Search Results - "Manfredi, James"

The Mdm2-p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor by Manfredi, James J

“…Mdm2 has been well characterized as a negative regulator of the tumor suppressor p53. Recent studies have shown that Mdm2 is activated in response to a variety…”
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Mdm2 and MdmX: Partners in p53 Destruction by Manfredi, James J

“…Mdm2 and MdmX are two closely related proteins that have been well-characterized as negative regulators of the tumor suppressor p53. Their interplay and…”
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Inactivation of Wild-Type p53 by Asparagine Endopeptidase in Glioblastoma: An Opportunity to Target the “Undruggable” by Manfredi, James J

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p53 and Development: Shedding Light on an Evolutionary Enigma by Manfredi, James J.

“…In this issue of Developmental Cell, Bowen et al. (2019) show that targeting p53 hyperactivity to distinct compartments in vivo results in diverse and…”
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p53 defies convention again: a p53 mutant that has lost tumor suppression but still can kill by Manfredi, James J

“…Loss of tumor suppression by the p53 protein involves altered or abrogated transcriptional activity resulting in a failure to mediate wild‐type cellular…”
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Another fork in the road-life or death decisions by the tumour suppressor p53 by Carvajal, Luis A, Manfredi, James J

“…In response to cellular stress signals, the tumour suppressor p53 accumulates and triggers a host of antineoplastic responses. For instance, DNA damage…”
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Robust p53 Stabilization Is Dispensable for Its Activation and Tumor Suppressor Function by Kon, Ning, Churchill, Michael, Li, Huan, Mukherjee, Siddhartha, Manfredi, James J, Gu, Wei

“…p53 is a short-lived protein with low basal levels under normal homeostasis conditions. However, upon DNA damage, levels of p53 dramatically increase for its…”
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Tumor suppression by p53 involves inhibiting an enabler, FGF13 by Manfredi, James J.

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Knockdown of Target Genes by siRNA In Vitro by Back, Songhee, Manfredi, James J

“…RNA interference (RNAi) is a cellular process involved in the silencing of genes, which makes RNAi important for observing and understanding the function of…”
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p53-independent effects of Mdm2 by Bohlman, Stephen, Manfredi, James J

“…Mdm2 is best known as the primary negative regulator of p53, but a growing body of evidence suggests that Mdm2 also has a number of functions independent of…”
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The p53 tumor suppressor participates in multiple cell cycle checkpoints by Giono, Luciana E., Manfredi, James J.

“…The process of cell division is highly ordered and regulated. Checkpoints exist to delay progression into the next cell cycle phase only when the previous step…”
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p53/HMGB1 Complexes Regulate Autophagy and Apoptosis by LIVESEY, Kristen M, RUI KANG, LOTZE, Michael T, DAOLIN TANG, VERNON, Philip, BUCHSER, William, LOUGHRAN, Patricia, WATKINS, Simon C, LIN ZHANG, MANFREDI, James J, ZEH, Herbert J, LUYUAN LI

“…The balance between apoptosis ("programmed cell death") and autophagy ("programmed cell survival") is important in tumor development and response to therapy…”
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In vivo RNA-seq and ChIP-seq analyses show an obligatory role for the C terminus of p53 in conferring tissue-specific radiation sensitivity by Resnick-Silverman, Lois, Zhou, Royce, Campbell, Moray J., Leibling, Ian, Parsons, Ramon, Manfredi, James J.

“…Thymus and spleen, in contrast to liver, are radiosensitive tissues in which p53-dependent apoptosis is triggered after whole-body radiation in vivo. Combined…”
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E2F7, a novel target, is up-regulated by p53 and mediates DNA damage-dependent transcriptional repression by Carvajal, Luis A, Hamard, Pierre-Jacques, Tonnessen, Crystal, Manfredi, James J

“…The p53 tumor suppressor protein is a transcription factor that exerts its effects on the cell cycle via regulation of gene expression. Although the mechanism…”
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The TP53 Database: transition from the International Agency for Research on Cancer to the US National Cancer Institute by de Andrade, Kelvin César, Lee, Elaine E., Tookmanian, Elise M., Kesserwan, Chimene A., Manfredi, James J., Hatton, Jessica N., Loukissas, Jennifer K., Zavadil, Jiri, Zhou, Lei, Olivier, Magali, Frone, Megan N., Shahzada, Owais, Longabaugh, William J. R., Kratz, Christian P., Malkin, David, Hainaut, Pierre, Savage, Sharon A.

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Mdm2-RNA Interactions as a Target for Cancer Therapy: It’s Not All About p53 by Bohlman, Stephen, Manfredi, James J.

“…In this issue of Cancer Cell, Gu et al. characterize small molecules that inhibit the interaction of Mdm2 with the mRNA that encodes the anti-apoptotic XIAP,…”
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Distinct mechanisms control genome recognition by p53 at its target genes linked to different cell fates by Farkas, Marina, Hashimoto, Hideharu, Bi, Yingtao, Davuluri, Ramana V., Resnick-Silverman, Lois, Manfredi, James J., Debler, Erik W., McMahon, Steven B.

“…The tumor suppressor p53 integrates stress response pathways by selectively engaging one of several potential transcriptomes, thereby triggering cell fate…”
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USP7 Enforces Heterochromatinization of p53 Target Promoters by Protecting SUV39H1 from MDM2-Mediated Degradation by Mungamuri, Sathish Kumar, Qiao, Rui F., Yao, Shen, Manfredi, James J., Gu, Wei, Aaronson, Stuart A.

“…The H3K9me3 repressive histone conformation of p53 target promoters is abrogated in response to p53 activation by MDM2-mediated SUV39H1 degradation. Here, we…”
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p53 Frameshift Mutations Couple Loss-of-Function with Unique Neomorphic Activities by Tong, David R, Zhou, Wen, Katz, Chen, Regunath, Kausik, Venkatesh, Divya, Ihuegbu, Chinyere, Manfredi, James J, Laptenko, Oleg, Prives, Carol

“…p53 mutations that result in loss of transcriptional activity are commonly found in numerous types of cancer. While the majority of these are missense…”
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The p53 C Terminus Controls Site-Specific DNA Binding and Promotes Structural Changes within the Central DNA Binding Domain by Laptenko, Oleg, Shiff, Idit, Freed-Pastor, Will, Zupnick, Andrew, Mattia, Melissa, Freulich, Ella, Shamir, Inbal, Kadouri, Noam, Kahan, Tamar, Manfredi, James, Simon, Itamar, Prives, Carol

“…DNA binding by numerous transcription factors including the p53 tumor suppressor protein constitutes a vital early step in transcriptional activation. While…”
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