Search Results - "Mangan, Kile P."

An Epilepsy-Associated KCNT1 Mutation Enhances Excitability of Human iPSC-Derived Neurons by Increasing Slack KNa Currents by Quraishi, Imran H, Stern, Shani, Mangan, Kile P, Zhang, Yalan, Ali, Syed R, Mercier, Michael R, Marchetto, Maria C, McLachlan, Michael J, Jones, Eugenia M, Gage, Fred H, Kaczmarek, Leonard K

“…Mutations in the KCNT1 (Slack, KNa1.1) sodium-activated potassium channel produce severe epileptic encephalopathies. Expression in heterologous systems has…”
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Cortical Tonic Inhibition Gates the Expression of Spike-and-Wave Discharges Associated with Absence Epilepsy by Mangan, Kile P, Nelson, Aaron B, Petrou, Steven, Cirelli, Chiara, Jones, Mathew V

“…Absence seizures result from aberrant thalamocortical processing that confers synchronous, bilateral spike-and-wave discharges (SWDs) and behavioral arrest…”
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Cryopreservation Maintains Functionality of Human iPSC Dopamine Neurons and Rescues Parkinsonian Phenotypes In Vivo by Wakeman, Dustin R., Hiller, Benjamin M., Marmion, David J., McMahon, Christopher W., Corbett, Grant T., Mangan, Kile P., Ma, Junyi, Little, Lauren E., Xie, Zhong, Perez-Rosello, Tamara, Guzman, Jaime N., Surmeier, D. James, Kordower, Jeffrey H.

“…A major challenge for clinical application of pluripotent stem cell therapy for Parkinson's disease (PD) is large-scale manufacturing and cryopreservation of…”
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Reduced synaptic activity and dysregulated extracellular matrix pathways in midbrain neurons from Parkinson’s disease patients by Stern, Shani, Lau, Shong, Manole, Andreea, Rosh, Idan, Percia, Menachem Mendel, Ben Ezer, Ran, Shokhirev, Maxim N., Qiu, Fan, Schafer, Simon, Mansour, Abed AlFatah, Mangan, Kile P., Stern, Tchelet, Ofer, Polina, Stern, Yam, Diniz Mendes, Ana Paula, Djamus, Jose, Moore, Lynne Randolph, Nayak, Ritu, Laufer, Sapir Havusha, Aicher, Aidan, Rhee, Amanda, Wong, Thomas L., Nguyen, Thao, Linker, Sara B., Winner, Beate, Freitas, Beatriz C., Jones, Eugenia, Sagi, Irit, Bardy, Cedric, Brice, Alexis, Winkler, Juergen, Marchetto, Maria C., Gage, Fred H.

“…Several mutations that cause Parkinson’s disease (PD) have been identified over the past decade. These account for 15–25% of PD cases; the rest of the cases…”
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NMDA and dopamine converge on the NMDA-receptor to induce ERK activation and synaptic depression in mature hippocampus by Kaphzan, Hanoch, O'Riordan, Kenneth J, Mangan, Kile P, Levenson, Jonathan M, Rosenblum, Kobi

“…The formation of enduring internal representation of sensory information demands, in many cases, convergence in time and space of two different stimuli. The…”
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An Epilepsy-Associated KCNT1 Mutation Enhances Excitability of Human iPSC-Derived Neurons by Increasing Slack K Na Currents by Quraishi, Imran H, Stern, Shani, Mangan, Kile P, Zhang, Yalan, Ali, Syed R, Mercier, Michael R, Marchetto, Maria C, McLachlan, Michael J, Jones, Eugenia M, Gage, Fred H, Kaczmarek, Leonard K

“…Mutations in the KCNT1 (Slack, K 1.1) sodium-activated potassium channel produce severe epileptic encephalopathies. Expression in heterologous systems has…”
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Turning Back the Clock on Neurodegeneration by Mangan, Kile P., Levenson, Jonathan M.

“…Does neuronal loss associated with dementia necessarily impair the ability to learn new information and recall old memories? In a recent report in Nature,…”
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iPSC-Derived Neurons Harboring a Known Epilepsy Mutation Provide a ‘Disease-in-a-Dish’ Capability that Displays Established and Novel Epileptic Phenotypes by Mangan, Kile P., Quraishi, Imran, Zhang, Yalan, McLachlan, Michael, Meline, Benjamin, McMahon, Chris, Enghofer, Elisabeth, Kannemeier, Christian, Jones, Eugenia, Kaczmarek, Leonard

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Multiparametric assessment of networked electrical activity using induced pluripotent stem cell-derived glutamatergic neurons by Kim, Kwi Hye, Carlson, Coby, Kannemeier, Christian, Feaster, T.K., Swanson, Brad, Schlesinger, David, Anson, Blake D., Mangan, Kile P.

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IPSC-Derived Neurons Harboring a Known Epilepsy Mutation Display Known and Novel Electrophysiological Phenotypes by Carlson, Coby, Quaraishi, Imran, Zhang, Yalan, McLachlan, Michael, Meline, Benjamin, McMahon, Chris, Burke, Tom, Jones, Eugenia, Kaczmarek, Leonard, Mangan, Kile P.

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Modeling Neurological Disease with Human iPS Cell-Derived Neurons Containing a KCNT1 Mutation by Mangan, Kile P., McLachlan, Michael, Burke, Tom, Meline, Benjamin, Meyer, Nathan, Chase, Lucas, Swanson, Brad, Carlson, Coby B., DeLaura, Susan, Jones, Eugenia

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Prenatal cocaine exposure reduces glial cell line-derived neurotrophic factor (GDNF) in the striatum and the carotid body of the rat: implications for DA neurodevelopment by Lipton, Jack W, Ling, Zaodung, Vu, Toan Q, Robie, Heather C, Mangan, Kile P, Weese-Mayer, Debra E, Carvey, Paul M

“…Glial cell line-derived neurotrophic factor (GDNF) is a glycosylated, disulfide-bonded homodimer, and a member of the transforming growth factor-beta…”
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NMDA and Dopamine Converge on the NMDA-Receptor to Induce ERK Activation and Synaptic Depression in Mature Hippocampus by Kaphzan, Hanoch, O'Riordan, Kenneth J, Mangan, Kile P, Levenson, Jonathan M, Rosenblum, Kobi

“…The formation of enduring internal representation of sensory information demands, in many cases, convergence in time and space of two different stimuli. The…”
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Acute Cocaine Toxicity: Pharmacology and Clinical Presentations in Adult and Pediatric Populations by Lipton, Jack W., Mangan, Kile P., Silvestri, Jean M.

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Acute Cocaine Toxicity: Pharmacology and Clinical Presentations in Adult and Pediatric Populations by Lipton, Jack W., Mangan, Kile P., Silvestri, Jean M.

“…Cocaine remains the most prevalent drug responsible for emergency department (ED) visits. A majority of acute cocaine toxicity cases involve young, habitual,…”
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