Search Results - "Mangalmurti, Nilam S"

The Evolving Erythrocyte: Red Blood Cells as Modulators of Innate Immunity by Anderson, H Luke, Brodsky, Igor E, Mangalmurti, Nilam S

“…The field of red cell biology is undergoing a quiet revolution. Long assumed to be inert oxygen carriers, RBCs are emerging as important modulators of the…”
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DNA binding to TLR9 expressed by red blood cells promotes innate immune activation and anemia by Lam, L K Metthew, Murphy, Sophia, Kokkinaki, Dimitra, Venosa, Alessandro, Sherrill-Mix, Scott, Casu, Carla, Rivella, Stefano, Weiner, Aaron, Park, Jeongho, Shin, Sunny, Vaughan, Andrew E, Hahn, Beatrice H, Odom John, Audrey R, Meyer, Nuala J, Hunter, Christopher A, Worthen, G Scott, Mangalmurti, Nilam S

“…Red blood cells (RBCs) are essential for aerobic respiration through delivery of oxygen to distant tissues. However, RBCs are currently considered…”
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Red blood cells induce necroptosis of lung endothelial cells and increase susceptibility to lung inflammation by Qing, Danielle Y, Conegliano, David, Shashaty, Michael G S, Seo, Jeongyun, Reilly, John P, Worthen, G Scott, Huh, Dongeun, Meyer, Nuala J, Mangalmurti, Nilam S

“…Red blood cell (RBC) transfusions are associated with increased risk of acute respiratory distress syndrome (ARDS) in the critically ill, yet the mechanisms…”
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Human red blood cells express the RNA sensor TLR7 by Metthew Lam, L. K., Oatman, Emily, Eckart, Kaitlyn A., Klingensmith, Nathan J., Flowers, Emily, Sayegh, Layal, Yuen, Julia, Clements, Rebecca L., Meyer, Nuala J., Jurado, Kellie A., Vaughan, Andrew E., Eisenbarth, Stephanie C., Mangalmurti, Nilam S.

“…Red blood cells (RBCs) express the nucleic acid-binding toll-like receptor 9 (TLR9) and bind CpG-containing DNA. However, whether human RBCs express other…”
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The ABO histo-blood group, endothelial activation, and acute respiratory distress syndrome risk in critical illness by Reilly, John P, Meyer, Nuala J, Shashaty, Michael Gs, Anderson, Brian J, Ittner, Caroline, Dunn, Thomas G, Lim, Brian, Forker, Caitlin, Bonk, Michael P, Kotloff, Ethan, Feng, Rui, Cantu, Edward, Mangalmurti, Nilam S, Calfee, Carolyn S, Matthay, Michael A, Mikacenic, Carmen, Walley, Keith R, Russell, James, Christiani, David C, Wurfel, Mark M, Lanken, Paul N, Reilly, Muredach P, Christie, Jason D

“…BACKGROUNDThe ABO histo-blood group is defined by carbohydrate modifications and is associated with risk for multiple diseases, including acute respiratory…”
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Plasma receptor interacting protein kinase-3 levels are associated with acute respiratory distress syndrome in sepsis and trauma: a cohort study by Shashaty, Michael G S, Reilly, John P, Faust, Hilary E, Forker, Caitlin M, Ittner, Caroline A G, Zhang, Peggy X, Hotz, Meghan J, Fitzgerald, David, Yang, Wei, Anderson, Brian J, Holena, Daniel N, Lanken, Paul N, Christie, Jason D, Meyer, Nuala J, Mangalmurti, Nilam S

“…Necroptosis, a form of programmed cell death mediated by receptor interacting serine/threonine-protein kinase-3 (RIPK3), is implicated in murine models of…”
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A microengineered model of RBC transfusion-induced pulmonary vascular injury by Seo, Jeongyun, Conegliano, David, Farrell, Megan, Cho, Minseon, Ding, Xueting, Seykora, Thomas, Qing, Danielle, Mangalmurti, Nilam S., Huh, Dongeun

“…Red blood cell (RBC) transfusion poses significant risks to critically ill patients by increasing their susceptibility to acute respiratory distress syndrome…”
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Loss of red cell chemokine scavenging promotes transfusion-related lung inflammation by Mangalmurti, Nilam S., Xiong, Zeyu, Hulver, Mei, Ranganathan, Mrunalini, Liu, Xiang Hong, Oriss, Timothy, Fitzpatrick, Meghan, Rubin, Marc, Triulzi, Darrell, Choi, Augustine, Lee, Janet S.

“…Red cell transfusions are associated with the development of acute lung injury in the critically ill. Recent evidence suggests that storage induced alterations…”
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Collateral damage: necroptosis in the development of lung injury by Faust, Hilary, Mangalmurti, Nilam S

“…Cell death is increasingly recognized as a driving factor in the development of acute lung injury. Necroptosis, an immunogenic regulated cell death program…”
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The ultimate tradeoff: how red cell adaptations to malaria alter the host response during critical illness by Dobkin, Jane, Wu, Ling, Mangalmurti, Nilam S

“…The human immune system evolved in response to pathogens. Among these pathogens, malaria has proven to be one of the deadliest and has exerted the most potent…”
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Immunomodulatory roles of red blood cells by Dobkin, Jane, Mangalmurti, Nilam S.

“…Purpose of the Review To discuss recent advances supporting the role of red blood cells (RBCs) in the host immune response Recent Findings Over the last…”
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The receptor for advanced glycation end products mediates lung endothelial activation by RBCs by Mangalmurti, Nilam S, Friedman, Jessica L, Wang, Liang-Chuan, Stolz, Donna, Muthukumaran, Geetha, Siegel, Don L, Schmidt, Ann Marie, Lee, Janet S, Albelda, Steven M

“…The receptor for advanced glycation end products (RAGE) is a multiligand pattern recognition receptor implicated in multiple disease states. Although RAGE is…”
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Early Plasma Nuclear DNA, Mitochondrial DNA, and Nucleosome Concentrations Are Associated With Acute Kidney Injury in Critically Ill Trauma Patients by Faust, Hilary E, Oniyide, Oluwatosin, Wang, Yiyue, Forker, Caitlin M, Dunn, Thomas, Yang, Wei, Lanken, Paul N, Sims, Carrie A, Yehya, Nadir, Christie, Jason D, Meyer, Nuala J, Reilly, John P, Mangalmurti, Nilam S, Shashaty, Michael G S

“…Circulating nucleic acids, alone and in complex with histones as nucleosomes, have been proposed to link systemic inflammation and coagulation after trauma to…”
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Duffy antigen receptor for chemokines mediates chemokine endocytosis through a macropinocytosis-like process in endothelial cells by Zhao, Yani, Mangalmurti, Nilam S, Xiong, Zeyu, Prakash, Bharat, Guo, Fengli, Stolz, Donna B, Lee, Janet S

“…The Duffy antigen receptor for chemokines (DARC) shows high affinity binding to multiple inflammatory CC and CXC chemokines and is expressed by erythrocytes…”
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Red Blood Cells Homeostatically Bind Mitochondrial DNA through TLR9 to Maintain Quiescence and to Prevent Lung Injury by Hotz, Meghan J, Qing, Danielle, Shashaty, Michael G S, Zhang, Peggy, Faust, Hilary, Sondheimer, Neal, Rivella, Stefano, Worthen, G Scott, Mangalmurti, Nilam S

“…Potentially hazardous CpG-containing cell-free mitochondrial DNA (cf-mtDNA) is routinely released into the circulation and is associated with morbidity and…”
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Pharmacologic activation of the innate immune system to prevent respiratory viral infections by Cheng, Guanjun, Wang, Liang-Chuan S, Fridlender, Zvi G, Cheng, Guang-Shing, Chen, Bei, Mangalmurti, Nilam S, Saloura, Vassiliki, Yu, Zaifang, Kapoor, Veena, Mozdzanowska, Krystyna, Moon, Edmund, Sun, Jing, Kreindler, James L, Cohen, Noam A, Caton, Andrew J, Erikson, Jan, Albelda, Steven M

“…Drugs that can rapidly inhibit respiratory infection from influenza or other respiratory pathogens are needed. One approach is to engage primary innate immune…”
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Comprehensive mapping of immune perturbations associated with severe COVID-19 by Kuri-Cervantes, Leticia, Pampena, M Betina, Meng, Wenzhao, Rosenfeld, Aaron M, Ittner, Caroline A G, Weisman, Ariel R, Agyekum, Roseline S, Mathew, Divij, Baxter, Amy E, Vella, Laura A, Kuthuru, Oliva, Apostolidis, Sokratis A, Bershaw, Luanne, Dougherty, Jeanette, Greenplate, Allison R, Pattekar, Ajinkya, Kim, Justin, Han, Nicholas, Gouma, Sigrid, Weirick, Madison E, Arevalo, Claudia P, Bolton, Marcus J, Goodwin, Eileen C, Anderson, Elizabeth M, Hensley, Scott E, Jones, Tiffanie K, Mangalmurti, Nilam S, Luning Prak, Eline T, Wherry, E John, Meyer, Nuala J, Betts, Michael R

“…Although critical illness has been associated with SARS-CoV-2-induced hyperinflammation, the immune correlates of severe COVID-19 remain unclear. Here, we…”
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COVID-19-associated Acute Respiratory Distress Syndrome Clarified: A Vascular Endotype? by Mangalmurti, Nilam S, Reilly, John P, Cines, Douglas B, Meyer, Nuala J, Hunter, Christopher A, Vaughan, Andrew E

“…Mangalmurti et al discuss their study on COVID-19-associated respiratory distress syndrome. (COVID-19), the pandemic caused by severe acute respiratory…”
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ExRNA Takes a Toll in Sepsis-associated Lung Injury by Lam, L.K. Metthew, Mangalmurti, Nilam S.

“…Lam and Mangalmurti discuss the role of ExRNA in sepsis-associated lung injury. Extracellular RNA (exRNA) is primarily composed of microRNA (miRNA) and…”
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Plasma Mitochondrial DNA Levels Are Associated With ARDS in Trauma and Sepsis Patients by Faust, Hilary E., Reilly, John P., Anderson, Brian J., Ittner, Caroline A.G., Forker, Caitlyn M., Zhang, Peggy, Weaver, Benjamin A., Holena, Daniel N., Lanken, Paul N., Christie, Jason D., Meyer, Nuala J., Mangalmurti, Nilam S., Shashaty, Michael G.S.

“…Critically ill patients who develop ARDS have substantial associated morbidity and mortality. Circulating mitochondrial DNA (mtDNA) released during critical…”
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