Search Results - "Mang, Henry E"

Acute and chronic microvascular alterations in a mouse model of ischemic acute kidney injury by Hörbelt, Markus, Lee, So-Young, Mang, Henry E, Knipe, Nicole L, Sado, Yoshikazu, Kribben, Andreas, Sutton, Timothy A

“…Functional and structural abnormalities in the renal microvasculature are important processes contributing to the pathophysiology of ischemic acute kidney…”
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Endothelial STAT3 Modulates Protective Mechanisms in a Mouse Ischemia-Reperfusion Model of Acute Kidney Injury by Sutton, Timothy A., Dagher, Pierre C., Mang, Henry E., Yen, Jessica, Matam, Tejasvi, Dube, Shataakshi, Hato, Takashi

“…STAT3 is a transcriptional regulator that plays an important role in coordinating inflammation and immunity. In addition, there is a growing appreciation of…”
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Muc1 is protective during kidney ischemia-reperfusion injury by Pastor-Soler, Núria M, Sutton, Timothy A, Mang, Henry E, Kinlough, Carol L, Gendler, Sandra J, Madsen, Cathy S, Bastacky, Sheldon I, Ho, Jacqueline, Al-Bataineh, Mohammad M, Hallows, Kenneth R, Singh, Sucha, Monga, Satdarshan P, Kobayashi, Hanako, Haase, Volker H, Hughey, Rebecca P

“…Ischemia-reperfusion injury (IRI) due to hypotension is a common cause of human acute kidney injury (AKI). Hypoxia-inducible transcription factors (HIFs)…”
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MMP-9 gene deletion mitigates microvascular loss in a model of ischemic acute kidney injury by Lee, So-Young, Hörbelt, Markus, Mang, Henry E, Knipe, Nicole L, Bacallao, Robert L, Sado, Yoshikazu, Sutton, Timothy A

“…Microvascular rarefaction following an episode of acute kidney injury (AKI) is associated with renal hypoxia and progression toward chronic kidney disease. The…”
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Injury of the renal microvascular endothelium alters barrier function after ischemia by Sutton, Timothy A, Mang, Henry E, Campos, Silvia B, Sandoval, Ruben M, Yoder, Mervin C, Molitoris, Bruce A

“…The role of renal microvascular endothelial cell injury in the pathophysiology of ischemic acute renal failure (ARF) remains largely unknown. No consistent…”
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Inhibition of Toll-Like Receptor 4 Signaling Mitigates Microvascular Loss but Not Fibrosis in a Model of Ischemic Acute Kidney Injury by Dagher, Pierre C, Hato, Takashi, Mang, Henry E, Plotkin, Zoya, Richardson, Quentin V, Massad, Michael, Mai, Erik, Kuehl, Sarah E, Graham, Paige, Kumar, Rakesh, Sutton, Timothy A

“…The development of chronic kidney disease (CKD) following an episode of acute kidney injury (AKI) is an increasingly recognized clinical problem. Inhibition of…”
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Minocycline reduces renal microvascular leakage in a rat model of ischemic renal injury by Sutton, Timothy A, Kelly, K J, Mang, Henry E, Plotkin, Zoya, Sandoval, Ruben M, Dagher, Pierre C

“…Tetracyclines exhibit significant anti-inflammatory properties, inhibit matrix metalloproteinases (MMPs), and are protective in models of ischemia-reperfusion…”
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Mitochondrial depolarization and repolarization in the early stages of acetaminophen hepatotoxicity in mice by Dunn, Kenneth W., Martinez, Michelle M., Wang, Zemin, Mang, Henry E., Clendenon, Sherry G., Sluka, James P., Glazier, James A., Klaunig, James E.

“…Mitochondrial injury and depolarization are primary events in acetaminophen hepatotoxicity. Previous studies have shown that restoration of mitochondrial…”
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Muc1 enhances the β-catenin protective pathway during ischemia-reperfusion injury by Al-Bataineh, Mohammad M, Kinlough, Carol L, Poland, Paul A, Pastor-Soler, Núria M, Sutton, Timothy A, Mang, Henry E, Bastacky, Sheldon I, Gendler, Sandra J, Madsen, Cathy S, Singh, Sucha, Monga, Satdarshan P, Hughey, Rebecca P

“…The hypoxia-inducible factor (HIF)-1 and β-catenin protective pathways represent the two most significant cellular responses that are activated in response to…”
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The p53 inhibitor pifithrin-α can stimulate fibrosis in a rat model of ischemic acute kidney injury by Dagher, Pierre C, Mai, Erik M, Hato, Takashi, Lee, So-Young, Anderson, Melissa D, Karozos, Stephanie C, Mang, Henry E, Knipe, Nicole L, Plotkin, Zoya, Sutton, Timothy A

“…Inhibition of the tumor suppressor p53 diminishes tubular cell apoptosis and protects renal function in animal models of acute kidney injury (AKI). Therefore,…”
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Rho-kinase regulates myosin II activation in MDCK cells during recovery after ATP depletion by Sutton, T A, Mang, H E, Atkinson, S J

“…Alterations in the actin cytoskeleton of renal tubular epithelial cells during periods of ischemic injury and recovery have important consequences for normal…”
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Muc1 Modulates the Beta‐Catenin Protective Pathway During Ischemia‐Reperfusion Injury by Al‐bataineh, Mohammad M, Kinlough, Carol L, Pastor‐Soler, Nuria M, Sutton, Timothy A, Poland, Paul A, Mang, Henry E, Gendler, Sandra J, Madsen, Cathy S, Singh, Sucha, Bastacky, Sheldon I, Monga, Satdarshan P, Hughey, Rebecca P

“…Abstract only The HIF‐1 and β‐catenin protective pathways represent the two most significant cellular responses that are activated in response to acute kidney…”
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p53 regulates renal expression of HIF-1{alpha} and pVHL under physiological conditions and after ischemia-reperfusion injury by Sutton, Timothy A, Wilkinson, Jared, Mang, Henry E, Knipe, Nicole L, Plotkin, Zoya, Hosein, Maya, Zak, Katelyn, Wittenborn, Jeremy, Dagher, Pierre C

“…Ischemia-reperfusion injury (IRI) is a common cause of acute kidney injury (AKI) and is characterized by widespread tubular and microvascular damage. The tumor…”
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