzmB (granzyme B). Although GzmB is primarily involved…”
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Metabolic rewiring promotes anti-inflammatory effects of glucocorticoids by Auger, Jean-Philippe, Zimmermann, Max, Faas, Maria, Stifel, Ulrich, Chambers, David, Krishnacoumar, Brenda, Taudte, R. Verena, Grund, Charlotte, Erdmann, Gitta, Scholtysek, Carina, Uderhardt, Stefan, Ben Brahim, Oumaima, Pascual Maté, Mónica, Stoll, Cornelia, Böttcher, Martin, Palumbo-Zerr, Katrin, Mangan, Matthew S. J., Dzamukova, Maria, Kieler, Markus, Hofmann, Melanie, Blüml, Stephan, Schabbauer, Gernot, Mougiakakos, Dimitrios, Sonnewald, Uwe, Hartmann, Fabian, Simon, David, Kleyer, Arnd, Grüneboom, Anika, Finotto, Susetta, Latz, Eicke, Hofmann, Jörg, Schett, Georg, Tuckermann, Jan, Krönke, Gerhard

“…Glucocorticoids represent the mainstay of therapy for a broad spectrum of immune-mediated inflammatory diseases. However, the molecular mechanisms underlying…”
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Serpinb9 (Spi6)‐deficient mice are impaired in dendritic cell‐mediated antigen cross‐presentation by Rizzitelli, Alexandra, Meuter, Simone, Vega Ramos, Javier, Bird, Catherina H, Mintern, Justine D, Mangan, Matthew SJ, Villadangos, Jose, Bird, Phillip I

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